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Source: European Respiratory Journal

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Total 164 results found since Jan 2013.

Extracellular vesicles (EVs) as diagnostic tools in the phenotypic determination of lung tumors
Immunotherapy has been one of the great advances in recent years for the treatment of advanced tumors. Our goal is to determine whether extracellular vesicles (EVs) are effective and appropriate tools for detecting and blocking immune checkpoints proteins (ICPs). We developed a method for tracing tumor content via an analysis of EVs surface makers in the bloodstream using the MAGPIX platform (Fig.1). As a proof of concept, we have developed the detection of 4 ICP-EV. We will use this technology to monitor the ICP-EV profile in patients undergoing immunotherapeutic treatment. Second, endothelial EVs will be used as drug car...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Cambier, M., Muller, F., Henket, M., Remacle, C., Guiot, J., Struman, I. Tags: 11.01 - Lung cancer Source Type: research

Inhibitory role of retinoic acid-related orphan receptor alpha RORa in human lung fibroblast activation.
We examined the role of RORα in human lung fibroblasts (HLF) from controls (n=4) and IPF (n=5). siRNA knockdown of RORα resulted in a significant upregulation of aSMA protein in IPF and control HLFs. Treatment with RORa antagonist R1001 revealed a trend of upregulation of aSMA mRNA, while, an opposite trend was observed with RORa agonist, R1078 in IPF and control HLFs. Furthermore, the induction of aSMA levels in IPF HLFs treated with R1001 was significantly higher compared to treated control HLFs. Next, the effect of TGFb1 treatment on RORa expression was evaluated. Importantly, a significant downregulati...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Zevla, D. M., Tsitoura, E., Crestani, B., Antoniou, K. Tags: 12.01 - Idiopathic interstitial pneumonias Source Type: research

MiR-125b-5p up-regulation in asthma and COPD overlap patients mediates oxidative stress and apoptosis via targeting IL6R/NLRC5/TRIAP1
Conclusions: MiR-125b-5p is up-regulated in ACO patients, and may cause oxidative stress and cell apoptosis through targeting IL6R, NLRC5, TRIAP1 genes.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Chang, Y., Lee, C., Chen, Y. Tags: 03.01 - Molecular pathology and functional genomics Source Type: research

IL-11 increases levels and activates circulating fibrocytes in different pulmonary hypertension animal models.
In conclusion, IL-11 promotes an increase of circulating fibrocytes, their adhesion to HPAECs and phenotypic switching to myofibroblast.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Roger, I., Milara, J., Montero, P., Belhadj, N., Cortijo, J. Tags: 13.01 - Pulmonary hypertension Source Type: research

Identify Bcl3 as a novel biomarker shared between severe asthma and lung cancer using next-generation RNA sequencing from archival FFPE tissue biopsies
Conclusion: Our findings indicate a Bcl3 a novel putative biomarker in pathogeneses of both severe asthma and lung cancer.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Salameh, L., Manasa Bhamidimarri, P., Elemam, N., Ali, N., Dairi, Y., Alsharhan, M., Tirmazy, S. H., Hamid, Q., Mahboub, B., Al Heialy, S., Hamoudi, R. Tags: 03.03 - Mechanisms of lung injury and repair Source Type: research

Investigating the effects of metals within particulate matter in human alveolar epithelial cells
Conclusion: These novel data show the ability of metals present in PM to modulate a range of signalling pathways to elicit differential cellular responses and activate several potentially pathological mechanisms. Future work will further explore these mechanisms.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Dean, L. S., Vethakan-Raj, H. S., Parkin, J. G., Ridley, R. A., Conforti, F., Downward, J., Wang, Y., Jones, M. G., Davies, D. E., Loxham, M. Tags: 03.02 - Airway cell biology and immunopathology Source Type: research

Screening and verification of differentially expressed genes for airway remodeling in asthma
Conclusion: The expression of CTSK may related to the airway remodeling of asthma by up-regulating the TGF-β1 expression in BECs.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Qin, L., Liu, C., Wu, M., Yao, Y. Tags: 05.03 - Allergy and immunology Source Type: research

Exogenous HSP70 regulates the expression of glucocorticoid receptor in a cell type-specific manner
Conclusion: Exogenous HSP70 increases the expression of GR in EC in a cell type-specific manner. Such effect suggests that EC have an increased sensitivity towards steroids. As EC require cortisol for their recovery from stress, for proliferation, and for differentiation, these data could explain the fast recovery of the epithelium after thermoplasty, as well as the clinically observed reduced need of steroids after thermoplasty.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Zhou, L., Fang, L., Tamm, M., Roth, M., Stolz, D. Tags: 05.01 - Airway pharmacology and treatment Source Type: research

Silencing MMP7 expression with a lung-targeted RNAi molecule limits fibrosis and preserves pulmonary function in bleomycin-injured rats
Conclusions: Integrin targeting ligand-conjugated siRNAs potently silence MMP7 expression, limit fibrosis and improve lung function in the rat bleomycin model. ARO-MMP7 is a promising new therapeutic candidate for the treatment of IPF.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Yuan, T., Nicholas, A., Lakomski, N., Afrazi, M., Hamilton, H., Hegge, J., Hamilton, J., Pei, T., Bush, E. Tags: 12.01 - Idiopathic interstitial pneumonias Source Type: research

Role of urokinase-type plasminogen activator receptor (uPAR) in senescent lung cells
Conclusion: uPAR is highly expressed in lung fibroblasts but not increased in senescence. In SAEC, uPAR may be elevated in senescence but does not correlate with the senescence markers examined. This suggests that uPAR is unlikely to be a useful target for senescent lung cell removal.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Wrench, C., Dodgson, J., Overed-Sayer, C., Donnelly, L., Barnes, P. Tags: 03.02 - Airway cell biology and immunopathology Source Type: research

COX2 expression is downregulated in a shear stress magnitude-dependent manner in BMPR2-silenced HPAECs: implications for prostacyclin deficiency in PAH
Conclusion: BMPR2 loss may disrupt the flow-driven production of COX2 in HPAECs, which may be an underlying mechanism of endothelial dysfunction in PAH.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mahomed, A., Burke-Gaffney, A., Ghazaly, M., Naser, J., Toe, Q., Quinlan, G., Wort, S. J. Tags: 13.01 - Pulmonary hypertension Source Type: research

Prolyl-3-hydroxylase 4 (P3H4), a novel player in collagen synthesis and secretion in lung fibroblasts
In conclusion, P3H4 and FKBP10 reciprocally regulate each other in lung fibroblasts, and P3H4 represents a novel modulator of collagen biosynthesis in the lung and hence a potential therapeutic target for IPF.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Onursal, C., Knüppel, L., Lietman, C. D., Merl-Pham, J., Hatz, R., Behr, J., Unger, K., Hess, J., Hauck, S. M., Lee, B., Staab-Weijnitz, C. Tags: 12.01 - Idiopathic interstitial pneumonias Source Type: research

Novel strategies for genetic manipulation of human iPSC-derived organoid platforms
Conclusions: Our preliminary data demonstrates modest but successful transfection of patient iPSC-derived organoid cultures ‘in situ’ in 3D matrigel using a commercial transfection reagent. Further development of these methods will facilitate miRNA:Target gene interaction studies to complement ongoing research in iPSC organoid platforms and inform delivery of future therapeutic strategies utilising small RNA.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Oglesby, I., De Santi, C., Schweikert, A., Cryan, S. A., Hurley, K. Tags: 03.02 - Airway cell biology and immunopathology Source Type: research

Role of Connexin 43 increased expression in pulmonary arterial hyperreactivityinduced by the nerve growth factor NGF
In conclusion, NGF pathway is upregulated in IPAH cells. NGF increases Cx43 PA expression through activation of its TrkA receptor. NGF-induced Cx43 increased expression upregulates GAP junction activity, thus promoting PA hyperreactivity.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Cardouat, g., Douard, M., Roubenne, L., Bouchet, C., Kmecova, Z., Robillard, P., Guignabert, C., Tu, L., Delcambre, F., Marthan, R., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research

Late Breaking Abstract - Involvement of Orai1 Ca2+ channel in the pathogenesis of pulmonary arterial hypertension. Orai1 as a new potential therapeutic target ?
Conclusion: Altogether our results provide proof of concept that Orai1 should be considered as a new therapeutic target in PAH.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Masson, B., Le Ribeuz, H., Sabourin, J., Woodhouse, E., Foster, R., Ruchon, Y., Dutheil, M., Boët, A., Ghigna, M.-R., Mercier, O., Beech, D., Benitah, J.-P., Bailey, M., Humbert, M., Montani, D., Capuano, V., Antigny, F. Tags: Pulmonary hypertension Source Type: research