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Source: BMC Cancer

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Total 95 results found since Jan 2013.

High epiregulin expression in human U87 glioma cells relies on IRE1¿ and promotes autocrine growth through EGF receptor
Conclusion: EREG may contribute to glioma progression under the control of IRE1alpha, as exemplified here by the autocrine proliferation loop mediated in U87 cells by the growth factor through ErbB1.
Source: BMC Cancer - December 13, 2013 Category: Cancer & Oncology Authors: Gregor AufArnaud JabouilleMaylis DeluginSylvaine GuéritRaphael PineauSophie NorthNatalia PlatonovaMarlène MaitreAlexandre FavereauxPeter VajkoczyMasaharu SenoAndreas BikfalviDmitri MinchenkoOleksandr MinchenkoMichel Moenner Source Type: research

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells
Conclusions: Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options.
Source: BMC Cancer - December 5, 2013 Category: Cancer & Oncology Authors: Maximilian LinxweilerStefan SchorrNico SchäubleMartin JungJohannes LinxweilerFrank LangerHans-Joachim SchäfersAdolfo CavaliéRichard ZimmermannMarkus Greiner Source Type: research

Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival
Conclusion: Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times. DSS1 is necessary to rescue cells from DNA damage, but high DSS1 expression increases drug resistance. We suggest that DSS1 expression could be a useful marker for drug resistance in breast cancers, and DSS1 knockdown can induce tumor apoptosis when used in combination with DNA-damaging drugs.
Source: BMC Cancer - December 1, 2013 Category: Cancer & Oncology Authors: Andri RezanoKazuhiko KuwaharaMutsuko Yamamoto-IbusukiMasahiro KitabatakePenpak MoolthiyaSuchada PhimsenTaiji SudaShigenobu ToneYutaka YamamotoHirotaka IwaseNobuo Sakaguchi Source Type: research

Wnt signaling in triple negative breast cancer is associated with metastasis
Conclusion: These data implicate transcriptional Wnt signaling as a hallmark of TNBC disease associated with specific metastatic pathways.
Source: BMC Cancer - November 10, 2013 Category: Cancer & Oncology Authors: Nandini DeyBenjamin BarwickCarlos MorenoMaja Ordanic-KodaniZhengjia ChenGabriella Oprea-IliesWeining TangCharles CatzavelosKimberly KerstannGeorge SledgeMark AbramovitzMark BouzykPradip DeBrian Leyland-Jones Source Type: research

Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses
The circadian clock and cell cycle are two global regulatory systems that have pervasive behavioral and physiological effects on eukaryotic cells, and both play a role in cancer development. Recent studies have indicated that the circadian and cell cycle regulator, TIMELESS, may serve as a molecular bridge between these two regulatory systems. To assess the role of TIMELESS in tumorigenesis, we analyzed TIMELESS expression data from publically accessible online databases. A loss-of-function analysis was then performed using TIMELESS-targeting siRNA oligos followed by a whole-genome expression microarray and network analysi...
Source: BMC Cancer - October 25, 2013 Category: Cancer & Oncology Authors: Yingying MaoAlan FuDerek LeadererTongzhang ZhengKun ChenYong Zhu Source Type: research

Evaluation of a curcumin analog as an anti-cancer agent inducing ER stress-mediated apoptosis in non-small cell lung cancer cells
Conclusions: A new monocarbonyl analog of curcumin, B82, exhibited anti-tumor effects on H460 cells via an ER stress-mediated mechanism. B82 could be further explored as a potential anticancer agent for the treatment of NSCLC.
Source: BMC Cancer - October 24, 2013 Category: Cancer & Oncology Authors: Zhiguo LiuYusheng SunLuqing RenYi HuangYuepiao CaiQiaoyou WengXueqian ShenXiaokun LiGuang LiangYi Wang Source Type: research

HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis
Conclusion: the present study confirms the overexpression of HOXB7 mRNA expression in PDAC and demonstrates that decreasing its protein level by siRNA could significantly increase apoptosis and modulate several biological processes. HOXB7 might be a promising target for future therapies.
Source: BMC Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Thais ChileMaria FortesMaria Corrêa-GiannellaHelena BrentaniDurvanei AugustoRenato PugaVanessa de PaulaMarcia KubruslyEstela NovakTelésforo BacchellaRicardo Giorgi Source Type: research

HRG-beta1-driven ErbB3 signaling induces epithelial--mesenchymal transition in breast cancer cells
Conclusions: Our data suggest that HRG-beta1 and ErbB3 induce EMT, cancer cell migration and invasion through the PI3k/Akt-phospho-Smad2-Snail signaling pathway in SK-BR-3 and MCF7 breast cancer cells.
Source: BMC Cancer - August 12, 2013 Category: Cancer & Oncology Authors: Jinkyoung KimHoiseon JeongYoungseok LeeChungyeul KimHankyeom KimAeree Kim Source Type: research

HRG-ß1-driven ErbB3 signaling induces epithelial¿mesenchymal transition in breast cancer cells
Conclusions: Our data suggest that HRG-β1 and ErbB3 induce EMT, cancer cell migration and invasion through the PI3k/Akt-phospho-Smad2-Snail signaling pathway in SK-BR-3 and MCF7 breast cancer cells.
Source: BMC Cancer - August 12, 2013 Category: Cancer & Oncology Authors: Jinkyoung KimHoiseon JeongYoungseok LeeChungyeul KimHankyeom KimAeree Kim Source Type: research

Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer
Conclusions: We therefore conclude that abnormal Pygo2 protein expression may be a marker for advanced NSCLC. Furthermore, Pygo2 knockdown suppresses cell growth.
Source: BMC Cancer - July 16, 2013 Category: Cancer & Oncology Authors: Yang LiuQian-Ze DongSi WangChang-Qing FangYuan MiaoLiang WangMing-Zhu LiEn-Hua Wang Source Type: research

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases
Conclusion: PEI-mediated delivery of sticky siRNAs targeting genes involved in tumor progression such as survivin and cyclin B1, either alone or in combination with chemotherapeutic drugs, represents a promising strategy for melanoma treatment.
Source: BMC Cancer - July 9, 2013 Category: Cancer & Oncology Authors: Valerie KedingerAline MeulleOmar ZounibMarie-Elise BonnetJean-Baptiste GossartElodie BenoitMelanie MessmerPattabhiraman ShankaranarayananJean-Paul BehrPatrick ErbacherAnne-Laure Bolcato-Bellemin Source Type: research

The cysteinyl leukotriene 2 receptor contributes to all-trans retinoic acid-induced differentiation of colon cancer cells
Conclusions: This study identifies a novel mechanism of action for ATRA in colorectal cancer cell differentiation and demonstrates that retinoids can have anti-tumorigenic effects through their action on the cysteinyl leukotriene pathway.
Source: BMC Cancer - July 8, 2013 Category: Cancer & Oncology Authors: Astrid BengtssonGunilla JönssonCecilia MagnussonTavga SalimCecilia AxelssonAnita Sjölander Source Type: research

Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity
Conclusion: Sox2 regulates the invasiveness of BC cells via a mechanism that is dependent on Twist1 and the transcriptional status of Sox2. Our results have further highlighted a new level of biological complexity and heterogeneity of BC cells that may carry significant clinical implications.
Source: BMC Cancer - July 1, 2013 Category: Cancer & Oncology Authors: Fang WuXiaoxia YePeng WangKaren JungChengsheng WuDonna DouglasNorman KnetemanGilbert BigrasYupo MaRaymond Lai Source Type: research

Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2
Conclusion: Our study indicates that GnRH-II agonist promoted cell motility of endometrial cancer cells through the GnRH-I receptor via the phosphorylation of ERK1/2 and JNK, and the subsequent, MAPK-dependent activation of MMP-2. Our findings represent a new concept regarding the mechanism of GnRH-II-induced cell motility in endometrial cancer cells and suggest the possibility of exploring GnRH-II as a potential therapeutic target for the treatment of human endometrial cancer.
Source: BMC Cancer - June 20, 2013 Category: Cancer & Oncology Authors: Hsien-Ming WuHsin-Shih WangHong-Yuan HuangChyong-Huey LaiChyi-Long LeeYung-Kuei SoongPeter Leung Source Type: research

High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Conclusions: Our results suggest that Wee1 may be involved in the progression of vulvar carcinomas. Based on our in vitro results, Wee1 is unlikely to function as a target for mono-treatment of these patients.
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Gry MagnussenEllen HellesyltJahn NeslandClaes TropeVivi FlørenesRuth Holm Source Type: research