PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells
Conclusions:
These results suggest that the synergy between PMA and apicularen A is involved by PKCalpha activation and microtubule disruption, and that may inform the development of novel approaches to treat cancer.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Kang-Sik SeoJong-Seok KimJi-Hoon ParkKyoung-Sub SongEun-Jin YunJong-Il ParkGi Ryang KweonWan-Hee YoonKyu LimByung-Doo Hwang Source Type: research