Filtered By:
Infectious Disease: Enterovirus

This page shows you your search results in order of date.

Order by Relevance | Date

Total 22 results found since Jan 2013.

Targeting HDAC11 activity by FT895 Restricts EV71 Replication
Virus Res. 2023 Apr 4:199108. doi: 10.1016/j.virusres.2023.199108. Online ahead of print.ABSTRACTEnterovirus 71 (EV71) infection mainly causes hand, foot, and mouth disease (HFMD) and remains a serious public health problem to the children under the age of 5. Until now, there is no specific drug to treat HFMD in clinical and there is an urgent to explore the new target and the new drug to address clinical challenges. At present, we found histone deacetylase 11 (HDAC11) involves in supporting EV71 replication. We also used HDAC11 siRNA and an HDAC11 inhibitor FT895 to downregulate HDAC11 expression and found that targeting ...
Source: Virus Research - April 6, 2023 Category: Virology Authors: Hong Xie Enhui Yang Chaoyong Wang Chunyan Peng Lianfu Ji Source Type: research

Viruses, Vol. 15, Pages 785: EV-A71 Mechanism of Entry: Receptors/Co-Receptors, Related Pathways and Inhibitors
nhong Wei Enterovirus A71, a non-enveloped single-stranded (+) RNA virus, enters host cells through three stages: attachment, endocytosis and uncoating. In recent years, receptors/co-receptors anchored on the host cell membrane and involved in this process have been continuously identified. Among these, hSCARB-2 was the first receptor revealed to specifically bind to a definite site of the EV-A71 viral capsid and plays an indispensable role during viral entry. It actually acts as the main receptor due to its ability to recognize all EV-A71 strains. In addition, PSGL-1 is the second EV-A71 receptor discovered. Unlike hS...
Source: Viruses - March 18, 2023 Category: Virology Authors: Kanghong Hu Rominah Onintsoa Diarimalala Chenguang Yao Hanluo Li Yanhong Wei Tags: Review Source Type: research

Long non-coding RNA SNHG9 regulates viral replication in rhabdomyosarcoma cells infected with enterovirus D68 via miR-150-5p/c-Fos axis
ConclusionOur findings indicate that the SNHG9/miR-150-5p/c-Fos axis influences EV-D68 replication in host cells and that SNHG9 may be a possible target for anti-EV-D68 infection therapies.
Source: Frontiers in Microbiology - January 19, 2023 Category: Microbiology Source Type: research

Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases
Curr Res Chem Biol. 2022;2:100021. doi: 10.1016/j.crchbi.2022.100021. Epub 2022 Feb 1.ABSTRACTViral diseases are prominent among the widely spread infections threatening human well-being. Real-life clinical successes of the few available therapeutics are challenged by pathogenic resistance and suboptimal delivery to target sites. Nanotechnology has aided the design of functionalised and non-functionalised Au and Ag nanobiomaterials through physical, chemical and biological (green synthesis) methods with improved antiviral efficacy and delivery. In this review, innovative designs as well as interesting antiviral activities ...
Source: Herpes - July 11, 2022 Category: Infectious Diseases Authors: Yusuf Oloruntoyin Ayipo Ajibola Abdulahi Bakare Umar Muhammad Badeggi Akeem Adebayo Jimoh Amudat Lawal Mohd Nizam Mordi Source Type: research

Enterovirus A71 2B Inhibits Interferon-Activated JAK/STAT Signaling by Inducing Caspase-3-Dependent Karyopherin- α1 Degradation
In this report, we showed that 2B, a non-structural protein of EV-A71, was critical to the suppression of the IFN-α-induced type I response in infected cells. Among viral proteins, 2B was the only one that was involved in the degradation of KPNA1, which impeded the formation of the p-STAT1/2/KPNA1 complex and blocked the translocation of p-STAT1/2 into the nucleus upon IFN-α stimulation. Degradation of KPNA1 induced by 2B can be inhibited in the cells pre-treated with Z-DEVD-FMK, a caspase-3 inhibitor, or siRNA targeting caspase-3, indicating that 2B-induced degradation of KPNA1 was caspase-3 dependent. The mechanism by ...
Source: Frontiers in Microbiology - December 21, 2021 Category: Microbiology Source Type: research

GSE179496 Targeting the Viral Suppressor of RNAi Provides a Novel Strategy for Antiviral Therapy
Contributors : Yuan Fang ; Zezhong Liu ; Yang Qiu ; Jing Kong ; Yuhong Fu ; Yujie Liu ; Chong Wang ; Jia Quan ; Qian Wang ; Wei Xu ; Lei Yin ; Jie Cui ; Yi Xu ; Stephen Curry ; Shibo Jiang ; Lu Lu ; Xi ZhouSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Enterovirus A71RNA interference (RNAi) is an antiviral immunity conserved in diverse eukaryotes including mammals, while viruses encodes viral suppressors of RNAi (VSRs) as countermeasures. However, the physiological impact of RNAi on viral infection in mammals has not been fully assessed, and it also remains unknown whether antiviral RNAi can...
Source: GEO: Gene Expression Omnibus - July 31, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Enterovirus A71 Source Type: research

BNIP3 deletion ameliorated enterovirus 71 infection-induced hand, foot and mouth disease via inhibiting apoptosis, autophagy, and inflammation in mice.
Abstract Bcl2/adenovirus E1B protein-interacting protein 3 (BNIP3) plays a key role in cellular response to stress by regulating apoptosis and selective autophagy. The present study aimed to determine the effects of BNIP3 on enterovirus (EV) 71 infection-induced hand, foot and mouth disease (HFMD), and the apoptosis, autophagy and inflammatory in mice and SH-SY5Y human neuroblastoma cell line. Neonatal BALB/c mice were injected with EV 71 strain to induce the HFMD. Western blotting and ELISA were used to measure the protein expression and cytokine levels. The BNIP3 mRNA and protein levels in the brain were increas...
Source: International Immunopharmacology - July 23, 2020 Category: Allergy & Immunology Authors: Zhu L, Hao X, Cao J, Xie X, Wang H Tags: Int Immunopharmacol Source Type: research

Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.
Abstract Valosin-containing protein (VCP) plays roles in various cellular activities. Recently, Enterovirus A71 (EVA71) infection was found to hijack the VCP protein. However, the mechanism by which VCP participates in the EVA71 life cycle remains unclear. Using chemical inhibitor, RNA interference and dominant negative mutant, we confirmed that the VCP and its ATPase activity were critical for EVA71 infection. To identify the factors downstream of VCP in enterovirus infection, 31 known VCP-cofactors were screened in the siRNA knockdown experiments. The results showed that UFD1 (ubiquitin recognition factor in ER ...
Source: Virus Research - April 10, 2020 Category: Virology Authors: Yan J, Wang M, Wang M, Dun Y, Zhu L, Yi Z, Zhang S Tags: Virus Res Source Type: research

A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis.
Abstract Almost a billion people worldwide are chronically undernourished. Herein, using a mouse model of coxsackievirus B3 (CVB3) infection, we report that a single day of food restriction (FR) markedly increases susceptibility to attenuated enterovirus infection, replication, and disease. These "pro-viral" effects, which are rapidly-reversed by the restoration of food, are mediated by several genes whose expression is altered by FR, and which support CVB3 replication. Central to this is TFEB, a protein whose expression and activation status are rapidly increased by FR. TFEB, which regulates the transcription of ...
Source: Autophagy - February 3, 2020 Category: Cytology Authors: Alirezaei M, Flynn CT, Garcia SD, Kimura T, Whitton JL Tags: Autophagy Source Type: research

Susceptibility of Enterovirus-D68 to RNAi-mediated antiviral knockdown
Publication date: Available online 20 July 2019Source: Antiviral ResearchAuthor(s): Nicholas Klaiber, Michael A. McVoy, Wei ZhaoAbstractEnterovirus D68 (EV-D68) represents an emerging pathogen which has demonstrated a capacity for causing epidemic illness in pediatric and immunocompromised patients. With no effective antiviral treatment available, therapeutic interventions are currently limited to supportive care. Utilizing available genomic sequences from the 2014 B3 Epidemic EV-D68 clade and the 1962 Fermon EV-D68 strains, we performed in silico comparative genomic analysis, identifying several islands of phylogenetic co...
Source: Antiviral Therapy - July 21, 2019 Category: Virology Source Type: research

Susceptibility of Enterovirus-D68 to RNAi-mediated antiviral knockdown.
Abstract Enterovirus D68 (EV-D68) represents an emerging pathogen which has demonstrated a capacity for causing epidemic illness in pediatric and immunocompromised patients. With no effective antiviral treatment available, therapeutic interventions are currently limited to supportive care. Utilizing available genomic sequences from the 2014 B3 Epidemic EV-D68 clade and the 1962 Fermon EV-D68 strains, we performed in silico comparative genomic analysis, identifying several islands of phylogenetic conservation within the viral RNA-dependent RNA polymerase gene. The effects of transfecting short-interfering double-st...
Source: Antiviral Research - July 19, 2019 Category: Virology Authors: Klaiber N, McVoy MA, Zhao W Tags: Antiviral Res Source Type: research

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - December 30, 2018 Category: Infectious Diseases Source Type: research

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71infections in vitro
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - December 22, 2018 Category: Infectious Diseases Source Type: research