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Source: European Respiratory Journal
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Total 164 results found since Jan 2013.
Reactive sulfur species are involved in cigarette smoke-induced cellular senescence
Conclusions: The current study suggests that the reduction in reactive sulfer species might be related to CS-induced cellular senescence.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Yamanaka, S., Ichikawa, T., Sugiura, H., Numakura, T., Sano, H., Yamada, M., Fujino, N., Tanaka, R., Kyogoku, Y., Akaike, T., Ichinose, M. Tags: Molecular pathology and funct. genomics Source Type: research
Human airway trypsin-like protease stimulates protease activated receptors and interactions of these receptors
Conclusions: These results indicate that HAT may attack and activate PAR1, PAR2 and PAR3 in HBECs. These PARs, particularly PAR2 and PAR3, are intimately associated with IL-8 synthesis in HBECs, by mutual interrelations.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Miki, M., Yasuoka, S., Tsutsumi, R., Takeuchi, Y., Miki, K., Kitada, S. Tags: Airway cell biology and immunopathology Source Type: research
Comparison of anticancer effects of a novel histone deacetylase (HDAC) inhibitor CG200745 and SAHA in non-small lung cancer cells
Histone deacetylase (HDAC) inhibition offers the potential for anti-cancer effects in a variety of cancers, since HDAC plays an important role in cancer development and progression. Thus, we demonstrated the therapeutic efficacy of the new HDAC inhibitor, CG200745, in comparison with existing HDAC inhibitors, such as suberoylanilide hydroxamic acid (SAHA) in non-small lung cancer cells.Compared with SAHA, CG200745 had inhibited cell viability and HDACs expression, and induced apoptosis, ROS and mitochondrial dysfunction. CG200745 also significantly reduced tumor volume in vivo compared with SAHA. We observed increased apop...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Kim, H.-R., Jung, J.-W., Hwang, K.-E., Park, C., Jeong, E.-T. Tags: Lung cancer Source Type: research
Downregulation of lysosome-associated membrane protein-2A accelerates cigarette smoke extract-induced aging and apoptosis in human bronchial epithelial cells
In this study, we evaluated the expression level of LAMP-2A in lung tissues and primary human bronchial epithelial cells (HBEC) of the normal, smoker, and COPD patients and investigated the role of LAMP-2A in cigarette smoke extract (CSE)-induced aging and death in lung epithelial cells (BEAS-2B). The protein level of LAMP-2A significantly decreased in lung homogenates from smokers and COPD patients compared with never smokers. Immunohistochemical analysis showed a significant decrease of LAMP-2A level in lung epithelial cells. Primary HBEC from smokers and COPD patients expressed a lower level of LAMP-2A than never smoker...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Lee, K.-H., Jeong, Y., Kim, J. Y., Lee, C.-H., Yoo, C.-G. Tags: Mechanisms of lung injury and repair Source Type: research
Hippo Effector YAP regulates Autophagy key effector p62 in Lung Adenocarcinoma
Conclusion: Taken together, our findings uncover a significant regulatory axis for autophagic key factor p62 by Hippo effector YAP in EGFR-TKI resistant lung adenocarcinoma. Targeting the autophagy by YAP could provide an effective therapeutic strategy for intractable lung cancer such as EGFR-TKI-resistant lung adenocarcinoma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chung, C., Kim, J. O., Park, D. I., Lee, D., Lee, J. E., Park, H. S., Kang, D. H., Kim, Y. Tags: Lung cancer Source Type: research
Role of MUC4 in idiopathic pulmonary fibrosis
Conclusions: MUC4 collaborates with pSmad2/3 and pTGFβRI inducing IPF progression. Therefore, pharmacologic targeting of MUC4 may be a potential target to design new therapies for IPF.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Ballester Llobell, B., Milara Paya, J., Montero Magallo, P., Roger Laparra, I., Estornut Navarro, C., Cortijo Gimeno, J. Tags: Idiopathic interstitial pneumonias Source Type: research
The Hippo pathway effectors TAZ and YAP are sequentially required in lung development
Conclusion: Our results indicate that TAZ and YAP function at different stages of lung development in lung epithelial cells and essential for proper lung development. Our results suggested the existence of a novel pathway between TGF-beta and Shh.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Isago, H., Mitani, A., Kohno, S., Nagoshi, H., Ishimori, T., Saito, M., Tamiya, H., Mikami, Y., Horie, M., Urushiyama, H., Jo, T., Tanaka, G., Hamamoto, R., Terasaki, Y., Nagase, T. Tags: Lung and airway developmental biology Source Type: research
LSC - 2019 - RNA degradation is a deficient antiviral mechanism in the asthmatic airway epithelium
Conclusions: Our data suggest that decreased UPF1 levels in asthma BECs contribute to impaired antiviral immunity and RV-induced exacerbations in asthma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wong, T., Rynne, J., Howarth, P. H., Edwards, M. R., Martinez-Nunez, R. T. Tags: Respiratory infections Source Type: research
NF-kB activation in cystic fibrosis: The dream of A20
In conclusion, high expression of the repressor DREAM inhibits A20 transcription in CF epithelial cells. Our work suggests an important role of the A20-DREAM axis in (innate) inflammation, providing a new molecular target for the development of innovative anti-inflammatory therapies.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Momtazi, G., Elbanna, A., Finnegan, S., Heritier, M., Lavery, L., Mccollum, K., Naranjo, J., Schock, B. Tags: Airway cell biology and immunopathology Source Type: research
The RNA binding protein HuR regulates the senescence-associated secretory phenotype under conditions of oxidative stress
Conclusion: Gene silencing of HuR in the presence and absence of oxidative stress results in increased expression of inflammatory mediators, MMPs and senescence markers, suggesting HuR may play a role in regulation of the SASP in COPD.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Hassibi, S., Baker, J., Donnelly, L., Barnes, P. Tags: Airway cell biology and immunopathology Source Type: research
Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis
Conclusion: These findings suggest that reduced CMA activity may be involved in the mechanism for epithelial cell apoptosis by enhancing CS-induced UPR in COPD pathogenesis.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Hosaka, Y., Araya, J., Fujita, Y., Tsubouchi, K., Minagawa, S., Hara, H., Nakano, T., Ito, A., Ichikawa, A., Saito, N., Kadota, T., Yoshida, M., Hashimoto, M., Numata, T., Kaneko, Y., Kuwano, K. Tags: Airway cell biology and immunopathology Source Type: research
Hypoxia-inducible factor pathway activation promotes bone-type collagen cross-linking in Idiopathic Pulmonary Fibrosis
Conclusions: Our results suggest that HIF pathway activation via LH2/LOXL2 may be a core regulator of bone-type collagen fibrillogenesis in IPF.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Brereton, C. J., Yao, L., Bell, J., Conforti, F., Alzetani, A., Fabre, A., Marshall, B. G., Richeldi, L., Davies, D. E., Wang, Y., Jones, M. G. Tags: Mechanisms of lung injury and repair Source Type: research
Investigating the role of AKAP13 on epithelial cell TGFss activation
Conclusion: AKAP13 expression is found predominantly in epithelial cells in the lung. AKAP13 appears to regulate RhoA activation in iHBECs and influence αvβ6 expression. This suggests that it is involved in the RhoA-αvβ6 pathway that drives TGF-β activation in epithelial cells.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Organ, L., Porte, J., John, A., Jenkins, G. Tags: Mechanisms of lung injury and repair Source Type: research
Alternative Polyadenylation(APA) modulates extracellular matrix deposition in pulmonary hypertension
Cleavage and polyadenylation is an important and regulated step in the maturation of mRNAs. Alternative polyadenylation (APA) is typically a shortening of the 3’UTR of affected gene by using a second polyadenylation signal. This shortening can remove regulation and can lead to increased expression of these mRNAs. APA induced by the depletion of the 25kDa subunit of cleavage factor I (CFIm25) has been shown to affect transcripts encoding for extracellular matrix (ECM) Proteins. This leads to the hypothesis that APA due to reduced CFIm25 expression could play a role in modulating ECM production of pulmonary vasculature...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Collum, S., Weng, T., Hernandez, A., Mertens, T., Chen, N., Guha, A., Youker, K., Wagner, E., Han, L., Blackburn, M., Karmouty-Quintana, H. Tags: Pulmonary Hypertension Source Type: research
Cigarette smoke exposure decreases CFLAR expression in bronchial epithelium, augmenting susceptibility for cell death and DAMP release
In conclusion, CS exposure decreases CFLAR expression, which might increase susceptibility to immunogenic cell death. Our study suggests that susceptibility for CS-induced airway inflammation is driven by dysregulated cell death machinery, which may be used at target for future COPD treatments.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Pouwels, S. D., Faiz, A., Heijink, I. H., Vermeulen, C. J., Guryev, V., Van Den Berge, M., Nawijn, M. C. Tags: Mechanisms of Lung Injury and Repair Source Type: research
