Welcome to this special issue of AJPS on Inhalation drug delivery
Publication date: Available online 8 September 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Philippe Rogueda, Hui Xin Ong, Oscar Liu, Darragh Murnane (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antiurolithiatic activity of Alternanthera tenella Colla in ethylene glycol induced urolithiasis in rats
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sahithi Adepu, Raviraj Anand Devkar, Shilpee Chaudhary, Manganahalli Manjunath Setty (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Phytochemical investigation and antihyperglycemic activity of leaves of Aegle marmelos (L.) Correa
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Soe Sandar Phyo, Win Myint, Khine Khine Lwin, Aye Kyi, Myint Myint Than (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective action of Gmelina arborea (bark) and Punica granatum (peel) extracts
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Pai Vasudev, C.S. Shreedhara, K.S. Chandrashekar, D. Yamini (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Physiological and gene expressional alternation in obesity animal model for ADME/PK characterization
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sung-Hoon Ahn (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Determination of N-trans-feruloyltyramine content and nitric oxide inhibitory and antioxidant activities of Tinospora crispa
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Attawadee SaeYoon, Bhudsaban Sukkarn, Wichit Nosoongnoen, Chutima Jantarat, Poonsit Hiransai, Pajaree Sakdiset, Jiraporn Chingunpitak, Sunita Makchuchit, Arunporn Itharat (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Factors affecting formation of microemulsions containing modified coconut oil
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sirikarn Pengon, Chutima Limmatvapirat, Sontaya Limmatvapirat (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation and optimization of fenofibrate loaded self-microemulsifying drug delivery system (SMEDDS) by application of box-behnken design
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Jin Wook Tak, Bijay Kumar Poudel, Pathak Shiva, Toe Kyung Go, Kyu bong Woo, Dong Shik Kim, Han-Gon Choi, Jee-Heon Jeong, Chul Soon Yong, Jong Oh Kim (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Optimization of trans-resveratrol extraction from peanut kernels using supercritical fluid extraction
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Kritamorn Jitrangsri, Amornrut Chaidedgumjorn, Malai Satiraphan (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design
Publication date: Available online 13 October 2017Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Thuy Tran, Thomas Rades, Anette MüllertzAbstractThe development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs is usually based on traditional one-factor-at-a-time approaches. These approaches may be inadequate to analyse the effect of each excipient and their potential interactions on the emulsion droplet size formed when dispersing the SNEDDS in an aqueous environment. The current study investigates the emulsion droplet sizes formed from SNEDDS c...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Development and bioequivalence study of potassium chloride extended release tablets
Publication date: Available online 23 October 2017Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Thu Van Le Thi, Nghiem Le Quan, Hau LeAbstractThe purposes of this study are to prepare the generic extended release tablet of potassium chloride (PC) 600 mg and to compare the absorption of potassium ion from the experimental tablets to that of Kaleorid® LP 600 mg (Leo Pharmaceutical Products, Denmark). Carnauba wax was used as retardant in the matrix core tablets. The core tablets were coated with blends of ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) to modulate the drug releas...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Challenges and trends in apomorphine drug delivery systems for the treatment of parkinson's disease
Publication date: Available online 6 December 2017Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Nrupa Borkar, Huiling Mu, René HolmAbstractParkinson's disease (PD) is a chronic debilitating disease affecting approximately 1 % of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has a similar chemical structure as the neurotransmitter dopamine and has been used for the treatment of advanced PD patients. In PD patients, apomorphine is normally administered subcutaneously with frequent injections because of the compound's extensive ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, in vitro and in vivo evaluation
In conclusion, nanocrystal is advantageous for transdermal delivery of MLX.Graphical AbstractMeloxicam nanocrystals were successfully prepared by the nanoprecipitation technique based on acid-base neutralization. Nanocrystals significantly increased both in vitro and in vivo transdermal permeation of meloxicam due to increased transdermal concentration gradient and facilitated follicular permeation. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing
This study was designed to investigate the effect of 3D TECA hydrogel on the inflammatory-induced senescence marker, and to assess the influence of the gel on the periodontal ligament fibroblasts (PDLFs) migration in wound healing in vitro. PDLFs were cultured with 20 ng/ml TNF-α to induce inflammation in the presence and absence of 50 µM 3D TECA gel for 14 d. The gel effect on the senescence maker secretory associated-β-galactosidase (SA-β-gal) activity was measured by a histochemical staining. Chromatin condensation and DNA synthesis of the cells were assessed by 4′,6-diamidino-2...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity
Publication date: Available online 27 December 2017Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Nawinda Chinatangkul, Chutima Limmatvapirat, Jurairat Nunthanid, Manee Luangtana-Anan, Pornsak Sriamornsak, Sontaya LimmatvapiratAbstractThe aim of this study was to elucidate the optimized fabrication factors influencing the formation and properties of shellac (SHL) nanofibers loaded with an antimicrobial monolaurin (ML). The main and interaction effects of formulation and process parameters including SHL content (35%–40% w/w), ML content (1%–3% w/w), applied voltage (9–27 kV) and flow rat...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation and evaluation of gels containing coconut kernel extract for topical application
Publication date: Available online 31 January 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Wantanwa Krongrawa, Sontaya Limmatvapirat, Nushjira Pongnimitprasert, Paranee Meetam, Chutima LimmatvapiratAbstractThe biological activity of coconut (Cocos nucifera L.) extracts from its kernels and various parts was reported by many previous studies, it is therefore believable that the extracts of its kernels might show some activities in topical formulations. Among several kernel extracts, the TC06 extract prepared by soaking the steamed coconut kernels in hot water showed the highest total phenolic content (6.98...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Design and characterization of clindamycin-loaded nanofiber patches composed of polyvinyl alcohol and tamarind seed gum and fabricated by electrohydrodynamic atomization
In this study, we developed a polymeric nanofiber patch (PNP) for topical disease treatment using electrohydrodynamic atomization (EHDA). The nanofibers were prepared using various concentrations of polyvinyl alcohol (PVA) and tamarind seed gum and loaded with clindamycin HCl as a model drug. The precursor polymer solutions were sprayed using the EHDA technique; the EHDA processing parameters were optimized to obtain blank and drug-loaded PNPs. The skin adherence, translucence, and ventilation properties of the prepared PNPs indicated that they are appropriate for topical application. The conductivity of the polymer soluti...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Predicting oral disintegrating tablet formulations by neural network techniques
Publication date: Available online 2 February 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Run Han, Yilong Yang, Xiaoshan Li, Defang OuyangAbstractOral disintegrating tablets (ODTs) are a novel dosage form that can  be dissolved on the tongue within 3 min or less especially for geriatric and pediatric patients. Current ODT formulation studies usually rely on the personal experience of pharmaceutical experts and trial-and-error in the laboratory, which is inefficient and time-consuming. The aim of current research was to establish the prediction model of ODT formulations with direct compressi...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery
Publication date: Available online 21 February 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Anna Slita, Anna Egorova, Eudald Casals, Anton Kiselev, Jessica M. RosenholmAbstractGene therapy using siRNA molecules is nowadays considered as a promising approach. For successful therapy, development of a stable and reliable vector for siRNA is crucial. Non-viral and non-organic vectors like mesoporous silica nanoparticles (MSN) are associated with lack of most viral vector drawbacks, such as toxicity, immunogenicity, but also generally a low nucleic acid carrying capacity. To overcome this hurdle, we here modif...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution
In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution (MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscopy, and then eight different concentrations of salicylic acid tablets were visualized by Raman mapping. MCR was applied to mapping data to expose the active pharmaceutical ingredients in the presence of other excipients by monitoring distribution maps and combination of FT-Raman mapping with MCR enabled the determination of lower...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Tablets of paliperidone using compression-coated technology for controlled ascending release
This study describes a method of preparation of paliperidone tablets using compression-coated technology for controlled ascending release. The core layer is made up of high viscosity HPC-H and coating layer of HPMC-K100M. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Takashi Osamura, Yoshiko Takeuchi, Risako Onodera, Masahiro Kitamura, Yoshiteru Takahashi, Kohei Tahara, Hirofumi TakeuchiAbstractWe previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Here, we examined whether this evaluation method can be used in the formulation design of tablet...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Role of clove oil in solvent exchange-induced doxycycline hyclate-loaded Eudragit RS in situ forming gel
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Thawatchai Phaechamud, Sai Myo Thurein, Takron ChantadeeAbstractSolvent exchange induced in situ forming gel (ISG) is the promising drug delivery system for periodontitis treatment owing to the prospect of maintaining an effective high drug level in the gingival crevicular fluid. In the present study, the influence of clove oil (CO) on the characteristics of doxycycline hyclate (DH)-loaded ISG comprising Eudragit RS (ERS) was investigated including viscosity/rheology, syringeability, in vitro gel formation/drug releas...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Two kinds of ketoprofen enteric gel beads (CA and CS-SA) using biopolymer alginate
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Bingchao Cheng, Dongyang Li, Qiye Huo, Qianqian Zhao, Qi Lan, Mengsuo Cui, Weisan Pan, Xinggang YangAbstractTo obtain expected rapid-release and sustained-release of ketoprofen gel beads, this paper adopted biopolymer alginate to prepare alginate beads and chitosan-alginate gel beads. Formulation factors were investigated and optimized by the single factor test. The release of ketoprofen from calcium alginate gel beads in pH 1.0 hydrochloric acid solution was less than 10% during 2 h, then in pH6.8 was about 95...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

ROS-responsive drug delivery systems for biomedical applications
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Wenhui Tao, Zhonggui HeAbstractIn the field of biomedicine, stimuli-responsive drug delivery systems (DDSs) have become increasingly popular due to their site-specific release ability in response to a certain physiological stimulus, which may result in both enhanced treatment outcome and reduced side effects. Reactive oxygen species (ROS) are the unavoidable consequence of cell oxidative metabolism. ROS play a crucial part in regulating biological and physiological processes, whereas excessive intracellular ROS usuall...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Combretastatin A4/poly(L-glutamic acid)-graft-PEG conjugates self-assembled to nanoparticles
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Yang Ou, Zhao-hui Tang, Lu Sun, Hai-yang Yu, Jia Li, Mei-hui Zhao, Hui XuAbstractCombretastatin A4 (CA4) possesses varying ability to cause vascular disruption in tumors, while the short half-life, low water solubility and deactivation of many CA4 analogs during storage limited its antitumor efficacy and drug stability. A novel macromolecular conjugate of CA4 (CA4-PL) was synthesized by covalent bonding of CA4 onto poly(L-glutamic acid)-graft-polyethylene glycol (PLG-g-PEG) via Yamaguchi reaction. The obtained CA4-PL ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Development of lamellar gel phase emulsion containing baru oil (Dipteryx alata Vog.) as a prospective delivery system for cutaneous application
Publication date: March 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 2Author(s): Cristhianne Moraes, Jorge L.V. Anjos, Monica Maruno, Antonio Alonso, Pedro Rocha-FilhoAbstractThe rational design of emulsions requires study of the main factors that influence their formation, physicochemical properties and, consequently, stability and performance. The use of vegetable oils in the pharmaceutical and cosmetic industries has recently become attractive. Dipteryx alata Vogel (D. alata) is an oleaginous species native to Brazil. The seeds of this species contain highly unsaturated oil with significant amo...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex
This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.Graphical AbstractFor improving the utilization of NK, a complex of NK-TUDCA to reduce the toxicity of intravenous NK injection, was designed by using NK as the cationic moiety and TUDCA as the anionic moiety. The NK-TUDCA reduced toxicity by the delayed release of NK from the complex and still possessed the inherent powerful efficiency of NK. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery
In this study, spray freeze drying was employed to prepare dry powder of small nucleic acids. Mannitol and herring sperm DNA were used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration were produced. The scanning electron microscope (SEM) images showed that the porosity of the particles increased as the solute concentration decreased. Powders prepared with solute concentration of 5% w/v were found to maintain a balance between porosity and robustness. Increasing concentration of DNA improved the aerosol performance of th...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Tunable and sustained-release characteristics of venlafaxine hydrochloride from chitosan–carbomer matrix tablets based on in situ formed polyelectrolyte complex film coating
In conclusion, CS–CBM matrix tablets are promising system to tune and control the release of highly water-soluble drugs with good system robustness.Graphical AbstractChitosan–carbomer matrix system is beneficial to tune and control drug release with good system robustness. The in vitro release method can be used as a tool for in vivo bioavailability predication, with level A in vitro and in vivo correlation (IVIVC) established successfully. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery
In this study, we investigated the nucleolus localization abilities and cellular internalization pathways of these two polymers in gene delivery. Each polymer condensed plasmid DNA (pDNA) and formed nanoparticle complexes, and then their transfection studies were performed in MCF-7 cells. Both complexes were found enriched in nucleolus after cellular transfection, and their transfection efficiencies were significantly improved when transfection was performed on MCF-7 cells arrested at M phase. The transfection efficiency of CAR-CBA-pDNA was inhibited by chlorpromazine, and cell endosomes were disrupted after being exposed ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Influence of solvent mixtures on HPMCAS-celecoxib microparticles prepared by electrospraying
This study demonstrated that electrospraying can be used to produce microparticles with tailored properties for pharmaceutical application by adjusting solvent selection.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Development of cryptotanshinone-loaded pellets for angina chronotherapy: In vitro/in vivo prediction and evaluation
In conclusion, this deconvolution-based method could be applied to adjust the in vivo performance of drugs for angina chronotherapy.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug
Publication date: Available online 13 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Patel Mayank, Hirlekar RajashreeAbstractThe purpose of the present study was to investigate the interaction of Cinnarizine (CIN) with Hydroxypropyl-β-Cyclodextrin (HPβCD) in the presence of Hydroxy Acids (HA). Various binary and ternary systems of CIN with HPβCD and HA were prepared by kneading and coevaporation methods. For the ternary systems HA were tried in three different concentrations. The interaction in solution phase was studied in detail by the phase solubility method and the solid phase inter...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Creation of an assessment system for measuring the bitterness of azithromycin-containing reverse micelles
Publication date: Available online 16 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ri Huang, Yadan Zhang, Tao Wang, Liao Shen, Zhen Zhang, Yang Wang, Dongqin QuanAbstractWe aimed to develop a novel method for assessing the bitterness of azithromycin-containing reverse micelles (AM-containing RMs). Azithromycin-containing reverse micelles were prepared by processing Lipoid E80 and medium chain triglycerides via a freeze-drying method. The bitterness threshold of azithromycin was determined by human taste test, and an equation was derived to correlate the azithromycin concentrations and bitterness sco...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Fabrication and characterization of spearmint oil loaded nanoemulsions as cytotoxic agents against oral cancer cell
Publication date: Available online 16 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sukannika Tubtimsri, Chutima Limmatvapirat, Siripan Limsirichaikul, Prasert Akkaramongkolporn, Yutaka Inoue, Sontaya LimmatvapiratAbstractSpearmint oil (SMO), a commonly used essential oil for oral care products, possesses various interesting functions, especially for anticancer property. However, the application of SMO for cancer treatment is limited due to water insoluble. In the present study, nanoemulsions, which have been widely accepted as dosage forms for poorly water-soluble drugs, were selected as candidate c...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Physicochemical properties of β-cyclodextrin solutions and precipitates prepared from injectable vehicles
Publication date: Available online 16 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sai Myo Thurein, Nutdanai Lertsuphotvanit, Thawatchai PhaechamudAbstractβ-Cyclodextrin (β-CyD) is cyclic oligosaccharide of a glucopyranose, containing a relatively hydrophobic central cavity and hydrophilic outer surface. However, the usefulness of β-CyD is limited owing to its low aqueous solubility whereas we found that its apparent high solubility was evident in some injectable solvents including 2-pyrrolidone (PYR), N-methyl pyrrolidone (NMP) and dimethyl sulfoxide (DMSO). Therefore, in the present...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of surfactant on the physical properties of coconut oil nanoemulsions
Publication date: Available online 17 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sirikarn Pengon, Nawinda Chinatangkul, Chutima Limmatvapirat, Sontaya LimmatvapiratAbstractThe aim of this study was to develop the water compatible form of coconut oil through nano-emulsification. The effect of different types and amounts of surfactants on the physical characteristics of nanoemulsions containing coconut oil was investigated. Coconut oil nanoemulsions containing varied amounts of surfactants including polyethylene glycol octyl phenyl ether (PGO), polyoxyethylene sorbitan monostearate (POS), polyethyle...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced digestion inhibition and mucus penetration of F127-modified self-nanoemulsions for improved oral delivery
Publication date: Available online 17 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Wenyi Song, Yuting Yang, Miaorong Yu, Quanlei Zhu, Mohammadali Soleimani Damaneh, Haijun Zhong, Yong GanAbstractSelf-nanoemulsifying systems (SNEs) have excellent ability to improve the solubility of poorly water-soluble drugs (PWSD). However, SNEs are likely to be degraded in gastrointestinal (GIT) when their surface is recognized by lipase/co-lipase enzyme complex, resulting in rapid release and precipitation of encapsulated drugs. The precipitates are then captured and removed by intestinal mucus, reducing the deli...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors
This study was aiming to investigate the potential of concurrent delivery of resveratrol (RES) and docetaxel (DTX) via polymeric nanocarriers to treat breast cancer. To this end, methoxyl poly(ethylene glycol)-poly(d,l-lactide) copolymer (mPEG-PDLA) was prepared and characterized using FTIR and 1H NMR, and their molecular weights were determined by GPC. Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line (MCF-7 cells). Subsequently, RES and DTX were loaded in the mPEG-PDLA micelles simultaneously, and the morpho...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes
Publication date: Available online 17 March 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Thanaporn Amnuaikit, Tunyaluk Limsuwan, Pasarat Khongkow, Prapaporn BoonmeAbstractTopical administration of phenylethyl resorcinol (PR) has attracted much attention as skin lightening agent with potent anti-tyrosinase activity. Two novel types of elastic carriers were developed to overcome the limitation of PR as topical delivery by increasing the solubility, stability and decreasing skin irritation compared to conventional liposomes. In addition, it also promotes skin penetration of PR to reach deep skin layer at the...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Use of seed gums from Tamarindus indica and Cassia fistula as controlled-release agents
The objective of the present study was to characterize and evaluate crude and carboxymethylated gums from T. indica and C. fistula seeds to achieve the controlled-release of diclofenac sodium (DS) in matrix tablet form. Both crude and carboxymethylated gums were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The results revealed that the gums were successfully modified by carboxymethylation and that the modified gums were amorphous in structure and had better flow properties. The carboxymethylated gums from both plant seeds did not exhibit cytotoxicity at conc...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Novel technique of insulin loading into porous carriers for oral delivery
In this study, we prepared chitosan coated porous poly (d, l-lactide-co-glycolide) (PLGA) microparticles (MPs) loaded with insulin using a novel loading technique; double freeze-drying. The results showed a significant increase in drug loading using only 5 mg/ml initial insulin concentration and conveyed a sustained drug release over uncoated MPs. Furthermore, SEM and confocal microscopy confirmed pore blocking and insulin accumulation within the MPs respectively. The oral pharmacodynamic data on rats also proved the preservation of insulin bioactivity after formulation. Finally, the new coating technique proved to be ef...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Disulfiram thermosensitive in-situ gel based on solid dispersion for cataract
Publication date: Available online 23 April 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Chunjuan Zhang, Tonghua Xu, Donglei Zhang, Wei He, Siling Wang, Tongying JiangAbstractTo improve the corneal permeability and water-solubility of disulfiram (DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF (DSFSD) by hot melt method. The DSFSD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amorphous in DSFSD. The DSFSD was added to borate buffer solution (BBS) contained 20% poloxamer P407 and 1.2% poloxamer P188 to form in-situ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Investigating the molecular dissolution process of binary solid dispersions by molecular dynamics simulations
Publication date: May 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 3Author(s): TengIan Chan, Defang OuyangAbstractDissolution molecular mechanism of solid dispersions still remains unclear despite thousands of reports about this technique. The aim of current research was to investigate the molecular dissolution mechanism of solid dispersions by molecular dynamics simulations. The formation of ibuprofen/polymer solid dispersions was modeled by the simulated annealing method. After that, the models of solid dispersions were immersed into the water box with 25–30 Å thicknesses and ...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Systematically optimized topical delivery system for Loperamide hydrochloride: Formulation design, in vitro and in vivo biopharmaceutical evaluation
This study aimed to develop a suitable topical delivery system containing diethylene glycol monoethyl ether (DGME) for Loperamide hydrochloride (Lop). Two factors, three levels Central-Composite design were applied by generating a quadratic polynomial equation to form contour plots and response surface for prediction of responses as two selected independent variables with EtOH-DGME ratio and EtOH concentration. The response variables flux and skin retention were determined in in vitro hairless mouse skin model. The selected optimum formulation was evaluated for the skin transport characteristics by developing dermatokineti...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Model evaluation for the prediction of solubility of active pharmaceutical ingredients (APIs) to guide solid–liquid separator design
Publication date: May 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 3Author(s): Kuveneshan Moodley, Jürgen Rarey, Deresh RamjugernathAbstractThe assumptions and models for solubility modelling or prediction in systems using non-polar solvents, or water and complex triterpene and other active pharmaceutical ingredients as solutes aren't well studied. Furthermore, the assumptions concerning heat capacity effects (negligibility, experimental values or approximations) are explored, using non-polar solvents (benzene), or water as reference solvents, for systems with solute melting points in the ran...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?
Publication date: May 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 3Author(s): Yanan Jin, Juanjuan Jia, Chan Li, Jianqi Xue, Jiabei Sun, Kaiyuan Wang, Yaling Gan, Jing Xu, Yaqin Shi, Xingjie LiangAbstractEndotoxin detection is an important step in drug characterization. Herein we found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride (CPT-11) and an amphiphilic molecule DSPE-mPEG2000 can interfere with the limulus amebocyte lysate assay (LAL). Furthermore, the rabbit pyrogen test (RPT) results indicated that at a relatively high dosage, the drug irinotecan hydrochl...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Activity of Brucea javanica oil emulsion against gastric ulcers in rodents
Publication date: May 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 3Author(s): Qian Li, Linglong Yang, Linlin Fan, Chen Liang, Qiujv Wang, Huimin Wen, Jinwei Dai, Xin Li, Yuyang ZhangAbstractThe present study aims to investigate the gastroprotective effect of Brucea javanica oil emulsion (BJOE) in animals. Gastroprotective potential of BJOE was studied on absolute ethanol, aspirin, reserpine and restraint plus water immersion-induced gastric ulcers in mice as well as glacial acetic acid (GAA) and pyloric ligation (PL)-induced gastric ulcers in rats. Except for ulcer scores, total acidity as well a...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Glycosylated and non-glycosylated quantum dot-displayed peptides trafficked indiscriminately inside lung cancer cells but discriminately sorted in normal lung cells: An indispensable part in nanoparticle-based intracellular drug delivery
Publication date: May 2018Source: Asian Journal of Pharmaceutical Sciences, Volume 13, Issue 3Author(s): Roger Salvacion TanAbstractDifference in sub-cellular trafficking of glycosylated and naked peptides, between normal and lung cancer cells, was established. Normal lung tissue discriminately sorted glycosylated from non-glycosylated peptides by allowing golgi localization of the glycosylated peptides while restricting golgi entry of the naked peptides. This mechanism was surprisingly not observed in its cancer cell counterpart. Lung cancer cells tend to allow unrestricted localization of both glycosylated and naked pept...
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research