Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability
This study demonstrated the novel drug-drug C-ASDs systems is a promising formulation strategy for improved dissolution rate and enhanced physical stability of poorly soluble drugs.Graphical Abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - November 14, 2018 Category: Drugs & Pharmacology Source Type: research

A thorough analysis of the effect of surfactant/s on the solubility and pharmacokinetics of (S) -zaltoprofen
Publication date: Available online 2 November 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Cuong Viet Pham, Jong-Suep Baek, Jong-Hun Park, Sang-Hun Jung, Jong-Seong Kang, Cheong-Weon ChoAbstractUntil now, there are no publications about the preformulation studies on (S)-zaltoprofen ((S)-ZPF). Hence, we first investigated the solubility of (S)-ZPF, screened solubilizers and performed the pharmacokinetic study of (S)-ZPF in the presence of the solubilizers. The measurement of the solubility of (S)-ZPF in 26 different solvents was carried out, including D-alpha tocopheryl polyethylene glycol 1000 succinate (...
Source: Asian Journal of Pharmaceutical Sciences - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Monitoring film coalescence from aqueous polymeric dispersions using atomic force microscopy: surface topographic and nano-adhesion studies
Publication date: Available online 3 November 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ziyi Yang, Duncan Q.M. CraigAbstractThe aim of the investigation was to develop the use of topographic and nano-adhesion atomic force microscopy (AFM) studies as a means of monitoring the coalescence of latex particles within films produced from a pharmaceutically relevant aqueous dispersion (Eudragit®NE30D). Films were prepared via spin coating and analysed using AFM, initially via tapping mode for topographic assessment followed by force-distance measurements which allowed assessment of site-specific adhesion....
Source: Asian Journal of Pharmaceutical Sciences - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Improving the protective effects of aFGF for peripheral nerve injury repair using sulfated chitooligosaccharides
Publication date: Available online 1 November 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yanmei Liu, Fenglin Yu, Beibei Zhang, Meng Zhou, Yu Bei, Yifan Zhang, Jianzhong Tang, Yan Yang, Yadong Huang, Qi Xiang, Yueping Zhao, Qian Liang, Yang LiuAbstractInjury to the peripheral nerves can result in temporary or life-long neuronal dysfunction and subsequent economic or social disability. Acidic fibroblast growth factor (aFGF) promotes the growth and survival of neurons and is a possible treatment for peripheral nerve injury. Yet, the actual therapeutic utility of aFGF is limited by its short half-life and i...
Source: Asian Journal of Pharmaceutical Sciences - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

Current developments in drug delivery with thermosensitive liposomes
Publication date: Available online 31 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Hongshu Bi, Jianxiu Xue, Hong Jiang, Shan Gao, Dongjuan Yang, Yan Fang, Kai ShiAbstractThermosensitive liposomes (TSLs) have been an important research area in the field of tumor targeted chemotherapy. Since the first TSLs appeared that using 1,2-dipalmitoyl-sn-glyce-ro-3-phosphocholine (DPPC) as the primary liposomal lipid, many studies have been done using this type of liposome from basic and practical aspects. While TSLs composed of DPPC enhance the cargo release near the phase transition temperature, it has been...
Source: Asian Journal of Pharmaceutical Sciences - November 1, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation and in vitro-in vivo evaluation of intestinal retention pellets of Berberine chloride to enhance hypoglycemic and lipid-lowing efficacy
Publication date: Available online 25 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Guofei Li, Mingming Zhao, Xianying Su, Lin Song, Limei ZhaoAbstractBerberine chloride (BBR) is a pharmacokinetic profile of drug with poor bioavailability but good therapeutic efficacy, which is closely related to the discovery of BBR intestinal target. The major aim of this paper is to develop BBR intestinal retention type sustained-release pellets and evaluate their in vivo and in vitro behaviors base on the aspect of local action on intestinal tract. Here, wet milling technology is used to improve dissolution and...
Source: Asian Journal of Pharmaceutical Sciences - October 25, 2018 Category: Drugs & Pharmacology Source Type: research

Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: focus on recent advances
Publication date: Available online 22 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xiaoqian Niu, Jiejian Chen, Jianqing GaoAbstractNeurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington disease and amyotrophic lateral sclerosis throw a heavy burden on families and society. Related scientific researches make tardy progress. One reason is that the known pathogeny is just the tip of the iceberg. Another reason is that various physiological barriers, especially blood-brain barrier (BBB), hamper effective therapeutic substances from reaching site of action. Drugs in c...
Source: Asian Journal of Pharmaceutical Sciences - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells
In this study, we successfully incorporated a hydrophobic drug, bortezomib (Bor), into folic acid (FA)-conjugated Cs/Chs self-assembled NPs (Bor/Cs/Chs-FA) for colorectal cancer therapy. The particle size and polydispersity index of Bor/Cs/Chs-FA were ∼196.5 ± 1.2 nm and ∼0.21 ± 0.5, respectively. A pH-dependent release profile was observed, facilitating cancer cell-targeted drug release under an acidic tumor microenvironment. Moreover, in vitro data revealed enhanced cellular uptake and apoptosis in folate receptor-expressing colorectal cancer cells (HCT-116 and HT-29) as compared to that in lung can...
Source: Asian Journal of Pharmaceutical Sciences - October 21, 2018 Category: Drugs & Pharmacology Source Type: research

Cellulose based polymers in development of amorphous solid dispersions
Publication date: Available online 18 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Rahul B Chavan, Sneha Rathi, Vaskuri G S Sainaga Jyothi, Nalini R ShastriAbstractCellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, ...
Source: Asian Journal of Pharmaceutical Sciences - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Development of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation
This study focuses on separation of non-liposomal CPT-11, evaluation of the pharmacokinetics of free CPT-11 and total CPT-11 and bio-distribution after intravenous administration of CPT-11 liposome. Free CPT-11 in plasma was separated by solid-phase extraction (SPE). The amount of total CPT-11 and main metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) in plasma was quantified by ultra-performance liquid chromatography–MS/MS. The calibration curves fitted well and lower limit of quantitation for SN-38, free CPT-11, total CPT-11 and CPT-11 in tissue and were 5 ng/ml, 10 ng/ml, 4.44 ng/ml and 25 ng/ml respective...
Source: Asian Journal of Pharmaceutical Sciences - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Delivery of docetaxel using pH-sensitive liposomes based on D-α-tocopheryl poly(2-ethyl-2-oxazoline) succinate: Comparison with PEGylated liposomes
This study aimed to investigate the ability of the novel materials D-α-tocopheryl poly(2-ethyl-2-oxazoline) succinate (TPOS) to construct pH-sensitive liposomes. TPOS was initially synthesized and characterized by TLC, FTIR, and 1H-NMR. The buffering capacity of polyethylene glycol- distearoyl phosphatidylethanolamine (PEG-DSPE) and TPOS was determined by acid-base titration, and TPOS displayed a slower downtrend and gentler slope of titration curve than PEG-DSPE within pH 7.4–5.0. Studies on the in vitro drug release demonstrated that TPOS modified docetaxel (DOC) liposomes (TPOS-DOC-L) had a slower drug-relea...
Source: Asian Journal of Pharmaceutical Sciences - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound
In conclusion, this innovative foam dressing had potential to be a good candidate for wound treatment.Graphical abstractThe developed foam dressing consisted of three parts; natural polyols, silver nanoparticles and asiaticoside. Adding the natural polyols in polyurethane foam preparation was to increase hydrophilic properties and their characteristics were evaluated. The silver and asiaticoside were then impregnated and their releasing profiles were determined. The animal studies were performed to evaluate the efficacy and safety of the prepared foam dressings. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique
Publication date: Available online 12 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Wenxiang Dong, Xitong Su, Meng Xu, Mingming Hu, Yinghua Sun, Peng ZhangAbstractDue to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared through the solvent evaporation method, with Poloxamer 188 as hydrophilic carriers. This formulation was then characterized by scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction and fourier transform infrared spectros...
Source: Asian Journal of Pharmaceutical Sciences - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Modulating intestinal mucus barrier for nanoparticles penetration by surfactants
Publication date: Available online 12 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xin Zhang, Wei Dong, Hongbo Cheng, Meixia Zhang, Yongqiang Kou, Jian Guan, Qiaoyu Liu, Mingyue Gao, Xiuhua Wang, Shirui MaoAbstractImproving peroral delivery efficiency is always a persistent goal for both small-molecule and macromolecular drug development. However, intestinal mucus barrier which greatly impedes drug-loaded nanoparticles penetration is commonly overlooked. Therefore, in this study, taking fluorescent labeled PLGA (poly (lactic-co-glycolic acid)) nanoparticles as a tool, the influence of anionic and ...
Source: Asian Journal of Pharmaceutical Sciences - October 12, 2018 Category: Drugs & Pharmacology Source Type: research

A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform
In conclusion, the hybrid NLC-based hydrogel has a promising potential for application in ocular drug delivery.Graphical abstractAn innovative hybrid drug delivery platform: genipin-crosslinked dual pH- and thermo-sensitive hydrogel/nanostructured lipid carrier has been exploited for ocular delivery of baicalin. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - October 10, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation of a film-coated dutasteride tablet bioequivalent to a soft gelatin capsule (Avodart®): Effect of γ-cyclodextrin and solubilizers
Publication date: Available online 5 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mi-Hong Min, Jin-Hyong Park, Mi-Ran Choi, Jong-Hyun Hur, Byung-Nak Ahn, Dae-DuK KimABSTRACTThe aim of this study was to optimize a tablet formulation of dutasteride that is bioequivalent to a commercially available soft gelatin capsule (Avodart®). The effect of cyclodextrin on enhancing the aqueous solubility of dutasteride was investigated, after which the formulation was further optimized with solubilizing polymer and surfactant. Among the cyclodextrins tested, the highest solubility was observed when dutasteri...
Source: Asian Journal of Pharmaceutical Sciences - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid
Publication date: Available online 24 September 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Lingfei Han, Lejian Hu, Fulei Liu, Xin Wang, Xiaoxian Huang, Bowen Liu, Feng Feng, Wenyuan Liu, Wei QuAbstractThe application of paclitaxel (PTX) in clinic has been restricted due to its poor solubility. Several traditional nano-medicines have been developed to improve this defect, while they are still lack of tumor targeting ability and rapid drug release. In this work, an amphiphilic polymeric micelle of hyaluronic acid (HA) - all-trans-retinoid acid (ATRA) with a disulfide bond, was developed successfully for t...
Source: Asian Journal of Pharmaceutical Sciences - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Development of PLGA micro- and nanorods with high capacity of surface ligand conjugation for enhanced targeted delivery
In this study, we prepared anisotropic PLGA nanoparticles with abundant conjugatable surface functional groups by a film stretching-based fabrication method with poly (ethylene-alt-maleic acid) (PEMA). Scanning electron microscopy images showed that microrods and nanorods were successfully fabricated by the PEMA-based film stretching method. The presence of surface carboxylic acid groups was confirmed by confocal microscopy and zeta potential measurements. Using the improved film-stretching method, the amount of protein conjugated to the surface of nanorods was increased three-fold. Transferrin-conjugated, nanorods fabrica...
Source: Asian Journal of Pharmaceutical Sciences - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

PEPT1-mediated prodrug strategy for oral delivery of peramivir
Publication date: Available online 3 October 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yongbing Sun, Wei Gan, Mingdao Lei, Wei Jiang, Meng Cheng, Junwei He, Qi Sun, Wan Liu, Lvjiang Hu, Yi JinAbstractPeramivir was a novel and highly potent neuraminidase (NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability (only 3%) due to the high polarity (log P of −1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid este...
Source: Asian Journal of Pharmaceutical Sciences - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Delivery of docetaxel using pH-sensitive liposomes based on D-?-tocopheryl poly(2-ethyl-2-oxazoline) succinate: comparison with PEGylated liposomes
This study aimed to investigate the ability of the novel materials d-α-tocopheryl poly(2-ethyl-2-oxazoline) succinate (TPOS) to construct pH-sensitive liposomes. TPOS was initially synthesized and characterized by thin-layer chromatography (TLC), fourier transform infrared spectroscopy, and 1H-NMR. The buffering capacity of polyethylene glycol- distearoyl phosphatidylethanolamine (PEG-DSPE) and TPOS was determined by acid-base titration, and TPOS displayed a slower downtrend and gentler slope of titration curve than PEG-DSPE within pH 7.4-5.0. Studies on the in vitro drug release demonstrated that TPOS modified docet...
Source: Asian Journal of Pharmaceutical Sciences - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Triphenylphosphonium-modified mitochondria-targeted paclitaxel nanocrystals for overcoming multidrug resistance
Publication date: Available online 18 September 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xue Han, Ruijuan Su, Xiuqing Huang, Yingli Wang, Xiao Kuang, Shuang Zhou, Hongzhuo LiuAbstractMitochondria are currently known as novel targets for treating cancer, especially for tumors displaying multidrug resistance (MDR). This present study aimed to develop a mitochondria-targeted delivery system by using triphenylphosphonium cation (TPP+)-conjugated Brij 98 as the functional stabilizer to modify paclitaxel (PTX) nanocrystals (NCs) against drug-resistant cancer cells. Evaluations were performed on 2D monolayer...
Source: Asian Journal of Pharmaceutical Sciences - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Cooperative effect of polyvinylpyrrolidone and HPMC E5 on dissolution and bioavailability of nimodipine solid dispersions and tablets
In this study, SD of nimodipine (NMP) and corresponding tablets were prepared through solvent method and fluid bed granulating one step technique respectively. Discriminatory dissolution media were used to obtain reliable dissolution results. Meanwhile, the stability study of SDs was investigated with storage under high temperature and humidity conditions. Moreover, the solubility of SDs was measured to explore the effect of carriers. The preparations were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FTIR). Dramatical improvements in...
Source: Asian Journal of Pharmaceutical Sciences - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

MSNCs and MgO-MSNCs as drug delivery systems to control the adsorption kinetics and release rate of indometacin
Publication date: Available online 20 September 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xin Zheng, Shuang Feng, Xiudan Wang, Zhenning Shi, Yuling Mao, Qinfu Zhao, Siling WangAbstractMesoporous silica cocoon materials (MSNCs) and MgO doped mesoporous silica cocoons (MgO-MSNCs) with the cocoon-like hierarchical morphology and different alkalinities were synthesized as carriers for acidic drugs. Indomethacin (IMC) was selected as a model drug and loaded into carriers. All materials and the drug-loaded samples were characterized by nitrogen adsorption, FTIR spectroscopy, transmission electron microscopy ...
Source: Asian Journal of Pharmaceutical Sciences - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis
Publication date: Available online 18 September 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Prakash Thapa, Du Hyung Choi, Min-Soo Kim, Seong Hoon JeongAbstractThe current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets. The knowledge gained was intended to be used for Quality-by-Design based process design and optimization. The variables were selected based on the risk assessment as impeller speed, liquid addition rate, and wet massing time. Formulation compositions were kept constant to minimize their influence on granules p...
Source: Asian Journal of Pharmaceutical Sciences - September 18, 2018 Category: Drugs & Pharmacology Source Type: research

The appliances and prospects of aurum nanomaterials in biodiagnostics, imaging, drug delivery and combination therapy
Publication date: Available online 14 September 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Dan Yang, Feiyang Deng, Dechun Liu, Bo He, Bing He, Xing Tang, Qiang ZhangAbstractAurum nanomaterials (ANM), combining the features of nanotechnology and metal elements, have demonstrated enormous potential and aroused great attention on biomedical applications over the past few decades. Particularly, their advantages, such as controllable particle size, flexible surface modification, higher drug loading, good stability and biocompatibility, especially unique optical properties, promote the development of ANM in b...
Source: Asian Journal of Pharmaceutical Sciences - September 15, 2018 Category: Drugs & Pharmacology Source Type: research

The development of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation
This study focuses on separation of non-liposomal CPT-11, evaluation of the pharmacokinetics of free CPT-11 and total CPT-11 and bio-distribution after intravenous administration of CPT-11 liposome. Free CPT-11 in plasma was separated by solid-phase extraction (SPE). The amount of total CPT-11 and main metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) in plasma was quantified by ultra-performance liquid chromatography–MS/MS. The calibration curves fitted well and lower limit of quantitation for SN-38, free CPT-11, total CPT-11 and CPT-11 in tissue and were 5 ng/ml, 10 ng/ml, 4.44 ng/ml and 25 ng/ml respectively. The ...
Source: Asian Journal of Pharmaceutical Sciences - September 12, 2018 Category: Drugs & Pharmacology Source Type: research

A hybrid genipin-crosslinked dual-sensitive hydrogel /nanostructured lipid carrier ocular drug delivery platform
In conclusion, the hybrid NLC-based hydrogel has a promising potential for application in ocular drug delivery.Graphical Abstract. An innovative hybrid drug delivery platform: genipin-crosslinked dual pH- and thermo-sensitive hydrogel/nanostructured lipid carrier has been exploited for ocular delivery of baicalin (BN). (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

Extended Tacrolimus Release via the Combination of Lipid-based Solid Dispersion and HPMC Hydrogel Matrix Tablets
The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques. Tacrolimus solid dispersion was prepared using glycerylbehenate (Compritol® ATO888) and Pluronic F127 as the carrier materials with hot-melt method, which was then blended with hydrogel matrix materials, such as HPMC and lactose, the powders were directly compressed into tablets. In vitro drug release tests were carried out to evaluate the performance of the solid dispersions and the tablets. The dissolution rate...
Source: Asian Journal of Pharmaceutical Sciences - September 8, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes
In this study, the correlation between Kupffer cells (KCs) and ABC phenomenon has been studied by KCs-targeted liposomes inducing ABC phenomenon and KCs depletion. In other words, the 4-aminophenyl-α-D-mannopyranoside (APM) lipid derivative DSPE-PEG2000-APM (DPM), and 4-aminophenyl-β-L-fucopyranoside (APF) lipid derivative DSPE-PEG2000-APF (DPF) were conjugated and modified on alendronate sodium (AD) liposomes to specifically target and deplete KCs. The dual-ligand modified PEGylated liposomes (MFPL) showed stronger ability to damage KCs in vitro and in vivo, which also could indirectly illustrate...
Source: Asian Journal of Pharmaceutical Sciences - September 5, 2018 Category: Drugs & Pharmacology Source Type: research

Cyclodextrin/chitosan nanoparticles for oral ovalbumin delivery: Preparation, characterization and intestinal mucosal immunity in mice
In conclusion, our data suggested that CD/CS nanoparticles could serve as a promising antigen-delivery system for oral vaccination.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

Optimizing pH-sensitive and time-dependent polymer formula of colonic pH-responsive pellets to achieve precise drug release
In conclusion, ES100-ERS NCO colonic delivery system achieved reduced coating thickness and improved colonic targeting compared with traditional delivery system (ERS-ES100 TCO). In addition, the similarity factors (f2) value of sophoridine and matrine for investigated formulation were within 50-100 and> 80, demonstrating that sophoridine and matrine in all formulations achieved a synchronous release.Graphical abstractTASA(total alkaloids of sophora alopecuroides) pH-sensitive and time-dependent pellets were prepared by extrusion-spheronization coating with Eudragit RS30D and Eudragit S100. In order to achieve precise co...
Source: Asian Journal of Pharmaceutical Sciences - August 28, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of raw material variability of glipizide on the in vitro dissolution rate and in vivo bioavailability performance: the importance of particle size
The objective of this study was to understand the impact of active pharmaceutical ingredients (API) particle size on a re-developed generic product of glipizide and to improve its formulation so that it exhibits bioequivalent to that of the reference listed drug (RLD). Two commercial batches of APIs (API-1 and API-2) with the same polymorphism and one batch of home-made APIs (API-3) with super-small particle size were used in the present study. The in vitro dissolution profiles of the tested formulations were compared with the RLD in a series of dissolution media. Then, the impact of particle size on in vivo absorption was...
Source: Asian Journal of Pharmaceutical Sciences - August 28, 2018 Category: Drugs & Pharmacology Source Type: research

Nanomaterials for modulating innate immune cells in cancer immunotherapy
Publication date: Available online 23 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Quoc-Viet Le, Geon Yang, Yina Wu, Ho Won Jang, Mohammadreza Shokouhimehr, Yu-Kyoung OhAbstractCancer immunotherapy has been intensively investigated in both preclinical and clinical studies. Whereas chemotherapies use cytotoxic drugs to kill tumor cells, cancer immunotherapy is based on the ability of the immune system to fight cancer. Tumors are intimately associated with the immune system: they can suppress the immune response and/or control immune cells to support tumor growth. Immunotherapy has yielded promising ...
Source: Asian Journal of Pharmaceutical Sciences - August 24, 2018 Category: Drugs & Pharmacology Source Type: research

Double-layered osmotic pump controlled release tablets of actarit: In vitro and in vivo evaluation
Publication date: Available online 19 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yuenan Li, Hao Pan, Hongliang Duan, Jianting Chen, Zhihong Zhu, Jingxin Fan, Pingfei Li, Xinggang Yang, Weisan PanAbstractThe aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation; the pharmacokinetic study was performed in beagle dogs adopting actarit common tablets as reference tablets. ...
Source: Asian Journal of Pharmaceutical Sciences - August 20, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro/vivo assessment of praziquantel nanocrystals: Formulation, characterization, and pharmacokinetics in beagle dogs
Publication date: Available online 17 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ruyi Yang, Tao Zhang, Jiang Yu, Yan Liu, Yingli Wang, Zhonggui HeAbstractTo investigate the impact of particle size on in vitro/vivo performance of praziquantel (PZQ), nanocrystals (NCs) and microcrystals (MCs) of PZQ were prepared using the methods of wet milling and jet milling, respectively. PZQ NCs and MCs were characterized with dynamic light scattering, laser particle size analyzer, transmission electron microscopy, differential scanning calorimetry, X-ray powder diffraction and fourier transform infrared spect...
Source: Asian Journal of Pharmaceutical Sciences - August 17, 2018 Category: Drugs & Pharmacology Source Type: research

Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy
Publication date: Available online 16 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Shivani Verma, Puneet UtrejaAbstractOccurrence of skin fungal infections is increasing nowadays and their presence is more prominent in patients suffering from immunocompromised diseases like AIDS. Skin fungal infections are a major cause of visits by patients to dermatology clinics. Although, a large number of antifungal agents are available for treatment of skin fungal infections, but, their toxic profile and physicochemical characteristics reduce therapeutic outcome. When these antifungal agents are delivered topi...
Source: Asian Journal of Pharmaceutical Sciences - August 16, 2018 Category: Drugs & Pharmacology Source Type: research

A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres
Publication date: Available online 14 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mingzhu Ye, Hongliang Duan, Lixia Yao, Yicheng Fang, Xiaoyu Zhang, Ling Dong, Feifei Yang, Xinggang Yang, Weisan PanAbstractThe object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time (37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and...
Source: Asian Journal of Pharmaceutical Sciences - August 14, 2018 Category: Drugs & Pharmacology Source Type: research

Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
Publication date: Available online 9 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Zhenbao Li, Dan Li, Wenjuan Zhang, Peng Zhang, Qiming Kan, Jin SunAbstractPreformed albumin corona of albumin-nonselective nanoparticles (NPs) is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration. However, very few studies have concerned the preformed albumin corona of albumin-selective NPs. Herein, we report a novel type of albumin-selective NPs by decorating 6-maleimidocaproyl polyethylene glycol stearate (SA) onto PLGA NPs (SP NPs) surface, taking albumin-nonselective PL...
Source: Asian Journal of Pharmaceutical Sciences - August 9, 2018 Category: Drugs & Pharmacology Source Type: research

Special Issue: Pharmaceutical Innovation
Publication date: Available online 31 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Pornsak Sriamornsak, Duangratana ShuwisitkulAbstract“Pharmaceutical innovation” is an interdisciplinary area of the pharmaceutical sciences including drug development with a focus on manufacturing, process control, and technology, among many other subfields of research. In this special issue, we have invited all participants attended the International Conference and Exhibition on Pharmaceutical Sciences and Technology 2018 under the theme of pharmaceutical innovation and translational research for human hea...
Source: Asian Journal of Pharmaceutical Sciences - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Small GTPases: structure, biological function and its interaction with nanoparticles
Publication date: Available online 31 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Siyang Song, Wenshu Cong, Shurong Zhou, Yujie Shi, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He, Qiang ZhangAbstractSmall GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells. It plays an important role in cytoskeletal reorganization, cell polarity, cell cycle progression, gene expression and many other significant events in cells, such as the interaction with foreign particles. Therefore, it is of great scientific significance to understand the biological properties of small GTPases as well as t...
Source: Asian Journal of Pharmaceutical Sciences - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
In this study we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS). The formulation of the TMP and BN microemulsion (TEM-BN-ME) was optimized in in vitro skin permeation studies following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher (P
Source: Asian Journal of Pharmaceutical Sciences - July 29, 2018 Category: Drugs & Pharmacology Source Type: research

Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents
Publication date: Available online 27 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mei Lu, Qiujun Qiu, Xiang Luo, Xinrong Liu, Jing Sun, Cunyang Wang, Xiangyun Lin, Yihui Deng, Yanzhi SongAbstractAlthough active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly” phospholipids and active consti...
Source: Asian Journal of Pharmaceutical Sciences - July 27, 2018 Category: Drugs & Pharmacology Source Type: research

Research progress of in-situ gelling ophthalmic drug delivery system
Publication date: Available online 24 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe, Bing Zhang, Jing Ren, Jun Lu, Jiawei Li, Shouying Du, Zhidong LiuAbstractBlindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration...
Source: Asian Journal of Pharmaceutical Sciences - July 22, 2018 Category: Drugs & Pharmacology Source Type: research

Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry
This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Wes...
Source: Asian Journal of Pharmaceutical Sciences - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Welcome to this special issue of AJPS on Inhalation drug delivery
Publication date: Available online 8 September 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Philippe Rogueda, Hui Xin Ong, Oscar Liu, Darragh Murnane (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antiurolithiatic activity of Alternanthera tenella Colla in ethylene glycol induced urolithiasis in rats
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sahithi Adepu, Raviraj Anand Devkar, Shilpee Chaudhary, Manganahalli Manjunath Setty (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Phytochemical investigation and antihyperglycemic activity of leaves of Aegle marmelos (L.) Correa
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Soe Sandar Phyo, Win Myint, Khine Khine Lwin, Aye Kyi, Myint Myint Than (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective action of Gmelina arborea (bark) and Punica granatum (peel) extracts
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Pai Vasudev, C.S. Shreedhara, K.S. Chandrashekar, D. Yamini (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Physiological and gene expressional alternation in obesity animal model for ADME/PK characterization
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sung-Hoon Ahn (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Determination of N-trans-feruloyltyramine content and nitric oxide inhibitory and antioxidant activities of Tinospora crispa
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Attawadee SaeYoon, Bhudsaban Sukkarn, Wichit Nosoongnoen, Chutima Jantarat, Poonsit Hiransai, Pajaree Sakdiset, Jiraporn Chingunpitak, Sunita Makchuchit, Arunporn Itharat (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research