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Source: BMC Cancer

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Total 95 results found since Jan 2013.

Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes
Conclusions: Our results indicate that the metabolic defects introduced by siRNA silencing of metabolic enzymes TKT or AK2 may be compensated by alternative feedback metabolic mechanisms, suggesting that cancer cells may overcome single defective pathways through secondary metabolic network adaptations. The highly robust nature of oral cancer cell metabolism implies that a systematic medical approach targeting multiple metabolic pathways may be needed to accomplish the continued improvement of cancer treatment.
Source: BMC Cancer - March 25, 2014 Category: Cancer & Oncology Authors: Min ZhangYang ChaiJeffrey BrumbaughXiaojun LiuRamin RabiiSizhe FengKaori MisunoDiana MessadiShen Hu Source Type: research

Role of Pax8 in the regulation of MET and RON receptor Tyrosine Kinases in non-small cell lung cancer
Conclusion: PAX8 provides signals for growth and motility of NSCLC cells and is necessary for MET and RON expression. Further investigations are necessary to investigate the therapeutic potential of PA8 in NSCLC.
Source: BMC Cancer - March 14, 2014 Category: Cancer & Oncology Authors: Rajani KantetiEssam El-HashaniImmanuel DhanasinghMaria TretiakovaAliya HusainSherven SharmaJay SharmaEverett VokesRavi Salgia Source Type: research

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells
Conclusion: Our overall results demonstrate that mPEPCK is a useful predictor of a response to chemoradiotherapy in patients with rectal cancer.
Source: BMC Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Ji-Won ParkSeung KimWon KimJun HongKyung-Hee KimHyun YeoJae LeeM KimJong KimSe YangDae KimJae OhJae ChoByong Yoo Source Type: research

Increased paired box transcription factor 8 has a survival function in Glioma
Conclusions: PAX8 is increased in the majority of glioblastomas and promoted cell survival. Because PAX8 is absent in normal brain tissue, it may be a promising therapeutic target pathway for treating aggressive gliomas.
Source: BMC Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Noelyn HungYu-Jen ChenAhmad TahaMagnus OlivecronaRonald BoetAnna WilesTracy WarrAlisha ShawRamona EiholzerBruce BaguleyMichael EcclesAntony BraithwaiteMartin MacFarlaneJanice RoydsTania Slatter Source Type: research

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
Background: Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and assessed proteomic changes associated with ARID1A mutation/BAF250a expression in EC and CCC. Methods: Immunohistochemistry (IHC) for BAF250a expression was performed on 127 chemotherapy-naive ovarian carcinomas (33...
Source: BMC Cancer - February 22, 2014 Category: Cancer & Oncology Authors: Kimberly WiegandBryan HennessySamuel LeungYemin WangZhenlin JuMollianne McGahrenSteve KallogerSarah FinlaysonKatherine Stemke-HaleYiling LuFan ZhangMichael AnglesioBlake GilksGordon MillsDavid HuntsmanMark Carey Source Type: research

Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice
Conclusions: EMF-guided 131I-hVEGF siRNA/SilenceMag exhibited an antitumor effect. The synergic therapy of 131I-hVEGF siRNA/SilenceMag might be a promising future treatment option against HCC with the dual functional properties of tumor therapy and imaging.
Source: BMC Cancer - February 21, 2014 Category: Cancer & Oncology Authors: Jing ChenShu ZhuLiangqian TongJiansha LiFei ChenYunfeng HanMing ZhaoWei Xiong Source Type: research

PKC alpha regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer
Conclusions: The present study identified netrin-1/UNC5B, which could be regulated by PKC signaling, was important mediators of bladder cancer progression.
Source: BMC Cancer - February 15, 2014 Category: Cancer & Oncology Authors: Jiao LiuChui-ze KongDa-xin GongZhe ZhangYu-yan Zhu Source Type: research

The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells
Conclusions: The findings of this study demonstrate that ROCK-1 protein plays a key role in regulating metastasis and invasion of Y79 cells, suggesting that the ROCK-1 dependent pathway may be a potential target for therapy of Rb.
Source: BMC Cancer - February 14, 2014 Category: Cancer & Oncology Authors: Jing WangXiao-Hong LiuZi-Jian YangBing XieYi-Sheng Zhong Source Type: research

FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer
Conclusions: These results suggest that FOXA1 promotes cell proliferation by AR and activates Notch pathway. It indicated that FOXA1 and AR may serve as potential gene therapy in EC.
Source: BMC Cancer - February 11, 2014 Category: Cancer & Oncology Authors: Meiting QiuWei BaoJingyun WangTingting YangXiaoying HeYun LiaoXiaoping Wan Source Type: research

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells
Conclusions: Findings reported herein uncover a mechanism for the anti-tumor activity of metformin in prostate cancer, which is independent of its anti-diabetic effects. These data provide a rationale for the use of metformin in the treatment of hormone naive and castration-resistant prostate cancer and suggest AR is an important indirect target of metformin.
Source: BMC Cancer - January 31, 2014 Category: Cancer & Oncology Authors: Ummuhan DemirAndrea KoehlerRainer SchneiderSusann SchweigerHelmut Klocker Source Type: research

PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells
Conclusions: These results suggest that the synergy between PMA and apicularen A is involved by PKCalpha activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer.
Source: BMC Cancer - January 22, 2014 Category: Cancer & Oncology Authors: Kang-Sik SeoJong-Seok KimJi-Hoon ParkKyoung-Sub SongEun-Jin YunJong-Il ParkGi Ryang KweonWan-Hee YoonKyu LimByung-Doo Hwang Source Type: research

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
Conclusions: Overall, these results suggest that further investigation of CDK1 inhibition as a potential therapy for MYC-dependent breast cancer is warranted.
Source: BMC Cancer - January 20, 2014 Category: Cancer & Oncology Authors: Jian KangC SergioRobert SutherlandElizabeth Musgrove Source Type: research

The novel IGF-IR/Akt¿dependent anticancer activities of glucosamine
Conclusions: Taken together, our results suggest that targeting the IGF-1R/Akt pathway with glucosamine may be an effective therapeutic strategy for treating some type of cancer.
Source: BMC Cancer - January 20, 2014 Category: Cancer & Oncology Authors: Ki-Hoon SongJu-Hee KangJong-Kyu WooJeong-Seok NamHye-Young MinHo-Young LeeSoo-Youl KimSeung-Hyun Oh Source Type: research

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer
Conclusions: These observations imply that the frequently noted loss-of-function of NKX3.1 cooperates with the activation of TMPRSS2-ERG fusions in prostate tumorigenesis.
Source: BMC Cancer - January 13, 2014 Category: Cancer & Oncology Authors: Rajesh ThangapazhamFrancisco SaenzShilpa KattaAhmed MohamedShyh-Han TanGyorgy PetrovicsShiv SrivastavaAlbert Dobi Source Type: research

High epiregulin expression in human U87 glioma cells relies on IRE1alpha and promotes autocrine growth through EGF receptor
Conclusion: EREG may contribute to glioma progression under the control of IRE1alpha, as exemplified here by the autocrine proliferation loop mediated in U87 cells by the growth factor through ErbB1.
Source: BMC Cancer - December 13, 2013 Category: Cancer & Oncology Authors: Gregor AufArnaud JabouilleMaylis DeluginSylvaine GuéritRaphael PineauSophie NorthNatalia PlatonovaMarlène MaitreAlexandre FavereauxPeter VajkoczyMasaharu SenoAndreas BikfalviDmitri MinchenkoOleksandr MinchenkoMichel Moenner Source Type: research