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Source: BMC Cancer

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Total 95 results found since Jan 2013.

P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement
Conclusion: P-gp over-expression is a possible mechanism of acquired resistance to 17-DMAG in cells with ALK rearrangement.
Source: BMC Cancer - July 29, 2015 Category: Cancer & Oncology Authors: Hee KimKye LeeYoung KimYun ChoiJung-Eun LeeChang ChoiIn-Jeoung BaekJin RhoJae Lee Source Type: research

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes
Conclusions: Our data suggest that the truncated PPARα splice variant functions as an endogenous inhibitor of proliferative and pro-inflammatory genes in human cells and that its absence in mouse may explain species-specific differences in fibrate-induced hepatocarcinogenesis.
Source: BMC Cancer - June 30, 2015 Category: Cancer & Oncology Authors: Maria ThomasChristine BayhaKathrin KleinSimon MüllerThomas WeissMatthias SchwabUlrich Zanger Source Type: research

Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
Conclusions: Together, these data highlight a broader role for dysregulated MAPK7 in driving tumorigenesis within niche populations of highly prevalent tumor types, and describe current efforts in establishing a robust drug discovery screening cascade.
Source: BMC Cancer - June 4, 2015 Category: Cancer & Oncology Authors: Paul GavineMei WangDehua YuEva HuChunlei HuangJenny XiaXinying SuJoan FanTianwei ZhangQingqing YeLi ZhengGuanshan ZhuZiliang QianQingquan LuoYing HouQunsheng Ji Source Type: research

Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival
Conclusion: We have shown that combined ↑cancer and ↑stromal cell CXCL16 expression is an independent positive prognostic factor in NSCLC. Further studies are warranted to elucidate the biological mechanism underlying this finding.
Source: BMC Cancer - May 29, 2015 Category: Cancer & Oncology Authors: Sigurd HaldYury KiselevSamer Al-SaadElin RichardsenCharles JohannessenMarte EilertsenThomas KilvaerKhalid Al-ShibliSigve AndersenLill-Tove BusundRoy BremnesTom Donnem Source Type: research

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells
Conclusions: This study illustrates for the first time that, in contrast to hepatic and adipose tissue, estrogen induces SCD-1 expression and activity in breast carcinoma cells. These results support SCD-1 as a therapeutic target in estrogen-sensitive breast cancer.
Source: BMC Cancer - May 29, 2015 Category: Cancer & Oncology Authors: Anissa BelkaidSabrina DuguayRodney OuelletteMarc Surette Source Type: research

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation
Conclusions: Our data indicate that i) functional Cx43 is required for mural cell-induced endothelial quiescence, and ii) downregulation of Cx43 GJ by tumors frees endothelium to respond to angiogenic cues. These data define a novel and important role for maintained Cx43 function in regulation of vessel quiescence, and suggest its loss may contribute to pathological tumor angiogenesis.
Source: BMC Cancer - May 23, 2015 Category: Cancer & Oncology Authors: Mayur ChoudharyChristine NaczkiWenhong ChenKeith BarlowL. CaseLinda Metheny-Barlow Source Type: research

Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes
In this study, we aimed to explore the role of MSK1 in Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1)-promoted carcinogenesis of nasopharyngeal carcinoma (NPC). Methods: The level of MSK1 phosphorylation at Thr581 was detected by the immunohistochemical analysis in NPC tissues and normal nasopharynx tissues, and its correlation with LMP1 was analyzed in NPC tissues and cell lines. Using MSK1 inhibitor H89 or small interfering RNA (siRNA)-MSK1, the effects of MSK1 on LMP1-promoted CNE1 cell proliferation and transformation were evaluated by CCK-8 assay, flow cytometry and focus-forming assay respectively. Further...
Source: BMC Cancer - May 10, 2015 Category: Cancer & Oncology Authors: Binbin LiZheng WanGuoliang HuangZunnan HuangXiangning ZhangDan LiaoShengqun LuoZhiwei He Source Type: research

High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy
Conclusions: KPNA2 is a novel independent prognostic marker for bladder recurrence, DFS and OS of UTUC patients who have undergone RNU. Moreover, these data suggest that KPNA2 may be a promising therapeutic target for UTUC.
Source: BMC Cancer - May 9, 2015 Category: Cancer & Oncology Authors: Bentao ShiBoxing SuDong FangYuan TangGengyan XiongZhongqiang GuoQun HeXinyu YangWei ZhaoYinglu GuoXuesong LiLiqun Zhou Source Type: research

Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck
Conclusions: Our findings suggest that WT1 and p63 act as oncogenes in SCCHN, affecting multiple genes involved in cancer cell growth.
Source: BMC Cancer - May 1, 2015 Category: Cancer & Oncology Authors: Xingru LiSofia OttossonSihan WangEmma JernbergLinda BoldrupXiaolian GuKarin NylanderAihong Li Source Type: research

The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion
Conclusions: These results suggest that IMP3 facilitates PDAC progression by enhancing the pro-metastatic behaviour of tumour cells.
Source: BMC Cancer - April 11, 2015 Category: Cancer & Oncology Authors: Clarissa PasiliaoChe-Wei ChangBrent SutherlandShannon ValdezDavid SchaefferDonald YappSylvia Ng Source Type: research

The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells
Conclusions: These results reveal that EphB4 regulates integrin β8 expression and that integrin β8 plays a hitherto unrecognized role in the motility of prostate cancer cells and thus targeting integrin β8 may be a new treatment strategy for prostate cancer.
Source: BMC Cancer - March 22, 2015 Category: Cancer & Oncology Authors: Inga Mertens-WalkerBruno FernandiniMohanan MaharajAnja RockstrohColleen NelsonAdrian HeringtonSally-Anne Stephenson Source Type: research

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways
Conclusions: TK1 was responsible for anticancer activity of dT-QX while levels of TYMP counteracted such an activity. The counteraction by TYMP could be overcome with RNA silencing to significantly enhance the dT-QX selectivity in cancer cells.
Source: BMC Cancer - March 21, 2015 Category: Cancer & Oncology Authors: Qiong WeiHaijuan LiuHonghao ZhouDejun ZhangZhiwei ZhangQibing Zhou Source Type: research

Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer
Conclusions: These results suggest that SMC1A plays an essential role in the development of CRC and may be a predictive factor in patients with CRC. The inhibition of SMC1A may serve as a promising therapeutic strategy for human CRC.
Source: BMC Cancer - March 4, 2015 Category: Cancer & Oncology Authors: Jianwei WangShaojun YuLiming CuiWenhui WangJun LiKe WangXinyuan Lao Source Type: research

MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells
Conclusion: The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation, which would be helpful in developing miRNA-based treatments for ESCC.
Source: BMC Cancer - January 31, 2015 Category: Cancer & Oncology Authors: Tingting YuRisheng CaoShuo LiMingen FuLihua RenWeixu ChenHong ZhuQiang ZhanRuihua Shi Source Type: research

Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein
Conclusions: Our results demonstrate existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6. Implications: miR-21 and Let-7a along with STAT3 may prove useful targets for pharmacological intervention for management of cervical cancer.
Source: BMC Cancer - December 23, 2014 Category: Cancer & Oncology Authors: Gauri ShishodiaGaurav VermaYogesh SrivastavaRavi MehrotraBhudev DasAlok Bharti Source Type: research