Abstract P218: Role of UCP2 on Mitochondrial Dysfunction and Blood Pressure Regulation in the Renal Oxidative Stress-mediated Hypertension Associated With Dj-1 Depletion [Session Title: Onsite Poster Competition I With Reception]

In conclusion, deletion of DJ-1 leads to oxidative stress-induced hypertension associated with down-regulation of NO synthesis. UCP2 has protective properties against the development of MT dysfunction in MT oxidative stress conditions. However, excessive and chronic over expression of UCP2 could have deleterious consequences on BP regulation.
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research