Cigarette smoke exposure decreases CFLAR expression in bronchial epithelium, augmenting susceptibility for cell death and DAMP release

In conclusion, CS exposure decreases CFLAR expression, which might increase susceptibility to immunogenic cell death. Our study suggests that susceptibility for CS-induced airway inflammation is driven by dysregulated cell death machinery, which may be used at target for future COPD treatments.

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Pouwels, S. D., Faiz, A., Heijink, I. H., Vermeulen, C. J., Guryev, V., Van Den Berge, M., Nawijn, M. C. Tags: Mechanisms of Lung Injury and Repair Source Type: research