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Source: Am J Physiol Cell Ph...
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Total 155 results found since Jan 2013.
Mitofusin 2 positively regulates Ca < sup > 2+ < /sup > signaling by tethering the sarcoplasmic reticulum and mitochondria in rat aortic smooth muscle cells
This study strongly suggests that Mfn2 is responsible for SR-mitochondria Ca2+ signaling by tethering mitochondria to SR, thereby regulating ATP production and proliferation of VSMCs.PMID:35704692 | DOI:10.1152/ajpcell.00274.2021
Source: Am J Physiol Cell Ph... - June 15, 2022 Category: Cytology Authors: Sou Inagaki Yoshiaki Suzuki Keisuke Kawasaki Rubii Kondo Yuji Imaizumi Hisao Yamamura Source Type: research
Chaperone Mediated Autophagy Protects Cardiomyocytes Against Hypoxic-Cell Death
This study for the first time establishes a protective role for CMA (via Lamp2a overexpression) against hypoxia-induced cardiomyocyte loss and reveals the intriguing possibility that CMA activation may offer a cardioprotective treatment for ischemic heart disease.PMID:35584327 | DOI:10.1152/ajpcell.00369.2021
Source: Am J Physiol Cell Ph... - May 18, 2022 Category: Cytology Authors: Rajeshwary Ghosh Jennifer Jason Gillaspie Kenneth S Campbell J David Symons Sihem Boudina James Scott Pattison Source Type: research
Endothelial Upregulation of Mechanosensitive Channel Piezo1 in Pulmonary Hypertension
Am J Physiol Cell Physiol. 2021 Oct 20. doi: 10.1152/ajpcell.00147.2021. Online ahead of print.ABSTRACTPiezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary arterial hypertension (PAH). Pulmonary arterial endothelial cells (PAECs) are constantly under mechanic stretch and shear stress that are sufficient to activate Piezo channels. Here we report that Piezo1 is significantly upregulated in PAECs from patients with idiopathic PAH and ...
Source: Am J Physiol Cell Ph... - October 20, 2021 Category: Cytology Authors: Ziyi Wang Jiyuan Chen Aleksandra Babicheva Pritesh P Jain Marisela Rodriguez Ramon J Ayon Keeley S Ravellette Linda Wu Francesca Balistrieri Haiyang Tang Xiaomin Wu Tengteng Zhao Stephen M Black Ankit A Desai Joe G N Garcia Xin Sun John Y-J Shyy Daniela V Source Type: research
