Inhibition of the Arp2/3 complex inhibits lung myofibroblast differentiation in vitro and attenuates bleomycin-induced pulmonary fibrosis in mice

Conclusion: Increased expression of Arp2/3 was observed both in IPF fibroblasts and in bleomycin-exposed mouse lungs. CK666 and siARPC2 attenuated profibrotic differentiation of lung fibroblasts. CK666 attenuated bleomycin-induced lung fibrosis in vivo. Arp2/3 Inhibition may be an attractive new therapy for IPF and other fibrotic interstitial lung diseases.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Mergault, C., Lisee, F., Tiroille, V., Heuze-VourcH, N., Parent, C., Sizaret, D., Marchand-Adam, S., Plantier, L. Tags: Mechanisms of lung injury and repair Source Type: research