Lysosomal dysfunction in COPD pathogenesis

Conclusion: These findings suggest that accumulation of dysfunctional lysosome, which is attributed to reduced TRIM16-mediated lysophagy, can be associated with enhanced epithelial cell damage during COPD pathogenesis.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Saito, N., Araya, J., Ito, A., Hosaka, Y., Ichikawa, A., Kadota, T., Nakano, T., Yoshida, M., Fujita, Y., Utsumi, H., Hashimoto, M., Wakui, H., Minagawa, S., Hara, H., Numata, T., Kaneko, Y., Kuwano, K. Tags: Airway cell biology and immunopathology Source Type: research