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Infectious Disease: Helicobacter Pylori
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Total 31 results found since Jan 2013.
Differential H. pylori-Induced MAPK Responses Regulate Lewis Antigen Expression and Colonization Density on Gastric Epithelial Cells Between Children and Adults
In conclusion, a higher p38 expression in gastric epithelium counteracting JNK activity in children may contribute to lower Lewis antigen expression and colonization density than in adults after H. pylori infection.
Source: Frontiers in Immunology - March 8, 2022 Category: Allergy & Immunology Source Type: research
Notch Signaling Ligand Jagged1 Enhances Macrophage-Mediated Response to Helicobacter pylori
Helicobacter pylori (H. pylori) is one of the gram-negative bacteria that mainly colonize the stomach mucosa and cause many gastrointestinal diseases, such as gastritis, peptic ulcer, and gastric cancer. Macrophages play a key role in eradicating H. pylori. Recent data have shown that Notch signaling could modulate the activation and bactericidal activities of macrophages. However, the role of Notch signaling in macrophages against H. pylori remains unclear. In the present study, in the co-culture model of macrophages with H. pylori, the inhibition of Notch signaling using γ-secretase decreased the expression of inducible...
Source: Frontiers in Microbiology - July 8, 2021 Category: Microbiology Source Type: research
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR- γ and SOCS1 induction.
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction.
J Clin Biochem Nutr. 2020 Nov;67(3):248-256
Authors: Park JM, An JM, Han YM, Surh YJ, Hwang SJ, Kim SJ, Hahm KB
Abstract
The health beneficial effects of walnut plentiful of n-3 polyunsaturated fatty acid had been attributed to its anti-inflammatory and anti-oxidative properties against various clinical diseases. Since we have published Fat-1 transgenic mice overexpressing 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric pat...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research
Overexpression of Rictor protein and Rictor-H. pylori interaction impact on tumor progression and prognosis in patients with gastric cancer.
CONCLUSION: Our results demonstrate that Rictor, acting as an oncogene, might be a potential prognostic biomarker and therapeutic target in GC. We suggest that Rictor expression and H. pylori status may be a prognostic marker in gastric cancer.
PMID: 32588907 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - June 27, 2020 Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
Helicobacter Pylori Induces GATA3-Dependent Chitinase 3 Like 1 (CHI3L1) Upregulation and Contributes to Vascular Endothelial Injuries.
CONCLUSIONS H. pylori impaired vascular endothelial function. This might be due to the H. pylori-induced increased expression of GATA3, as well as the GATA3 mediated upregulated CHI3L1 and activation of the p38 MAPK pathway.
PMID: 31256192 [PubMed - in process]
Source: Medical Science Monitor - July 1, 2019 Category: Research Tags: Med Sci Monit Source Type: research
Autophagy Is a Defense Mechanism Inhibiting Invasion and Inflammation During High-Virulent Haemophilus parasuis Infection in PK-15 Cells
In this study, we sought to investigate whether SH0165 (serovar 5, high-virulent strain) and HN0001 (serovar 6, non-virulent strain) infection induces autophagy and the specific role of autophagy in bacterial invasion and inflammation during H. parasuis infection. Moreover, we explored the mechanism underlying autophagy regulated inflammation through inflammatory signaling cascades during H. parasuis infection. This observation could provide useful information for further understanding the role of autophagy in H. parasuis infection and improve our knowledge of new strategies against this pathogen.
Materials and Methods
B...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research
The effect of Helicobacter pylori on the expression of FRA-1 in gastric epithelial cells and its mechanism
Publication date: Available online 23 February 2019Source: Microbial PathogenesisAuthor(s): Yang Yang, Ke Dong, Shihe ShaoAbstractGastric cancer is a major global health threat and is often related with Helicobacter pylori (H. pylori) infection. FRA-1 is a subunit of the activator protein-1 transcription factor complex, which played a central role in cell proliferation and migration. It has also been implicated in stomach inflammation and malignancy. The present study aimed to clarify the relationship between H. pylori infection and production of FRA-1 in controlling cell proliferation and migration and its molecular mecha...
Source: Microbial Pathogenesis - February 25, 2019 Category: Infectious Diseases Source Type: research
microRNA-29a-3p, Up-Regulated in Human Gastric Cells and Tissues with < b > < i > H.Pylori < /i > < /b > Infection, Promotes the Migration of GES-1 Cells via A20-Mediated EMT Pathway
Conclusion: The miR-29a-3p may act as a tumor promotive miRNA by regulating cells migration through directly targeting of A20 gene in human gastric epithelial cells infected withH.pylori.Cell Physiol Biochem 2018;51:1250 –1263
Source: Cellular Physiology and Biochemistry - November 28, 2018 Category: Cytology Source Type: research
Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes.
Authors: Maués JHDS, Ribeiro HF, Pinto GR, Lopes LO, Lamarão LM, Pessoa CMF, Moreira-Nunes CFA, de Carvalho RM, Assumpção PP, Rey JA, Burbano RMR
Abstract
MYC is an oncogene responsible for excessive cell growth in cancer, enabling transcriptional activation of genes involved in cell cycle regulation, metabolism, and apoptosis, and is usually overexpressed in gastric cancer (GC). By using siRNA and Next-Generation Sequencing (NGS), we identified MYC-regulated differentially expressed Genes (DEGs) in three Brazilian gastric cancer cell lines representing the histological subtypes of GC (diffuse, intestinal, and ...
Source: Canadian Journal of Gastroenterology - November 11, 2018 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
The leukocyte-associated immunoglobulin (Ig) –like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in THP-1 cells after Helicobacter pylori infection
Conclusion These results together indicated that LAIR-1 modulated cell apoptosis and inflammatory cytokines secretion in THP-1 cells, which might help sustain inflammation and prevent removal of the bacteria by the immune responses.
Source: Microbial Pathogenesis - June 19, 2017 Category: Infectious Diseases Source Type: research
Autophagy Impairment by Helicobacter pylori ‐induced Methylation Silencing of MAP1LC3Av1 Promotes Gastric Carcinogenesis
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - February 17, 2017 Category: Cancer & Oncology Authors: Jibran Sualeh Muhammad, Sohachi Nanjo, Takayuki Ando, Satoshi Yamashita, Takao Maekita, Toshikazu Ushijima, Yoshiaki Tabuchi, Toshiro Sugiyama Tags: Research Article Source Type: research
Abstract A67: TFF (Trefoil Factor Family) is a novel tumor suppressor and can be the therapeutic target for pancreatic cancer
Conclusion: TFF1 and TFF2 act as tumor suppressor in pancreatic carcinogenesis in a different manner, and they can be a novel therapeutic target for PDAC.Citation Format: Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo, Masato Nagino.{Authors}. TFF (Trefoil Factor Family) is a novel tumor suppressor and can be the therapeutic target for pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2016 May 12-15; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(24 Suppl):Abstract nr A67.
Source: Cancer Research - December 13, 2016 Category: Cancer & Oncology Authors: Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo, Masato Nagino Tags: Early Detection Source Type: research
Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase {alpha}, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521 RESEARCH ARTICLE
ABSTRACT
Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. VacA exhibits pleiotropic actions in gastroduodenal disorders via its specific receptors. Recently, we found that VacA induced the phosphorylation of cellular Src kinase (Src) at Tyr418 in AZ-521 cells. Silencing of receptor protein tyrosine phosphatase (RPTP)α, a VacA receptor, reduced VacA-induced Src phosphorylation. Src is responsible for tyrosine phosphorylation of CagA at its Glu-Pro-Ile-Tyr-Ala (EPIYA) variant C (EPIYA-C) m...
Source: DMM Disease Models and Mechanisms - December 6, 2016 Category: Biomedical Science Authors: Nakano, M., Yahiro, K., Yamasaki, E., Kurazono, H., Akada, J., Yamaoka, Y., Niidome, T., Hatakeyama, M., Suzuki, H., Yamamoto, T., Moss, J., Isomoto, H., Hirayama, T. Tags: RESEARCH ARTICLE Source Type: research
MicroRNA ‐3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip‐α, by targeting TRAF3
ConclusionsTaken all together, Tip‐α might activate NF‐κB to promote inflammation and carcinogenesis by inhibiting miR‐3178 expression, which directly targeting TRAF3, during H. pylori infection in gastric mucosal epithelial cells.
Source: Helicobacter - July 31, 2016 Category: Gastroenterology Authors: Meijuan Zou, Fang Wang, Aiqin Jiang, Anliang Xia, Siya Kong, Chun Gong, Mingxia Zhu, Xin Zhou, Jun Zhu, Wei Zhu, Wenfang Cheng Tags: Original Article Source Type: research
Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ
In conclusion, DHA inhibits H. pylori‐induced STAT3 phosphorylation in a PPARγ/SOCS3‐dependent manner.
This article is protected by copyright. All rights reserved
Source: Nahrung / Food - March 31, 2016 Category: Nutrition Authors: Hyeon‐Geun Ji, Juan‐Yu Piao, Su‐Jung Kim, Do‐Hee Kim, Ha‐Na Lee, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research
