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Source: European Respiratory Journal
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Total 164 results found since Jan 2013.
Late Breaking Abstract - NGF induces pulmonary arterial hyperreactivity through increased connexin-43 expression: potential role in pulmonary hypertension
Conclusions: Our results show that NGF increases Cx43 expression in human and rat PA through a TrkA/PI3K/ERK-dependent signalling pathway. This mechanism contributes to NGF-induced PA hyperreactivity and may thus participate in PH pathophysiology.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Douard, M., Robillard, P., Deweirdt, J., Baudrimont, I., Dubois, M., Marthan, R., Savineau, J.-P., Muller, B., Guibert, C., Freund-Michel, V. Tags: Pulmonary hypertension Source Type: research
Late Breaking Abstract - Chronic Hypoxia Promotes Pulmonary Venous Smooth Muscle Cells Proliferation by Upregulating Calcium Sensing Receptor
Conclusions: CaSR mediating excessive PVSMC proliferation is a new pathogenic mechanism involved in the initiation and progression of hypoxic PVSMC proliferation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Peng, G., Li, S., Hong, W., Xu, J., Liu, R., Li, B., Ran, P. Tags: Pulmonary hypertension Source Type: research
FKBP10 regulates fibroblast migration via synthesis of collagen VI
Conclusion: FKBP10 deficiency in phLF attenuates migration mainly by decreased synthesis of collagen VI.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Knüppel, L., Heinzelmann, K., Lindner, M., Hatz, R., Behr, J., Eickelberg, O., Staab-Weijnitz, C. Tags: Mechanisms of Lung Injury and Repair Source Type: research
Cigarette smoke induces mitochondrial dysfunction via PKCd-p66Shc signaling pathway in human bronchial epithelial cells
Conclusions: These data suggest that PKC-p66Shc pathway may be involved in the pathogenesis of COPD.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Zhang, M., Li, Y., Tang, J., Zhang, J., Yang, X., Shan, H., Zhang, Q. Tags: Airway Cell Biology and Immunopathology Source Type: research
Role of MUC4 in idiopathic pulmonary fibrosis
Conclusions: MUC4 expression is increased in IPF lungs and collaborates with TGFβ1 to induce EMT and FMT cellular transformations. Pharmacologic targeting of MUC4 may be a promising option for the treatment of IPF.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Ballester, B., Milara, J., Guijarro, R., Morcillo, E., Cortijo, J. Tags: Idiopathic interstitial pneumonias Source Type: research
Andrographolide inhibits the activation of NLRP3 inflammasome in patients with COPD
Conclusion: Natural product andrographolide inhibited the NLRP3 inflammasome activation in COPD and might be a potential strategy to target COPD excerbations.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Xiao, W., Fu, J.-J., Wang, S.-J., Wang, Y., Miao, T.-W., Mao, B. Tags: Airway pharmacology and treatment Source Type: research
Role of microtubule-associated signaling in Staphylococcus aureus-induced lung injury.
This study tested the role of microtubules (MT) in the mechanisms of SA-induced ALI. EC dysfunction was accompanied by decrease in acetylated tubulin, MT destabilization, and increased activity of histone deacetylase-6 (HDAC6) as a result of oxidative stress. HDAC6 inhibition using gene-specific siRNA or tubastatin A rescued SA-induced EC barrier disruption monitored by measurements of electrical resistance and macromolecular permeability. SA-induced EC dysfunction was associated with impaired MT-mediated delivery of cytoplasmic linker-associated protein 2 to the cell periphery limiting its interaction with adherens juncti...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Birukova, A., Karki, P., Tian, Y., Sarich, N., Ke, Y., Birukov, K. Tags: Mechanisms of Lung Injury and Repair Source Type: research
Promotion of pulmonary fibroblast migration by bile acid receptor through activation of TGF-ss1/p-Smad3 signaling pathway
Conclusion: GPBAR1 could promote the migration of pulmonary fibroblasts through activation of TGF-β1/p-Smad3 signaling pathway.(Sponsored by Natural science Foundation of China(91629104))
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Liu, X., Wang, F. F., Jiang, H. Tags: Idiopathic interstitial pneumonias Source Type: research
Dysregulated mitochondrial integrity associated with lamin B1 reduction is involved in cellular senescence progression in COPD pathogenesis
Conclusion: These findings suggest the involvement of mTOR-mediated dysregulated mitochondrial integrity in cellular senescence progression during lamin B1 reduction in COPD pathogenesis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Saito, N., Araya, J., Ito, S., Hosaka, Y., Kadota, T., Yoshida, M., Tsubouchi, K., Ichikawa, A., Kurita, Y., Kobayashi, K., Minagawa, S., Hara, H., Utsumi, H., Yanagisawa, H., Hashimoto, M., Wakui, H., Ishikawa, T., Numata, T., Kaneko, Y., Nakayama, K., K Tags: Airway Cell Biology and Immunopathology Source Type: research
Increased CTGF expression of circulating fibrocytes in asthmatic patients with severe OSA - the role of HIF-1a and HDAC7
Conclusion: Severe OSA related hypoxia increases CTGF expression in circulating fibrocytes via activation of HIF-1α that requires HDAC7 nuclear co-transprotation. HDAC7 may serve a therapeutic target for airway remodeling in asthmatics with severe OSA.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wang, T.-Y., Lo, Y.-L., Wang, C.-H., Kuo, H.-P. Tags: Airway Cell Biology and Immunopathology Source Type: research
Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis
Conclusion: Intact MKP5 is required for induction of changes in lung fibroblasts in-vitro and during bleomycin-induced lung fibrosis in-vivo. MKP5 inhibition represent a promising therapeutic target for experimental and lung fibrosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tzouvelekis, A., Karampitsakos, T., Min, K., Xylourgidis, N., Yu, G., Herazo-Maya, J., Bizenhofer, L., Bennett, A., Kaminski, N. Tags: Idiopathic interstitial pneumonias Source Type: research
Krüppel-like factor 4 (Klf4) is a novel regulator of neonatal lung fibroblast homeostasis and reduced in hyperoxia-induced lung injury
Conclusion: We identify Klf4 as a novel key regulator of neonatal lung fibroblast homeostasis. Loss of Klf4 is intimately linked to myofibroblast activation, fibrosis and migration, eventually reducing thereby alveolar formation and contributing to the pathogeneis of BPD.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Hirani, D., Koch, M., Dinger, K., Mohr, J., Vohlen, C., Klaudt, C., Dötsch, J., Alejandre Alcazar, M. A. Tags: Lung and airway developmental biology Source Type: research
Role of TREM1-Ripk3 axis in hyperoxia induced lung injury in neonates.
Hyperoxia-induced lung injury (HALI) is one of the major contributor to the development of bronchopulmonary dysplasia (BPD), a devastating lung disease in premature infants, the mechanisms of which are not fully characterized. Here we report that the triggering receptor expressed on myeloid cells 1 (TREM-1) is upregulated in hyperoxia exposed neonatal mice lungs as well as in human neonatal lungs with respiratory distress syndrome (RDS) and BPD as an adaptive response to survive hyperoxia. Inhibition of TREM-1 function using siRNA approach or deletion of TREM-1 gene in mice showed increased alveolar damage and mortality of...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Syed, M. A., Shah, D., Bhandari, V. Tags: Lung and airway developmental biology Source Type: research
Analyzing the role of proteasome activator 200 (PA200) in lung cancer
The proteasome system is the main cellular protein degradation machinery and acts as a key regulator of cellular growth, survival and signaling. Tumor cells are highly dependent on its function and the proteasome has been shown to be activated in colon or breast cancer. Its regulation in lung cancer, however, is largely unknown. We here investigated the role of the proteasome activator PA200 in lung cancer to determine its so far unknown regulation in disease and to better characterize proteasome regulation in lung cancer.The specificity of PA200 antibodies was first validated by siRNA-mediated silencing of PA200 in A549 a...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Welk, V., Meul, T., Lukas, C., Bölükbas, D., Koch, I., Lindner, M., Meiners, S. Tags: Lung Cancer Source Type: research
The BRD4-PLK1 Axis Drives Vascular Remodeling in PAH
Conclusion: We demonstrate that the BRD4/PLK1 axis is increased in human PAH and represents a promising therapeutic target.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Boucherat, O., Tremblay, E., Martineau, S., Jahagirdar, R., Kulikowski, E., Provencher, S., Bonnet, S. Tags: Pulmonary hypertension Source Type: research
