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Source: Am J Physiol Cell Ph...
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Total 155 results found since Jan 2013.
Endothelial Upregulation of Mechanosensitive Channel Piezo1 in Pulmonary Hypertension
Am J Physiol Cell Physiol. 2021 Oct 20. doi: 10.1152/ajpcell.00147.2021. Online ahead of print.ABSTRACTPiezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary arterial hypertension (PAH). Pulmonary arterial endothelial cells (PAECs) are constantly under mechanic stretch and shear stress that are sufficient to activate Piezo channels. Here we report that Piezo1 is significantly upregulated in PAECs from patients with idiopathic PAH and ...
Source: Am J Physiol Cell Ph... - October 20, 2021 Category: Cytology Authors: Ziyi Wang Jiyuan Chen Aleksandra Babicheva Pritesh P Jain Marisela Rodriguez Ramon J Ayon Keeley S Ravellette Linda Wu Francesca Balistrieri Haiyang Tang Xiaomin Wu Tengteng Zhao Stephen M Black Ankit A Desai Joe G N Garcia Xin Sun John Y-J Shyy Daniela V Source Type: research
Novel HIF-1-target gene isthmin1 contributes to hypoxia-induced hyperpermeability of pulmonary microvascular endothelial cells monolayers
In this study, we assessed the role of AECII-derived ISM1 in hypoxia-induced PMVEC hyperpermeability with an AECII/PMVEC co-culture system and uncovered the underlying mechanism whereby hypoxia stimulates ISM1 gene expression. We found that ISM1 gene expression was upregulated in cultured AECII cells exposed to hypoxia (3% O2), and that AECII-derived ISM1 participated in hypoxia-induced hyperpermeability of PMVEC monolayers since siRNA-mediated knockdown of ISM1 in AECII markedly attenuated the increasement of PMVEC permeability in co-culture system under hypoxia. Additionally, we confirmed that ISM1 was regulated by hypox...
Source: Am J Physiol Cell Ph... - September 1, 2021 Category: Cytology Authors: Junxia Li Yiming Xia Zhizhong Huang Yan Zhao Renping Xiong Xiaoxu Li Qingyuan Huang Fabo Shan Source Type: research
Nicotinamide N-methyltransferase (NNMT) upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes
In this study, using AML12 cells, a non-transformed murine hepatocyte cell line, exposed to palmitate (a 16-C saturated fatty acid) as an experimental model, we investigated the role and mechanisms of nicotinamide N-methyltransferase (NNMT), a methyltransferase catalyzing nicotinamide methylation and degradation, in hepatic lipotoxicity. We initially identified activating transcription factor 4 (ATF4) as a major transcription factor for hepatic NNMT expression. Here, we demonstrated that palmitate upregulates NNMT expression via activating ATF4 in a mechanistic target of rapamycin complex 1 (mTORC1)-dependent mechanism in ...
Source: Am J Physiol Cell Ph... - August 11, 2021 Category: Cytology Authors: Alexandra Griffiths Jun Wang Qing Song Iredia D Iyamu Lifeng Liu Jooman Park Yuwei Jiang Rong Huang Zhenyuan Song Source Type: research
LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas
In conclusion, LRG1 promotes the corneal fibrotic response by stimulating neutrophils infiltration via the modulation of the IL-6/Stat3 signaling pathway. Therefore, LRG1 could be targeted as a promising therapeutic strategy for patients with corneal fibrosis.PMID:34260299 | DOI:10.1152/ajpcell.00517.2020
Source: Am J Physiol Cell Ph... - July 14, 2021 Category: Cytology Authors: Bingjie Yu Lingling Yang Shan Song Weina Li Huifeng Wang Jun Cheng Source Type: research
