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Source: Am J Physiol Cell Ph...
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Total 155 results found since Jan 2013.
MicroRNA-140 is not involved in sepsis-induced muscle atrophy
Am J Physiol Cell Physiol. 2023 Jul 24. doi: 10.1152/ajpcell.00157.2023. Online ahead of print.ABSTRACTSepsis is a life-threatening inflammatory response to infection, often accompanied by skeletal muscle atrophy. A previous study demonstrated that the administration of microRNA-140 (miR-140) attenuated lipopolysaccharides (LPS)-induced muscle atrophy, whereas miR-140 knockdown with siRNA promoted atrophy. Therefore, we investigated whether miR-140 is involved in LPS-induced muscle atrophy using a genetic model, miR-140-/- mice. We found that a single injection of LPS induced atrophy both in slow-twitch and fast-twitch mus...
Source: Am J Physiol Cell Ph... - July 24, 2023 Category: Cytology Authors: Jaehoon Shin Shigeru Miyaki Hiroshi Asahara Takayuki Akimoto Source Type: research
The Exocyst Complex is Required for the Trafficking and Delivery of KCa3.1 to the Basolateral Membrane of Polarized Epithelia
Am J Physiol Cell Physiol. 2023 May 1. doi: 10.1152/ajpcell.00374.2022. Online ahead of print.ABSTRACTControl of the movement of ions and water across epithelia is essential for homeostasis. Changing the number or activity of ion channels at the plasma membrane is a significant regulator of epithelial transport. In polarized epithelia, the intermediate-conductance calcium-activated potassium channel, KCa3.1 is delivered to the basolateral membrane where it generates and maintains the electrochemical gradients required for epithelial transport. The mechanisms that control the delivery of KCa3.1 to the basolateral membrane a...
Source: Am J Physiol Cell Ph... - May 1, 2023 Category: Cytology Authors: Matthew J E Logue Rachel E Farquhar Yoakim Eckhoff-Bj örngard Tanya T Cheung Daniel C Devor Fiona J McDonald Kirk L Hamilton Source Type: research
p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization
Am J Physiol Cell Physiol. 2023 Apr 24. doi: 10.1152/ajpcell.00425.2022. Online ahead of print.ABSTRACTEndothelial cell (EC) migration is critical for the repair of monolayer disruption following angioplasties, but migration is inhibited by lipid oxidation products, including lysophosphatidylcholine (lysoPC), which open canonical transient receptor potential 6 (TRPC6) channels. TRPC6 activation requires an increase in intracellular Ca2+ concentration ([Ca2+]i), the source of which is unknown. LysoPC can activate phospholipase A2 to release arachidonic acid (ArA). ArA can activate arachidonic acid-regulated calcium (ARC) ch...
Source: Am J Physiol Cell Ph... - April 24, 2023 Category: Cytology Authors: Pinaki Chaudhuri Priya Putta Michael A Rosenbaum Linda M Graham Source Type: research
MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression
This study aimed to determine the function of miR146a in the chondrogenic differentiation of MSCs and the potential mechanisms involved. MiR146a expression increased during chondrogenesis. MiR146a knockout (KO) led to the increased chondrogenesis of MSCs compared to that in wild-type (WT) MSCs, whereas the overexpression of miR146a by mimics resulted in the decreased chondrogenesis of MSCs, as determined by the mRNA expression of collagen, type II, alpha 1 (COL2A1), aggrecan, cartilage oligomeric matrix protein (COMP), and matrix metallopeptidase 13 (MMP13). Furthermore, cartilage defects could be treated better when injec...
Source: Am J Physiol Cell Ph... - March 20, 2023 Category: Cytology Authors: Yuhang Liu Xudong Zhang Xiaodong Chen Bingjun Zhang Liming Dai Chenglong Wang Yang Li Xiaoling Zhang Source Type: research
