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Source: European Respiratory Journal

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Total 164 results found since Jan 2013.

Novel KLF4-FOXO1 Interactome in Lung Fibroblasts:Regulator of Myofibroblasts in Hyperoxia-Induced Lung Injury
Conclusion: Our data unveil a novel Klf4-FoxO1 axis in lung fibroblasts that could promote matrix remodeling and lung growth arrest in lungs with BPD.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Hirani, D., Koch, M., Mohr, J., Vohlen, C., Nayakanti, S., Grimm, C., Schweiger, M.-R., Georgomanolis, T., Pullamsetti, S., Dötsch, J., Alejandre Alcazar, M. A. Tags: Lung and airway developmental biology Source Type: research

LSC - 2020 - Epithelial-mesenchymal transition induced by cigarette smoke in lung epithelial cells is associated with metabolic reprogramming and senescence
A dysregulated epithelial–mesenchymal transition (EMT) contributes to tumor progression, fibrosis and lung tissue remodeling in Chronic Obstructive Pulmonary Disease (COPD). Cigarette smoke, a risk factor for all these processes, induces oxidative stress, mitochondrial damage and drives cell senescence by reducing FoxO3, an anti-aging factor. Mitochondrial dysfunction is involved in aging and increases lactate generation, which is correlated with EMT induction.Here, we investigated the cigarette smoke extract (CSE) effects on mitochondrial status and cell metabolism and on the expression of EMT markers in lung epithe...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Tags: Airway cell biology and immunopathology Source Type: research

Haploid genetic screening identifies a novel regulator of BMPR2
Pulmonary arterial hypertension (PAH), is characterised by profound remodelling of small pulmonary arteries, leading to increased pulmonary arterial pressures and premature death by right heart failure. Heterozygous germ-line mutations in the bone morphogenetic protein type II receptor (BMPR2) cause ~70% of familial PAH and ~20% of idiopathic PAH cases. The majority of mutations lead to haploinsufficiency but crucially, regardless of the presence of mutation, lung BMPR2 expression is reduced in all forms of PAH. Therefore, restoration of BMPR2 levels is an important therapeutic target. We previously showed that BMPR2 ubiqu...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Dunmore, B., Burr, S., Upton, P., Nathan, J., Morrell, N. Tags: Pulmonary hypertension Source Type: research

Protein truncating mutations in ATP13A3 promote pulmonary arterial hypertension
Conclusions: Our initial findings provide further evidence that loss of function mutations in ATP13A3 are directly involved in causation of PAH and the mechanism involves alterations in cellular polyamine levels.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Legchenko, E., Liu, B., West, J., Vangheluwe, P., Upton, P., Morrell, N. Tags: Pulmonary hypertension Source Type: research

Cbx4 Regulates RNA Binding Protein MEX-3B To Thymic stromal lymphopoietin Expression Sumoylation In Epithelium Of HDM-induced Allergic Inflammation
Conclusion: CBX4/MEX-3B/TSLP axis involved in TSLP-mediated airway inflammation,suggesting that targeting SUMO E3 ligase activity of CBX4 would be a novel target for the treatment of asthma.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: shixiu, l., Changhui, Y., Zicong, Z., Zili, Z., Jieyi, L., Shaoxi, C. Tags: Allergy and immunology Source Type: research

GCN2 regulates BMP signaling: consequence for PVOD pathobiology and therapeutic management
Conclusion: GCN2 loss-of-function negatively regulates SMAD1/5/9 phosphorylation. Despite this dampened BMP signaling, exogenous BMP9 was still able to reverse GCN2 inhibition-induced hPMEC proliferation. BMP9 may hence be considered as potential therapeutic options for PVOD
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Manaud, G., Lambert, M., Soilih, B., Girerd, B., Soubrier, F., Bignard, J., Claude, O., Lecerf, F., Florio, M., Sun, B., Nadaud, S., Verleden, S., Remy, S., Anegon, I., Mercier, O., Fadel, E., Simmoneau, G., Humbert, M., Montani, D., Antigny, F., Perros, Tags: Pulmonary hypertension Source Type: research

Regulation of Type I cytokine receptors as a target for pulmonary arterial hypertension treatment?
Conclusions: TypeIR intracellular trafficking regulation is altered in PAH patients compared to controls, due to a shift in USP8/RNF41 ratio. Restoring USP8/RNF41 ratio in PA-SMCs may represent a potential target in PAH.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Jutant, E.-M., Tu, L., Le Vely, B., Thuillet, R., Humbert, M., Guignabert, C., Huertas, A. Tags: Pulmonary hypertension Source Type: research

Role of c-Abelson in the loss of genome integrity in endothelial cells in pulmonary arterial hypertension
Conclusions: Our results demonstrate a central role of c-Abl in the loss of DNA integrity in iPAH P-ECs.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Le Vely, B., Berrebeh, N., Phan, C., Thuillet, R., Humbert, M., Huertas, A., Guignabert, C., Tu, L. Tags: Pulmonary hypertension Source Type: research

NGF induces pulmonary arterial hyperreactivity through connexin 43 increased expression
In conclusion, NGF pathway is upregulated in IPAH cells. NGF increases Cx43 PA expression through TrkA receptor. Cx43 increased expression at plasma membrane upregulates GAP junction activity, thus promoting PA hyperreactivity.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Cardouat, g., Douard, M., Roubenne, L., Kmecova, Z., Robillard, P., Guignabert, C., Tu, L., Delcambre, F., Marthan, R., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research

Inhibition of the Arp2/3 complex inhibits lung myofibroblast differentiation in vitro and attenuates bleomycin-induced pulmonary fibrosis in mice
Conclusion: Increased expression of Arp2/3 was observed both in IPF fibroblasts and in bleomycin-exposed mouse lungs. CK666 and siARPC2 attenuated profibrotic differentiation of lung fibroblasts. CK666 attenuated bleomycin-induced lung fibrosis in vivo. Arp2/3 Inhibition may be an attractive new therapy for IPF and other fibrotic interstitial lung diseases.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Mergault, C., Lisee, F., Tiroille, V., Heuze-VourcH, N., Parent, C., Sizaret, D., Marchand-Adam, S., Plantier, L. Tags: Mechanisms of lung injury and repair Source Type: research

Late Breaking Abstract - The effects of BMPRII loss on endothelial shear adaptation in the pulmonary vascular endothelium
Conclusion: Reduced BMPRII expression may contribute to PAH by engendering abnormal pulmonary artery endothelial shear adaptation.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Mahomed, A., Burke-Gaffney, A., Moledina, S., Wort, S. J. Tags: Pulmonary hypertension Source Type: research

Cigarette Smoke Extract Promotes Human Lung Myofibroblast Differentiation by the Induction of Endoplasmic Reticulum Stress
Conclusion: Our data suggested that CSE promotes lung fibroblast-to-myofibroblast differentiation by the induction of ER stress.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Song, M., Peng, H., Guo, W., Luo, M., Duan, W., Chen, P., Zhou, Y. Tags: Idiopathic interstitial pneumonias Source Type: research

Lysosomal dysfunction in COPD pathogenesis
Conclusion: These findings suggest that accumulation of dysfunctional lysosome, which is attributed to reduced TRIM16-mediated lysophagy, can be associated with enhanced epithelial cell damage during COPD pathogenesis.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Saito, N., Araya, J., Ito, A., Hosaka, Y., Ichikawa, A., Kadota, T., Nakano, T., Yoshida, M., Fujita, Y., Utsumi, H., Hashimoto, M., Wakui, H., Minagawa, S., Hara, H., Numata, T., Kaneko, Y., Kuwano, K. Tags: Airway cell biology and immunopathology Source Type: research

Cigarette smoke decreases E-Cadherin expression downregulating FoxO3 in lung epithelial cells
Epithelial to mesenchymal transition (EMT) is implicated in lung tissue remodeling in Chronic Obstructive Pulmonary Disease (COPD). EMT is characterized by loss of epithelial junctions, including down-regulation of E-cadherin. Several signaling pathways are implicated in EMT, including TGF-β. TGF-β stimulation causes SMAD-independent activation of AKT resulting in phosphorylation and subsequent degradation of forkhead box class O3 (FoxO3). FoxO3 prevents the transcription activity of β-catenin, which controls expression of SNAIL1 and ZEB1, repressors of E-cadherin gene expression. The FoxO3 expression is red...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Di Vincenzo, S., Sangiorgi, C., Ferraro, M., Gjomarkaj, M., Ninaber, D. K., Hiemstra, P. S., Pace, E. Tags: Airway cell biology and immunopathology Source Type: research

Follistatin-like 1 promotes intermittent hypoxia-induced lung fibroblast activation in vitro and in vivo
Conclusion: Intermittent hypoxia can induce oxidative stress, which in turn leads to fibroblast activation, and this effect may be related to the expression of FSTL1 protein.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Xu, L., Cao, J. Tags: ILD/DPLD of known origin Source Type: research