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Total 445 results found since Jan 2013.
Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis
This study was designed to investigate the effects and underlying mechanisms of linc00657 in atherogenesis. The results showed that ox-LDL treatment significantly induced pyroptosis in human THP-1-derived macrophages. The secretion levels of LDH and pro-inflammatory factors were markedly enhanced, and the integrity of plasma membranes was disrupted in ox-LDL-treated THP-1-derived macrophages. These effects were significantly compensated after transfection with linc00657 siRNA and became more evident by linc00657 overexpression. Moreover, the effects of linc00657 overexpression on pyroptosis of THP-1-derived macrophages can...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Yin Liang Xiao-Dan Xu Xi Xu Yang-Bo Cai Zi-Xian Zhu Lin Zhu Kun Ren Source Type: research
Cancers, Vol. 15, Pages 4467: Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in A Colorectal Cancer Model
In this study, we combined DMR with immune checkpoint inhibitors (ICIs) in a model of colon adenocarcinoma. In vitro, we observed that MR increased the expression of MHC-I and PD-L1 in both mouse and human colorectal cancer cells. We also saw an increase in the gene expression of STING, a known inducer of type I interferon signaling. Inhibition of the cGAS–STING pathway, pharmacologically or with siRNA, blunted the increase in MHC-I and PD-L1 surface and gene expression following MR. This indicated that the cGAS–STING pathway, and interferon in general, played a role in the immune response to MR...
Source: Cancers - September 7, 2023 Category: Cancer & Oncology Authors: Lauren C. Morehead Sarita Garg Katherine F. Wallis Camila C. Simoes Eric R. Siegel Alan J. Tackett Isabelle R. Miousse Tags: Article Source Type: research
TRIM65 Suppresses oxLDL-induced Endothelial Inflammation by Interaction with VCAM-1 in Atherogenesis
CONCLUSION: Our studies indicate that TRIM65 attenuates the endothelial inflammatory response by targeting VCAM-1 for ubiquitination and provides a potential therapeutic target for the inhibition of endothelial inflammation in AS.PMID:37608612 | DOI:10.2174/0929867331666230822152350
Source: Current Medicinal Chemistry - August 23, 2023 Category: Chemistry Authors: Xiao-Feng Ma Yi-Ren Zhou Zhi-Xiang Zhou Hui-Ting Liu Bo-Bin Zhoua Nian-Hua Deng Kun Zhou Zhen Tian Ze-Fan Wu Xi-Yan Liu Ming-Gui Fu Zhi-Sheng Jiang Source Type: research
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding
In conclusion, miR-145 alleviates phenotype transition from contractile to synthetic type via ADAM17-mediated ACE2 shedding in VSMCs and retains the activation of ACE2-Ang-(1-7)-Mas axis, which may benefit the vascular structural remodeling in the metabolic hypertension.PMID:37521117 | PMC:PMC10374374 | DOI:10.1155/2023/9497716
Source: International Journal of Hypertension - July 31, 2023 Category: Cardiology Authors: Juan Wen Baiyi Tang Lan Guo Wei Chen Xiaohong Tang Source Type: research
