NF-kB activation in cystic fibrosis: The dream of A20

In conclusion, high expression of the repressor DREAM inhibits A20 transcription in CF epithelial cells. Our work suggests an important role of the A20-DREAM axis in (innate) inflammation, providing a new molecular target for the development of innovative anti-inflammatory therapies.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Momtazi, G., Elbanna, A., Finnegan, S., Heritier, M., Lavery, L., Mccollum, K., Naranjo, J., Schock, B. Tags: Airway cell biology and immunopathology Source Type: research