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Source: BMC Cancer

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Total 95 results found since Jan 2013.

Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence
The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ...
Source: BMC Cancer - July 6, 2020 Category: Cancer & Oncology Authors: Jennifer L. S. Willoughby, Kelly George, Mark P. Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E. Schaus, Kevin Fitzgerald, Jagesh Shah and Ulla Hansen Tags: Research article Source Type: research

Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells
This study investigated the effects of SALL2 on human ovarian carcinoma (OC) A2780 cells and the probable mechanism.
Source: BMC Cancer - December 11, 2017 Category: Cancer & Oncology Authors: Fang Miao, Xueshan Zhang, Yanning Cao, Yue Wang and Xiaoshu Zhang Tags: Research article Source Type: research

Methodological study to evaluate the psychometric properties of FACIT-CD in a sample of Brazilian women with cervical intraepithelial neoplasia
The occurrence of cervical intraepithelial neoplasia (CIN) is associated with changes in health-related quality of life, including psychological factors, such as fear and shame, and changes in sexuality and se...
Source: BMC Cancer - October 16, 2017 Category: Cancer & Oncology Authors: Cristiane Menezes Sirna Fregnani, Jos é Humberto Tavares Guerreiro Fregnani and Adhemar Longatto-Filho Tags: Research article Source Type: research

Transarterial chemoembolization of hepatocellular carcinoma in a rat model: the effect of additional injection of survivin siRNA to the treatment protocol
Transarterial chemoembolization is one of the most widely accepted interventional treatment options for treatment of hepatocellular carcinoma. Still there is a lack of a standard protocol regarding the injecte...
Source: BMC Cancer - May 23, 2016 Category: Cancer & Oncology Authors: Thomas J. Vogl, Elsie Oppermann, Jun Qian, Ulli Imlau, Andreas Tran, Yousef Hamidavi, Huedayi Korkusuz, Wolf Otto Bechstein, Nour-Eldin Abdel-Rehim Nour-Eldin, Tatjana Gruber-Rouh, Renate Hammerstingl and Nagy Naguib Naeem Naguib Source Type: research

Neuropilin-2 induced by transforming growth factor-β augments migration of hepatocellular carcinoma cells
Conclusions: These data suggest that NRP2 associates with a less differentiated, mesenchymal-like HCC phenotype and that NRP2 plays an important role in tumor cell migration upon TGF-β-dependent HCC progression.
Source: BMC Cancer - November 16, 2015 Category: Cancer & Oncology Authors: Philipp WittmannMarkus GrubingerChristian GrögerHeidemarie HuberWolfgang SieghartMarkus Peck-RadosavljevicWolfgang Mikulits Source Type: research

AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas
Conclusions: Our results suggest that AXL signaling contributes to the aggressiveness of DDLPS and PLS, and that AXL is therefore a potential therapeutic target for treatment of these rare, yet devastating tumors.
Source: BMC Cancer - November 14, 2015 Category: Cancer & Oncology Authors: Caitlin MayJeannine GarnettXiaoYan MaSharon LandersDavis IngramElizabeth DemiccoGhadah Al SannaaTona VuLixia HanYi ZhangChristine KivlinSvetlana BolshakovAzad KalamJuehui LiuFuguo ZhouDominique BroccoliWei-Lien WangAlexander LazarRaphael PollockDina LevKe Source Type: research

Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells
Background: Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FIH) hydroxylase enzymes, which require ascorbic acid as a co-factor for optimal function. Depleted intra-tumoral ascorbic acid may thus play a role in the loss of HIF-1α regulation in melanoma. These studies assess the ability of ascorbic acid to reduce HIF-1α protein and transcriptional activity in metastatic melanoma and reduce its invasive potential. Methods: HIF-1α protein was evaluated by wester...
Source: BMC Cancer - November 7, 2015 Category: Cancer & Oncology Authors: Sarah MilesAdam FischerSandeep JoshiRichard Niles Source Type: research

Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells
Conclusions: Taken together, this work presents the novel anticancer candidate WZ35 for the treatment of prostate cancer, and importantly, reveals that increased ROS generation might be an effective strategy in human prostate cancer treatment.
Source: BMC Cancer - November 6, 2015 Category: Cancer & Oncology Authors: Xiuhua ZhangMinxiao ChenPeng ZouKarvannan KanchanaQiaoyou WengWenbo ChenPeng ZhongJiansong JiHuiping ZhouLangchong HeGuang Liang Source Type: research

MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer
Conclusions: These findings demonstrate that the overexpression of miR-363 reduces cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN.
Source: BMC Cancer - November 6, 2015 Category: Cancer & Oncology Authors: Bhavana ChapmanAbigail WaldParvez AkhtarAna MunkoJingjing XuSandra GibsonJennifer GrandisRobert FerrisSaleem Khan Source Type: research

Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer
Conclusions: Our findings support the role of MIF in tumor aggressiveness and suggest its potential application as a therapeutic target for gallbladder cancer.
Source: BMC Cancer - November 4, 2015 Category: Cancer & Oncology Authors: Tejaswini SubbannayyaPamela Leal-RojasMustafa BarbhuiyaRemya RajaSantosh RenuseGajanan SatheSneha PintoNazia SyedVishalakshi NanjappaArun PatilPatricia GarciaNandini SahasrabuddheBipin NairRafael Guerrero-PrestonSanjay NavaniPramod TiwariVani SantoshDavid Source Type: research

CA1 contributes to microcalcification and tumourigenesis in breast cancer
Conclusion: The results of this study suggested that CA1 is a potential oncogene and that it contributes to abnormal cell calcification, apoptosis and migration in breast cancer.
Source: BMC Cancer - October 12, 2015 Category: Cancer & Oncology Authors: Yabing ZhengBing XuYan ZhaoHe GuChang LiYao WangXiaotian Chang Source Type: research

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy
Background: Multi-drug Resistance associated Protein-1 (MRP1) can export chemotherapeutics from cancer cells and is implicated in chemoresistance, particularly as is it known to be up-regulated by chemotherapeutics. Our aims in this study were to determine whether activation of Notch signalling is responsible for chemotherapy-induced MRP1 expression Notch in breast cancers, and whether this pathway can be manipulated with an inhibitor of Notch activity. Methods: MRP1 and Notch1 were investigated in 29 patients treated with neoadjuvant chemotherapy (NAC) for breast cancer, using immunohistochemistry on matched biopsy (pre-N...
Source: BMC Cancer - September 11, 2015 Category: Cancer & Oncology Authors: Baek KimSam StephenAndrew HanbyKieran HorganSarah PerryJulie RichardsonElizabeth RoundhillElizabeth ValleleyEldo VergheseBethany WilliamsJames ThorneThomas Hughes Source Type: research

DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines
Conclusions: We identified DKK1 as a possible marker of a cisplatin-refractory phenotype and as a potential novel therapeutic target to improve platinum response of NSCLC cells.
Source: BMC Cancer - September 9, 2015 Category: Cancer & Oncology Authors: Hogir SalimDali ZongPetra HåågMetka NovakBirgitta MörkRolf LewensohnLovisa LundholmKristina Viktorsson Source Type: research

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13
Conclusions: We show that the PKA-anchoring protein AKAP13 is essential for the phosphorylation of ERαS305, which leads to tamoxifen resistance both in cell lines and tamoxifen-treated breast cancer patients.
Source: BMC Cancer - August 14, 2015 Category: Cancer & Oncology Authors: Cristiane Bentin ToaldoXanthippi AlexiKarin BeelenMarleen KokMichael HauptmannMaurice JansenEls BernsJacques NeefjesSabine LinnRob MichalidesWilbert Zwart Source Type: research

Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells
Conclusions: Evidence of EV-mediated induction of malignant phenotype, and reversal of malignant phenotype, provides rational basis for further study of the role of EVs in tumorigenesis. Identification of 14-3-3 zeta/delta as up-regulated in malignancy suggests its potential as a putative drug target for the treatment of colorectal cancer.
Source: BMC Cancer - August 1, 2015 Category: Cancer & Oncology Authors: Hillary MulveyAudrey ChangJason AdlerMichael Del TattoKimberly PerezPeter QuesenberryDevasis Chatterjee Source Type: research