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Infectious Disease: Helicobacter Pylori
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Total 17 results found since Jan 2013.

Notch Signaling Ligand Jagged1 Enhances Macrophage-Mediated Response to Helicobacter pylori
Helicobacter pylori (H. pylori) is one of the gram-negative bacteria that mainly colonize the stomach mucosa and cause many gastrointestinal diseases, such as gastritis, peptic ulcer, and gastric cancer. Macrophages play a key role in eradicating H. pylori. Recent data have shown that Notch signaling could modulate the activation and bactericidal activities of macrophages. However, the role of Notch signaling in macrophages against H. pylori remains unclear. In the present study, in the co-culture model of macrophages with H. pylori, the inhibition of Notch signaling using γ-secretase decreased the expression of inducible...
Source: Frontiers in Microbiology - July 8, 2021 Category: Microbiology Source Type: research

Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR- γ and SOCS1 induction.
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. J Clin Biochem Nutr. 2020 Nov;67(3):248-256 Authors: Park JM, An JM, Han YM, Surh YJ, Hwang SJ, Kim SJ, Hahm KB Abstract The health beneficial effects of walnut plentiful of n-3 polyunsaturated fatty acid had been attributed to its anti-inflammatory and anti-oxidative properties against various clinical diseases. Since we have published Fat-1 transgenic mice overexpressing 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric pat...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Overexpression of Rictor protein and Rictor-H. pylori interaction impact on tumor progression and prognosis in patients with gastric cancer.
CONCLUSION: Our results demonstrate that Rictor, acting as an oncogene, might be a potential prognostic biomarker and therapeutic target in GC. We suggest that Rictor expression and H. pylori status may be a prognostic marker in gastric cancer. PMID: 32588907 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - June 27, 2020 Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research

Helicobacter Pylori Induces GATA3-Dependent Chitinase 3 Like 1 (CHI3L1) Upregulation and Contributes to Vascular Endothelial Injuries.
CONCLUSIONS H. pylori impaired vascular endothelial function. This might be due to the H. pylori-induced increased expression of GATA3, as well as the GATA3 mediated upregulated CHI3L1 and activation of the p38 MAPK pathway. PMID: 31256192 [PubMed - in process]
Source: Medical Science Monitor - July 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Autophagy Is a Defense Mechanism Inhibiting Invasion and Inflammation During High-Virulent Haemophilus parasuis Infection in PK-15 Cells
In this study, we sought to investigate whether SH0165 (serovar 5, high-virulent strain) and HN0001 (serovar 6, non-virulent strain) infection induces autophagy and the specific role of autophagy in bacterial invasion and inflammation during H. parasuis infection. Moreover, we explored the mechanism underlying autophagy regulated inflammation through inflammatory signaling cascades during H. parasuis infection. This observation could provide useful information for further understanding the role of autophagy in H. parasuis infection and improve our knowledge of new strategies against this pathogen. Materials and Methods B...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research

The effect of Helicobacter pylori on the expression of FRA-1 in gastric epithelial cells and its mechanism
Publication date: Available online 23 February 2019Source: Microbial PathogenesisAuthor(s): Yang Yang, Ke Dong, Shihe ShaoAbstractGastric cancer is a major global health threat and is often related with Helicobacter pylori (H. pylori) infection. FRA-1 is a subunit of the activator protein-1 transcription factor complex, which played a central role in cell proliferation and migration. It has also been implicated in stomach inflammation and malignancy. The present study aimed to clarify the relationship between H. pylori infection and production of FRA-1 in controlling cell proliferation and migration and its molecular mecha...
Source: Microbial Pathogenesis - February 25, 2019 Category: Infectious Diseases Source Type: research

microRNA-29a-3p, Up-Regulated in Human Gastric Cells and Tissues with < b > < i > H.Pylori < /i > < /b > Infection, Promotes the Migration of GES-1 Cells via A20-Mediated EMT Pathway
Conclusion: The miR-29a-3p may act as a tumor promotive miRNA by regulating cells migration through directly targeting of A20 gene in human gastric epithelial cells infected withH.pylori.Cell Physiol Biochem 2018;51:1250 –1263
Source: Cellular Physiology and Biochemistry - November 28, 2018 Category: Cytology Source Type: research

Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes.
Authors: Maués JHDS, Ribeiro HF, Pinto GR, Lopes LO, Lamarão LM, Pessoa CMF, Moreira-Nunes CFA, de Carvalho RM, Assumpção PP, Rey JA, Burbano RMR Abstract MYC is an oncogene responsible for excessive cell growth in cancer, enabling transcriptional activation of genes involved in cell cycle regulation, metabolism, and apoptosis, and is usually overexpressed in gastric cancer (GC). By using siRNA and Next-Generation Sequencing (NGS), we identified MYC-regulated differentially expressed Genes (DEGs) in three Brazilian gastric cancer cell lines representing the histological subtypes of GC (diffuse, intestinal, and ...
Source: Canadian Journal of Gastroenterology - November 11, 2018 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The leukocyte-associated immunoglobulin (Ig) –like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in THP-1 cells after Helicobacter pylori infection
Conclusion These results together indicated that LAIR-1 modulated cell apoptosis and inflammatory cytokines secretion in THP-1 cells, which might help sustain inflammation and prevent removal of the bacteria by the immune responses.
Source: Microbial Pathogenesis - June 19, 2017 Category: Infectious Diseases Source Type: research

MicroRNA ‐3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip‐α, by targeting TRAF3
ConclusionsTaken all together, Tip‐α might activate NF‐κB to promote inflammation and carcinogenesis by inhibiting miR‐3178 expression, which directly targeting TRAF3, during H. pylori infection in gastric mucosal epithelial cells.
Source: Helicobacter - July 31, 2016 Category: Gastroenterology Authors: Meijuan Zou, Fang Wang, Aiqin Jiang, Anliang Xia, Siya Kong, Chun Gong, Mingxia Zhu, Xin Zhou, Jun Zhu, Wei Zhu, Wenfang Cheng Tags: Original Article Source Type: research

Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ
In conclusion, DHA inhibits H. pylori‐induced STAT3 phosphorylation in a PPARγ/SOCS3‐dependent manner. This article is protected by copyright. All rights reserved
Source: Nahrung / Food - March 31, 2016 Category: Nutrition Authors: Hyeon‐Geun Ji, Juan‐Yu Piao, Su‐Jung Kim, Do‐Hee Kim, Ha‐Na Lee, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research

Helicobacter pylori induces Snail expression through ROS‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 26, 2016 Category: Molecular Biology Authors: Hoang‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research

Helicobacter pylori induces Snail expression through ROS ‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 24, 2016 Category: Molecular Biology Authors: Hoang ‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research

Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients
Chronic inflammation of gastric mucosa by Helicobacter pylori infection can initiate gastric carcinogenesis. As angiopoietin-like protein 2 (ANGPTL2) mediates inflammation and inflammation-associated carcinogenesis, we investigated the functional and clinical significance of ANGPTL2 in human gastric cancer (GC). SiRNA knockdown studies were performed for the functional assessment of ANGPTL2 in GC cell lines. ANGPTL2 expression was evaluated immunohistochemically in 192 tissue specimens from GC patients. In addition, we screened serum ANGPTL2 levels from 32 GC patients and 23 healthy controls; and validated these results in...
Source: Carcinogenesis - November 28, 2015 Category: Cancer & Oncology Authors: Toiyama, Y., Tanaka, K., Kitajima, T., Shimura, T., Imaoka, H., Mori, K., Okigami, M., Yasuda, H., Okugawa, Y., Saigusa, S., Ohi, M., Inoue, Y., Mohri, Y., Goel, A., Kusunoki, M. Tags: Original Manuscript Source Type: research

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1–p38 Activation Pathway in an HB‐EGF‐Independent Manner
ConclusionHelicobacter pylori induces internalization of EGFR via novel TAK1–p38–serine activation pathway which is independent of HB‐EGF. The interaction between TAK1 and EGFR in H. pylori‐infected cells might open new dimensions in understanding H. pylori‐associated gastric carcinogenesis.
Source: Helicobacter - February 23, 2015 Category: Gastroenterology Authors: Syed Faisal Zaidi, Alaa Refaat, Yue Zhou, Jibran Sualeh Muhammad, Myoung‐Sook Shin, Ikuo Saiki, Hiroaki Sakurai, Toshiro Sugiyama Tags: Original Article Source Type: research