Filtered By:
Nutrition: Carbohydrates

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 77 results found since Jan 2013.

Chitosan based pH-responsive polymeric prodrug vector for enhanced tumor targeted co-delivery of doxorubicin and siRNA
Publication date: Available online 29 July 2020Source: Carbohydrate PolymersAuthor(s): Tingsheng Yan, Siyuan Zhu, Wenxue Hui, Jinmei He, Zhonghua Liu, Jinju Cheng
Source: Carbohydrate Polymers - July 31, 2020 Category: Biomedical Science Source Type: research

MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity.
Abstract The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are serine/threonine protein kinases that are activated by the ERK1/2 (extracellular-regulated kinase) and p38α/β MAPK pathways. The MNKs have previously been implicated in metabolic disease and shown to mediate diet-induced obesity. In particular, knockout of MNK2 in mice protects from the weight gain induced by a high-fat diet. These and other data suggest that MNK2 regulates expansion of adipose tissue, a stable, long-term energy reserve that plays an important role in regulating whole-body energy homeostasis. Using the well-estab...
Source: The Biochemical Journal - July 9, 2020 Category: Biochemistry Authors: Merrett J, Xie J, Psaltis PJ, Proud CG Tags: Biochem J Source Type: research

Cationic Cellulose Nanocrystals Complexed with Polymeric siRNA for Efficient Anticancer Drug Delivery
Publication date: Available online 25 June 2020Source: Carbohydrate PolymersAuthor(s): Young Min Kim, Yoon Suk Lee, Taehyung Kim, Kyungjik Yang, Keonwook Nam, Deokyeong Choe, Young Hoon Roh
Source: Carbohydrate Polymers - June 27, 2020 Category: Biomedical Science Source Type: research

Hyaluronan decoration of milk exosomes directs tumor-specific delivery of doxorubicin.
This study demonstrates the potential use of HA-displaying mExo for tumor cell-specific drug delivery and this strategy should prove to be feasible for targeted cancer therapy. PMID: 32417443 [PubMed - as supplied by publisher]
Source: Carbohydrate Research - May 11, 2020 Category: Genetics & Stem Cells Authors: Li D, Yao S, Zhou Z, Shi J, Huang Z, Wu Z Tags: Carbohydr Res Source Type: research

Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation
ConclusionCollectively, these results show that targeting endothelial TXNIP in metabolic disorders is essential to maintaining endothelial function, vascular function and improving ischemia-induced revascularisation, making TXNIP a potential therapeutic target for therapy of vascular complications related to metabolic disorders.
Source: Angiogenesis - January 2, 2020 Category: Molecular Biology Source Type: research

Cancers, Vol. 12, Pages 30: Galectin-8 binds to the Farnesylated C-terminus of K-Ras4B and Modifies Ras/ERK Signaling and Migration in Pancreatic and Lung Carcinoma Cells
Becker Klaudia Giehl K-Ras is the most prominent driver of oncogenesis and no effective K-Ras inhibitors have been established despite decades of intensive research. Identifying new K-Ras-binding proteins and their interaction domains offers the opportunity for defining new approaches in tackling oncogenic K-Ras. We have identified Galectin-8 as a novel, direct binding protein for K-Ras4B by mass spectrometry analyses and protein interaction studies. Galectin-8 is a tandem-repeat Galectin and it is widely expressed in lung and pancreatic carcinoma cells. siRNA-mediated depletion of Galectin-8 resulted in increased K...
Source: Cancers - December 19, 2019 Category: Cancer & Oncology Authors: Christopher Meinohl Sarah J. Barnard Karin Fritz-Wolf Monika Unger Andreea Porr Marisa Heipel Stefanie Wirth Johannes Madlung Alfred Nordheim Andre Menke Katja Becker Klaudia Giehl Tags: Article Source Type: research

Dextran-based coacervate nanodroplets as potential gene carriers for efficient cancer therapy
Publication date: Available online 29 November 2019Source: Carbohydrate PolymersAuthor(s): Wang Chenglong, Xiong Shuhan, You Jiayi, Guan Wencai, Xu Guoxiong, Dou HongjingAbstractThe intractable toxicity of cationic polymers limits their applicability in gene transport and controlled release. In consideration of the good biocompatibility and biofunctionality of dextran, herein we design and synthesize two types of amino group-containing cationic copolymers based on dextran by the copolymerization of cationic monomers from dextran backbones. Additionally, allyl crosslinkers containing disulfide bonds were introduced into pol...
Source: Carbohydrate Polymers - December 1, 2019 Category: Biomedical Science Source Type: research

Preparation and Cell Activities of Lactosylated Curdlan-triornithine Nanoparticles for Enhanced DNA/siRNA Delivery in Hepatoma Cells
Publication date: Available online 27 August 2019Source: Carbohydrate PolymersAuthor(s): Xia Wang, Yuxuan Qi, Lixia Liu, Tsogzolmaa Ganbold, Huricha Baigude, Jingfen HanAbstractA long-anticipated cancer therapy would deliver the right type of therapeutic agents to the target in control with minimal systemic toxicity. The purpose of this study was to prepare lactosylated curdlan-triornithine nanocarriers (CTOLs), and target deliver gene to hepatoma cells. Structures and biophysical properties had been elucidated with physical and chemical methods. The results revealed that those functionalized polymers can completely conden...
Source: Carbohydrate Polymers - August 28, 2019 Category: Biomedical Science Source Type: research

Specifically-sized hyaluronan (35 kDa) prevents ethanol-induced disruption of epithelial tight junctions through a Layilin-dependent mechanism in Caco-2 cells.
CONCLUSION: Taken together, these data indicate that HA35 interacts with Layilin on intestinal epithelial cells and maintains intestinal tight junction integrity during short-term ethanol exposure. This article is protected by copyright. All rights reserved. PMID: 31237689 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - June 24, 2019 Category: Addiction Authors: Bellos DA, Sharma D, McMullen MR, Wat J, Saikia P, de la Motte CA, Nagy LE Tags: Alcohol Clin Exp Res Source Type: research

Advances in Chitosan-based Nanoparticles for Oncotherapy
Publication date: Available online 19 June 2019Source: Carbohydrate PolymersAuthor(s): Enhui Zhang, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Pengcheng LiAbstractChitosan has attracted considerable attention as an anti-tumor drug carrier material in recent years, which is due to its biocompatibility and biodegradability, as well as the simple and mild preparing techniques of drug-loaded nanoparticles. Chitosan-based nanoparticles can deliver various anti-tumor agents to specific tumor tissues by passive and active targeting mechanisms, including traditional chemotherapeutic agents, DNA or siRNA, proteins, photosensitize...
Source: Carbohydrate Polymers - June 19, 2019 Category: Biomedical Science Source Type: research

Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells
In conclusion, the targeting tLyp-1 exosomes are successfully engineered, and can be used for gene therapy with a high transfection efficiency. Therefore, the engineered targeting tLyp-1 exosomes offer a promising gene delivery platform for future cancer therapy.Graphical AbstractThe tLyp-1-lamp2b plasmid transfected HEK293T cells can secreted tumor targeting tLyp-1 exosomes. By electroporation technology, targeting tLyp-1 exosomes were loaded with siRNA. When targeting tLyp-1 exosome ruptured in cytoplasm, siRNA was loaded into the RNA-induced silencing complex (RISC). The sense (passenger) strand was degraded while the a...
Source: Asian Journal of Pharmaceutical Sciences - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Current Development of siRNA Bioconjugates: From Research to the Clinic
In this study, it was shown that the main factor determining the nature of the biodistribution of conjugates is their lipophilicity. Conjugates of siRNA with lower lipophilicity; i.e., derivatives of retinoic acid, lithocholic acid, and docosahexanoic acid with greater efficiency than cholesterol conjugates accumulated in the kidneys, bladder, and lungs of the mouse after subcutaneous injection (Biscans et al., 2018). This fact is consistent with previous data that showed that more lipophilic conjugates bind more efficiently to serum components, and thus are not excreted by the kidneys (Wolfrum et al., 2007; Osborn et al.,...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

FGF21 as Modulator of Metabolism in Health and Disease
In conclusion, FGF21 belongs to a promising class of cytokines that are induced in response to stress and that can be used as a drug, drug target, or through a biomarker, depending on the physio-pathological context. All these findings will become clear when FGF21 will be used as a therapeutic molecule, exploiting the beneficial effects of FGF21 for treating metabolic disease or when it will be blocked to ameliorate disease progression and the onset of disease. Author Contributions CT and MS wrote the manuscript. VR contributed to the discussion. Funding This work was supported from the AFM-Telethon (19524), Italian Mi...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
Conclusion In summary, this study is the first to combine metabolomics, transcriptomics, and genome-wide association studies in a porcine model. Our results improve understanding of the genetic regulation of metabolites which link to transcripts and finally biochemical-clinical parameters. Further, high-performance profiling of metabolites as intermediate phenotypes is a potentially powerful approach to uncover how genetic variation affects metabolic and health status. Our results advance knowledge in areas of biomedical and agricultural interest and identify potential correlates of biomarkers, SNPs-metabolites, SNPs-tran...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research