Human airway trypsin-like protease stimulates protease activated receptors and interactions of these receptors

Conclusions: These results indicate that HAT may attack and activate PAR1, PAR2 and PAR3 in HBECs. These PARs, particularly PAR2 and PAR3, are intimately associated with IL-8 synthesis in HBECs, by mutual interrelations.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Miki, M., Yasuoka, S., Tsutsumi, R., Takeuchi, Y., Miki, K., Kitada, S. Tags: Airway cell biology and immunopathology Source Type: research