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Total 445 results found since Jan 2013.
Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease
In this study, we investigated the role of MIF in regulating JNK activation and high-fat fostered liver lipotoxicity during simultaneous exercise treatment. Fifteen mice were equally divided into three groups: normal diet, high-fat diet, and high-fat and exercise groups. High-fat feeding for extended periods elicited evident hyperlipemia, liver steatosis, and cell apoptosis in mice, with inhibited MIF and activated downstream MAPK kinase 4 phosphorylation and JNK. These effects were then reversed following prescribed swimming exercise, indicating that the advent of exercise could prevent liver lipotoxicity induced by lipid...
Source: Frontiers in Endocrinology - September 6, 2022 Category: Endocrinology Source Type: research
Indole-3-acetic acid improves the hepatic mitochondrial respiration defects by PGC1a up-regulation
In conclusion, our findings uncovered that I3A increased hepatic PGC1a expression, contributing to mitochondrial respiration improvement in NAFLD.PMID:35988807 | DOI:10.1016/j.cellsig.2022.110442
Source: Cellular Signalling - August 21, 2022 Category: Cytology Authors: Chen Zhang Qingsong Fu Kai Shao Limin Liu Xiaotian Ma Fengyi Zhang Xiaodong Zhang Liying Meng ChuanZhu Yan Xiaoyun Zhao Source Type: research
Acetate, a gut bacterial product, ameliorates ischemia-reperfusion induced acute lung injury in rats
In this study, we examine whether SCFAs have protective effects against IR-induced ALI and explore possible protective mechanisms. IR-induced ALI was established by 40 min ischemia followed by 60 min reperfusion in isolated perfused rat lungs. Rats were randomly assigned to one of six groups: control, control + acetate (400 mg/kg), IR, and IR + acetate at one of three dosages (100, 200, 400 mg/kg). Bronchoalveolar lavage fluids (BALF) and lung tissues were obtained and analyzed at the end of the experiment. In vitro, mouse lung epithelial cells (MLE-12) subjected to hypoxia-reoxygenation (HR) were pretreated with acetate (...
Source: International Immunopharmacology - August 14, 2022 Category: Allergy & Immunology Authors: Kuei-Yi Hung Shu-Yu Wu Hsin-Ping Pao Wen-I Liao Shi-Jye Chu Source Type: research
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress
Biochem Pharmacol. 2022 Aug 7:115203. doi: 10.1016/j.bcp.2022.115203. Online ahead of print.ABSTRACTResolvin D3 (RD3), an endogenous lipid mediator derived from omega-3 fatty acids, has been documented to attenuate inflammation in various disease models. Although it has been reported that omega-3 fatty acids attenuate metabolic disorders, the roles of RD3 in insulin signaling in skeletal muscle and hepatic lipid metabolism remain unclear. In the current study, we examined the role of RD3 in skeletal muscle insulin resistance and hepatic steatosis using in vitro and in vivo obesity models. In mouse primary hepatocytes, RD3 ...
Source: Biochemical Pharmacology - August 10, 2022 Category: Drugs & Pharmacology Authors: Heeseung Oh Wonjun Cho A M Abd El-Aty Cemil Bayram Ji Hoon Jeong Tae Woo Jung Source Type: research
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production
Cell Signal. 2022 Jul 26:110419. doi: 10.1016/j.cellsig.2022.110419. Online ahead of print.ABSTRACTIntraplaque hemorrhage (IPH) accelerates atherosclerosis progression. To scavenge excessive red blood cells (RBCs), vascular smooth muscle cells (VSMCs) with great plasticity may function as phagocytes. Here, we investigated the erythrophagocytosis function of VSMCs and possible regulations involved. Based on transcriptional microarray analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that genes up-regulated in human carotid atheroma with IPH were enriched in functions of phagocytic activiti...
Source: Atherosclerosis - July 29, 2022 Category: Cardiology Authors: Daorong Pan Wen Wu Guangfeng Zuo Xiangrong Xie Hui Li Xiaomin Ren Chaohua Kong Wenying Zhou Zihan Zhang Martin Waterfall Shaoliang Chen Source Type: research
H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes
CONCLUSIONS: Our results suggest a critical role for the lncRNA H19-HDAC6 axis in regulating IRS1 levels in the skeletal muscle during diabetes and therefore restoring normal H19 levels might hold a therapeutic potential for the management of aberrant skeletal muscle physiology during insulin resistance and type 2 diabetes.PMID:35842608 | DOI:10.1186/s10020-022-00507-3
Source: Molecular Medicine - July 16, 2022 Category: Molecular Biology Authors: Amit Kumar Malabika Datta Source Type: research
Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease
CONCLUSIONS: TLR4 could exacerbate tubular injury and fibrosis via GSDMD-mediated canonical pyroptosis pathway in T2DKD. Activation of GSDMD could inhibit apoptosis and activate pyroptosis, which may involve the potential switch mechanism between TLR4-mediated pyroptosis and apoptosis in T2DKD.PMID:35809639 | DOI:10.1016/j.abb.2022.109347
Source: Archives of Biochemistry and Biophysics - July 9, 2022 Category: Biochemistry Authors: Shuguang Yuan Youliang Wang Zheng Li Xiaojun Chen Panai Song Anqun Chen Zhong Qu Si Wen Hong Liu Xuejing Zhu Source Type: research
