Filtered By:
Source: BMC Cancer

This page shows you your search results in order of date. This is page number 7.

Order by Relevance | Date

Total 95 results found since Jan 2013.

The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma
Conclusion: Notch1 may induce a migratory effect in ICC by causing an epithelial-mesenchymal transition and activating Rac1 and could serve as a novel diagnostic and therapeutic target in patients with ICC.
Source: BMC Cancer - May 20, 2013 Category: Cancer & Oncology Authors: Qi ZhouYafeng WangBaogang PengLijian LiangJiaping Li Source Type: research

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-beta
Conclusions: The results suggest that imatinib mesylate may be useful in the treatment of MPNST patients and in vitro studies may help select cells that are sensitive to imatinib mesylate in vivo.
Source: BMC Cancer - May 4, 2013 Category: Cancer & Oncology Authors: Jun OhishiMikiko AokiKazuki NabeshimaJunji SuzumiyaTamotsu TakeuchiAkira OgoseMichiyuki HakozakiYuichi YamashitaHiroshi Iwasaki Source Type: research

Expressional alterations in functional ultra-conserved non-coding RNAs in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells
Conclusions: Our results indicate that significant numbers of T-UCRs have altered expression levels in response to ATRA. While the precise roles that T-UCRs might play in cancer or in normal development are largely unknown and an important area for future study, our findings strongly indicate that the function of non-coding RNA T-UC.300A is connected with proliferation, invasion and the inhibition of differentiation of neuroblastoma cell lines prior to ATRA treatment.
Source: BMC Cancer - April 8, 2013 Category: Cancer & Oncology Authors: Karen WattersKenneth BryanNiamh FoleyMaria MeehanRaymond Stallings Source Type: research

Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines
Conclusions: This discrepancy between the effects of Rac3 knockdown in the two cell lines could be explained as follows: in the MDA-MB-231 line, the Rac3-dependent aggressiveness of the cancer cells is due to the Rac3/ERK-2/NF-kappaB signaling pathway, which is responsible for MMP-9, interleukin-6, -8 and GRO secretion, as well as the resistance to TNF-induced apoptosis, whereas in the MCF-7 line, this pathway is not functional because of the low expression of NF-kappaB subunits in these cells. Rac3 may be a potent target for inhibiting aggressive breast cancer.
Source: BMC Cancer - February 6, 2013 Category: Cancer & Oncology Authors: Caroline GestUlrich JoimelLimin HuangLinda-Louise PritchardAlexandre PetitCharlène DulongCatherine BuquetChao-Quan HuPezhman MirshahiMarc LaurentFrançoise Fauvel-LafèveLionel CazinJean-Pierre VannierHe LuJeannette SoriaHong LiRémi VarinClaudine Soria Source Type: research

Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
Conclusion: In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. Garcinol treatment alters expression of chromatin modifying enzymes in MCF7 cells, resulting in reprogramming of key histone and p53 PTMs and growth arrest, underscoring its potential as a cancer chemopreventive agent.
Source: BMC Cancer - January 29, 2013 Category: Cancer & Oncology Authors: Hilary CollinsMagdy AbdelghanyMarie MessmerBaigong YueSian DeevesKarin KindleKempegowda MantelinguAkhmed AslamG WinklerTapas KunduDavid Heery Source Type: research