Hypoxia-inducible factor pathway activation promotes bone-type collagen cross-linking in Idiopathic Pulmonary Fibrosis

Conclusions: Our results suggest that HIF pathway activation via LH2/LOXL2 may be a core regulator of bone-type collagen fibrillogenesis in IPF.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Brereton, C. J., Yao, L., Bell, J., Conforti, F., Alzetani, A., Fabre, A., Marshall, B. G., Richeldi, L., Davies, D. E., Wang, Y., Jones, M. G. Tags: Mechanisms of lung injury and repair Source Type: research