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Chemical Modifications in Nucleic Acids for Therapeutic and Diagnostic Applications
Chem Rec. 2022 Apr;22(4):e202100270. doi: 10.1002/tcr.202100270. Epub 2021 Dec 8.ABSTRACTThe last decade has witnessed the blooming of nucleic acids for therapeutic and diagnostic applications. In the present article, we describe the most important results from our group in this area covering the international context that surrounded this research. These include the study of modifications at the terminal and internal positions of siRNA duplexes to enhance nuclease resistance, increase loading of the antisense strand to RISC and avoid side effects such as activation of immune response and sense strand misloading. Then, we d...
Source: Chemical Record - April 7, 2022 Category: Chemistry Authors: Carme F àbrega Anna Avi ñó Ramon Eritja Source Type: research

Cancers, Vol. 14, Pages 1299: Role of GD3 Synthase ST8Sia I in Cancers
elannoy GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived cancers, and are directly involved in cell malignant properties, i.e., migration, invasion, stemness, and epithelial–mesenchymal transition. Since GD3 and GD2 levels are directly linked to GD3 synthase expression and activity, targeting GD3 synthase appears to be a promising strategy through which to interfere with ganglioside-associated malignant properties. We revie...
Source: Cancers - March 3, 2022 Category: Cancer & Oncology Authors: Angelina Kasprowicz Groux-Degroote Sophie Chann Lagadec Philippe Delannoy Tags: Review Source Type: research

RNA-Seq reveals the potential molecular mechanisms of bovine KLF6 gene in the regulation of adipogenesis
This study aims to investigate the influence of KLF6 (Kruppel Like Factor 6) and associated molecular mechanisms on lipid metabolism in bovine adipocytes. In the current study, KLF6 gene expression was down regulated via siRNA (small interfering RNA) in bovine adipocytes in vitro. Subsequently, adipogenic cells were collected from the culture media after 9 days, and subjected to fluorescent imaging and RNA sequencing. After confirming that KLF6 was down regulated in bovine adipocytes by siRNA, differential gene expression analysis was used to characterize the infuence of KLF6 on gene expression profiles in bovine adipocyte...
Source: International Journal of Biological Macromolecules - December 10, 2021 Category: Biochemistry Authors: Sayed Haidar Abbas Raza Rajwali Khan Gong Cheng Feng Long Sun Bing Ahmed A Easa Nicola M Schreurs Sameer D Pant Wenzhen Zhang Anning Li Linsen Zan Source Type: research

Knockdown of MUC16 (CA125) Enhances the Migration and Invasion of Hepatocellular Carcinoma Cells
As an important global medical problem, hepatocellular carcinoma (HCC) has been recognized as the most frequent primary liver cancer and a leading cause of death among patients with cirrhosis. Surveillance of HCC using serum markers aims to reduce the disease-related mortality of HCC. MUC16 (mucin 16, also known as carbohydrate antigen 125, CA125) has been predicted as a tumor biomarker for many cancer types. Based on the high frequency mutation rate in a database from the Cancer Genome Atlas (TCGA), we investigated the effects of MUC16 knockdown and the regulatory profile of MUC16 in HepG2 and Huh7 cell lines. Knockdown o...
Source: Frontiers in Oncology - June 2, 2021 Category: Cancer & Oncology Source Type: research

Inclisiran: First Approval
This article summarizes the milestones in the development of inclisiran leading to this first approval for primary hypercholesterolaemia or mixed dyslipidaemia.
Source: Drugs - February 23, 2021 Category: Drugs & Pharmacology Source Type: research

Biomedical application of Chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy
Publication date: Available online 16 February 2021Source: Carbohydrate PolymersAuthor(s): Milad Ashrafizade, Masoud Delfi, Farid Hashemi, Amirhossein Zabolian, Hossein Saleki, Morteza Bagherian, Negar Azami, Mahdi Vasheghani Farahani, Seyed omid Sharifzadeh, Soodeh Hamzehlou, Kiavash Hushmandi, Pooyan Makvandi, Ali Zarrabi, Michael R. Hamblin, Rajender S. Varma
Source: Carbohydrate Polymers - February 17, 2021 Category: Biomedical Science Source Type: research

Cell-selective siRNA delivery using glycosylated dynamic covalent polymers self-assembled in situ by RNA-templating.
Abstract Dynamic covalent libraries enable exploring complex chemical systems from which bioactive assemblies can adaptively emerge through template effects. In this work, we studied dynamic covalent libraries made of complementary bifunctional cationic peptides, yielding a diversity of species from macrocycles to polymers. Although polymers are typically expressed only at high concentration, we found that siRNA act as a template in the formation of dynamic covalent polymers at low concentration in a process guided by electrostatic binding. Using a glycosylated building block, we were able to show that this templa...
Source: Angewandte Chemie - December 8, 2020 Category: Chemistry Authors: Laroui N, Coste M, Su D, Ali L, Bessin Y, Barboiu M, Gary-Bobo M, Bettache N, Ulrich S Tags: Angew Chem Int Ed Engl Source Type: research

Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
Conclusion: Our data uncover a novel mechanism for hepatoprotective effects of Sal A against lipotoxicity both in livers from HFCD-fed mice and palmitic acid-treated hepatocytes.
Source: Frontiers in Pharmacology - November 30, 2020 Category: Drugs & Pharmacology Source Type: research

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