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Total 445 results found since Jan 2013.

Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3
In conclusion, CAR suppressed lipid accumulation, mitochondrial dysfunction and hepatocyte apoptosis by activating PRDX3, mitigating the progression of NAFLD, and thus, CAR may represent a promising candidate for clinical treatment of steatosis.PMID:34678374 | DOI:10.1016/j.taap.2021.115758
Source: Toxicology and Applied Pharmacology - October 22, 2021 Category: Toxicology Authors: Yunfei Geng Yue Wang Ruimin Sun Xiaohui Kang Huanyu Zhao Meiyang Zhu Yu Sun Yan Hu Zhecheng Wang Xiaofeng Tian Yan Zhao Jihong Yao Source Type: research

MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice
Biomaterials. 2021 Oct 11;278:121183. doi: 10.1016/j.biomaterials.2021.121183. Online ahead of print.ABSTRACTThe changes of small intestinal homeostasis have been recognized to contribute essentially to the obese development. However, the core small intestinal regulator which mediates over-nutrient impacts on the homeostasis of the small intestines remains elusive. Here, we identify the MMP-12 as such a responsive factor in mouse small intestines. Taking advantages of the nano delivery system, we demonstrate that small intestine-specific MMP-12 knockdown alleviates high-fat diet feeding-induced metabolic disorders and impr...
Source: Biomaterials - October 15, 2021 Category: Materials Science Authors: Mingming Song Shiyao Zhang Zixuan Tao Jianning Li Yujie Shi Yonghong Xiong Wenxiang Zhang Chang Liu Siyu Chen Source Type: research

MiR-124 Prevents the Microglial Proinflammatory Response by Inhibiting the Activities of TLR4 and Downstream NLRP3 in Palmitic Acid-Treated BV2 Cells
AbstractNeuroinflammation is a mechanism by which obesity or a high-fat diet leads to cognitive impairment. MiR-124, a highly expressed microRNA in the brain, can alleviate neuroinflammation by regulating microglial activation, but its mechanism is unclear. The aim of the study was to explore whether miR-124 exerted this effect through TLR4/MyD88/NF- κB p65/NLRP3 signaling in palmitic acid-treated BV2 cells. Prepared BV2 cells were treated with palmitic acid to establish an in vitro model of a high-fat diet. An miR-124 mimic and inhibitor were adopted to upregulate and downregulate the expression of miR-124, respectively....
Source: Journal of Molecular Neuroscience - October 15, 2021 Category: Neuroscience Source Type: research

High-fat diet exacerbated BDE-209-induced hepatocyte apoptosis via intensifying the transfer of Ca < sup > 2+ < /sup > from endoplasmic reticulum to mitochondria
This study aimed to evaluate the hepatotoxicity of BDE-209 in lean and high-fat diet (HFD)-treated obese mice and elucidate the underlying mechanisms. Firstly, the increasing levels of triacylglycerol and proinflammatory factors in the liver and ALT and AST in serum demonstrated the hepatic damage caused by BDE-209 and further exacerbated by HFD. Tunel image revealed that BDE-209 induced more severe hepatocyte apoptosis with the assistant of HFD. Next, the mechanism analysis showed that the pro-apoptotic action of BDE-209 was in an endoplasmic reticulum (ER)/Ca2+ flux/mitochondria-dependent manner, concluded from the impai...
Source: Environmental Pollution - October 8, 2021 Category: Environmental Health Authors: Sunni Chen Siyan Che Shiqi Li Jin Wan Zheng Ruan Source Type: research

Therapeutic DNA vaccine encoding CEMIP (KIAA1199) ameliorates kidney fibrosis in obesity through inhibiting the Wnt/ β-catenin pathway
CONCLUSION: DNA vaccine targeting CEMIP/Wnt1/β-catenin pathway plays a novel strategy in nephropathy.GENERAL SIGNIFICANCE: Immune therapy might provide a new therapeutic option on nephropathy of obesity.PMID:34582938 | DOI:10.1016/j.bbagen.2021.130019
Source: Biochimica et Biophysica Acta - September 28, 2021 Category: Biochemistry Authors: Chao-Hung Chen Guan-Ming Ke Pi-Chen Lin Kun-Der Lin Source Type: research

Future ' Exceedingly Bright ' for Kidney Stone Prevention Future ' Exceedingly Bright ' for Kidney Stone Prevention
Some siRNA therapeutics, genetic therapy, and a new dietary supplement all look promising, a nephrolithiasis expert says.Medscape Medical News
Source: Medscape Medical News Headlines - September 13, 2021 Category: Consumer Health News Tags: Urology News Source Type: news

Increased Lipogenesis Is Critical for Self ‐Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega‐3 Fatty Acids
Breast cancer stem cells (CSC) have a distinct fatty acid profile due to the aberrant expressions of lipogenic enzymes (eg, FAS, SCD1, and FADS1/2), which are highly involved in sustaining their self-renewal, and proliferative capabilities. Omega-3 PUFA can effectively suppress the self-renewal and growth of breast CSC by downregulation of the lipogenic enzymes, especially SCD1. AbstractAberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addr...
Source: Stem Cells - September 6, 2021 Category: Stem Cells Authors: Haiqing Luo, Chih ‐Yu Chen, Xiangyong Li, Xin Zhang, Chien‐Wen Su, Yinhua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing Xuan Kang Tags: Cancer Stem Cells Source Type: research

Morin hydrate inhibits atherosclerosis and LPS-induced endothelial cells inflammatory responses by modulating the NF κB signaling-mediated autophagy
In conclusion, MO inhibits atherosclerosis in ApoE-/- mice and LPS-induced inflammatory responses by inhibiting the activation of the PI3K/Akt1/NFκB signaling pathway in a NFκB signaling-mediated autophagy way.PMID:34464886 | DOI:10.1016/j.intimp.2021.108096
Source: International Immunopharmacology - August 31, 2021 Category: Allergy & Immunology Authors: Qingyu Meng Luya Pu Qing Lu Baisen Wang Shuai Li Bin Liu Fan Li Source Type: research

Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration
We report that a high-fat/high-cholesterol diet leads to an i ncrease in S100A8 production in the brain. In CYP27Tg, we report an increase of S100A8 and its receptor RAGE in the hippocampus under elevated 27-OH in the brain. Using siRNA, we found that 27-OH upregulation of RAGE in astrocytes and neurons is mediated by the nuclear receptor RXRγ. Silencing RXRγ in neurons prevented 27-OH-mediated upregulation of RAGE. These results show that S100A8 alarmin and RAGE respond to high levels of 27-OH in the brain in both neurons and astrocytes through RXRγ. Our study supports the notion that 27-OH mediates detrimental effects...
Source: Molecular Neurobiology - August 27, 2021 Category: Neurology Source Type: research

HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis
Biochem Pharmacol. 2021 Jul 30:114716. doi: 10.1016/j.bcp.2021.114716. Online ahead of print.ABSTRACTA total number of 18 different isoforms of histone deacetylases (HDACs) which were categorized into 4 classes have been identified in human. HDAC3 is categorized as Class I HDACs and is closely related to the occurrence and development of atherosclerosis. Recent evidence has pointed to endothelial-to-mesenchymal transition (EndMT) as a key process in vascular inflammation in atherosclerosis. However, little is known about the effect of HDAC3 on EndMT in atherosclerosis. Therefore, we aimed to investigate the effect of HDAC3...
Source: Biochemical Pharmacology - August 2, 2021 Category: Drugs & Pharmacology Authors: Lifang Chen Chenxu Shang Bo Wang Guan Wang Zhen Jin Feng Yao Zejun Yue Liang Bai Rong Wang Sihai Zhao Enqi Liu Weirong Wang Source Type: research