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Source: European Respiratory Journal

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Total 164 results found since Jan 2013.

MUC4 overexpression correlates corticoid resistance in chronic rhinosinusitis with nasal polyps
Conclusion: MUC4 participates in the corticoid response that mediates GRα nuclear translocation. The high expression of MUC4 in patients with CRSwNP may participate in corticoid resistance.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Contreras, S., Serrano, A., Diaz, L., Ballester, B., Banuls, P., Milara, J., Morell, A. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Expression and function of aquaporin 1 in hypoxia-induced pulmonary hypertension
Conclusion: Hx modulates the expression of Aqp1 in vivo and in vitro. Inhibition of Aqp1 through siRNA resulted in less migration and more apoptosis. These data suggest an important functional role of Aqp1 in the development of hypoxia-induced PH.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Schuoler, C., Haider, T., Leuenberger, C., Gassmann, M., Kohler, M., Huber, L., Brock, M. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells
In this study, we determined whether autophagy could be induced by pemetrexed and simvastatin cotreatment in malignant mesothelioma and NSCLC cells. Furthermore, we determined whether inhibition of autophagy drives apoptosis in malignant mesothelioma and NSCLC cells. Malignant mesothelioma MSTO-211H and A549 NSCLC cells were treated with pemetrexed and simvastatin alone and in combination to evaluate their effect on autophagy and apoptosis. Cotreatment with pemetrexed and simvastatin induced greater caspase-dependent apoptosis and autophagy than either drug alone in malignant mesothelioma and NSCLC cells. 3-Methyladenine (...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kim, H.-R., Cho, K.-H., Hwang, K.-E., Jeong, E.-T. Tags: 11.1 Lung Cancer Source Type: research

LATE-BREAKING ABSTRACT: Inhibition of the ubiquitin-E3-ligase FBXW7 enhances steroid efficacy: New concept for treating steroid insensitivity
Conclusion: Reduction of FBXW7 caused a significant augmentation of functional GR and may have the potential to improve the efficacy of steroids.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kaestle, M., Wyatt, D., Nicklin, P. Tags: 5.3 Allergy and Immunology Source Type: research

LSC Abstract - Toll-like receptor 10: Expression and functional role in LPS mediated inflammation
We examined TLR10 expression in normal and inflamed lungs from chickens and humans. Immunohistochemistry showed TLR10 in vascular endothelium in human and chicken lungs. Immunohistochemistry and Western blots showed an increase in TLR10 protein in lungs of chicken infected with E. coli or Fowl Adenovirus. Human neutrophils challenged with E. coli lipopolysaccharide (LPS) showed decreased total TLR10 protein and surface expression in 90 minutes. Confocal microscopy showed cytosolic and nuclear distribution of TLR10 in normal neutrophils. In the LPS-activated neutrophils, TLR10 colocalized with flotallin-1, a lipid raft mark...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Balachandran, Y., Singh, B. Tags: 3.1 Molecular Pathology and Functional Genomics Source Type: research

Glycerol kinase 5 regulates wound healing of airway epithelial cells by mediating aquaglyceroporin 3 and 9
Epithelial cells serve as a physical barrier to protect the underlying tissue, while wound healing of airway epithelial cells is critical to maintain the barrier function.Glycerol kinase 5 (GK5) , an enzyme catalyzing the phosphorylation of glycerol, plays an important role in glycerol metabolism; however, the role of GK5 in the wound healing of airway epithelial cells is not clear.In our study, immunohistochemistry was used to examine the protein expression of GK5 in different cell types in rat airways. RT-PCR and western blot were applied to measure the gene and protein expression of GK5 and aquaglyceroporins (AQP3 and A...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Zhou, J., Bai, C. Tags: 3.3 Mechanisms of Lung Injury and Repair Source Type: research

Mucin 1 downregulation associates with corticoid resistance in chronic obstructive pulmonary disease and chronic rhinosinusitis with nasal polyps
Conclusion: Corticoid response that mediates GRα nuclear translocation requires MUC1-CT. The low expression of MUC1 in patients with CRSwNP or COPD may participate in corticoid resistance.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Morell, A., Milara, J., Diaz, L., Ballester, B., Peiro, T., Gonzalez, S., Banuls, P., Cortijo, J. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells
Conclusion: In conclusion, increased VEGF-A produced by MSC can account for the increased vessel formation observed during treprostinil treatment. Moreover, our results suggest that VEGF-A level in patients could be a surrogate biomarker of treprostinil efficacy.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Smadja, D., Levy, M., Huang, L., Rossi, E., Israel-Biet, D., Gaussem, P., Bischoff, J. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

INTS12 knockdown leads to perturbation of genes and pathways of relevance to airway biology
Conclusions: INTS12 regulates pathways important in lung function through perturbation of genes belonging to e.g. collagen formation pathway. INTS12 is likely to control protein synthesis through effects on tRNA aminoacylation pathway.Funding: Medical Research Council.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kheirallah, A. K., Sayers, I., Hall, I. Tags: 3.1 Molecular Pathology and Functional Genomics Source Type: research

Airway epithelial cell IP-10 production is regulated by miR-31 via the transcription factor IRF-1
In this study, we evaluated IP-10 levels in CF pulmonary epithelial cells and found that IP-10 expression and production were significantly increased in CF tracheal and bronchial epithelial cell lines compared to non-CF controls. The transcription factor IRF-1 has been reported to play a role in the regulation of IP-10 and our recent work has shown that IRF-1 levels are increased in CF pulmonary epithelial cells via dysregulation of the miRNA, miR-31. Knock-down of IRF-1 using siRNA significantly decreased expression and secretion of IP-10 from CF bronchial epithelial cells. In agreement with previous work, overexpression ...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kerrigan, L., Taggart, C., Weldon, S. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Olfactory receptors in pulmonary arterial hypertension: A novel pathway of vascular remodeling?
Pulmonary arterial hypertension (PAH) is due to progressive obstruction of pulmonary arteries, thus leading to right heart failure and death. Breath volatile organic compounds (VOCs) can discriminate PAH and controls. Thus, a unique breath-print of PAH is detected using an artificial nose. VOCs target olfactory receptors (ORs) in olfaction. Interestingly, ORs are detected in peripheral tissues not related to olfaction and their deregulation is associated to cancer development. PSGR, encoded by the OR51E2 gene, is one of the ORs. Because vascular cells in PAH exhibit properties of cancer cells, we propose the ground-breakin...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Courboulin, A., Sanz, G., Breuils-Bonnet, S., Quatredeniers, M., Vocelle, M., Lafond, M., Perros, F., Bonnet, S., Pajot-Augy, E., Humbert, M., Cohen-Kaminsky, S. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Nuclear IL-33 arguments ST2 receptor expression in pulmonary arterial endothelial cells: Implication in the pathogenesis and progression of pulmonary arterial hypertension
Conclusion: IL-33 regulates the expression of IL-6 and sST2, an endogenous IL-33 inhibitor, and may play an important role in the pathogenesis of PAH.Funded by:The Doverdale Trust, Royal Brompton Hospital, London, UK.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Shao, D., Perros, F., Meng, C., Caramori, G., Humbert, M., Chou, P.-C., Adcock, I., Wort, S. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Role of class IIa histone deacetylases in the pathogenesis of pulmonary hypertension
Conclusions: Our findings suggest that classIIa HDACs are involved in PH pathogenesis and their specific inhibition may represent a therapeutic target.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Gamen, E., Grimminger, F., Seeger, W., Savai Pullamsetti, S. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Mitophagic regulation of myofibroblast differentiation in lung fibroblasts
Conclusion:These findings suggest insufficient mitophagy-induced ROS production with subsequent PDGFR-PI3K-Akt activation is a potent underlying mechanism for myofibroblast differentiation in the pathogenic sequence of fibrotic lung disorders.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Kobayashi, K., Araya, J., Hara, H., Kurita, Y., Ito, S., Takasaka, N., Fujii, S., Minagawa, S., Kojima, J., Numata, T., Shimizu, K., Kawaishi, M., Kaneko, Y., Morikawa, T., Nakayama, K., Kuwano, K. Tags: 3.1 Molecular Pathology and Functional Genomics Source Type: research

The effects of INTS12 knockdown on processing of snRNAs
Conclusions: INTS12 is likely to play an important role in HBEC function via snRNA processing: this may affect transcription globally.Funding: Medical Research Council1. Baillat et al. (2005) Cell 123 (2): 265–76.2. Obeidat et al. (2013) PLoSOne 18;8(9): e74630.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Kheirallah, A. K., Hodge, E., Nelson, C., Sayers, I., Hall, I. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research