Filtered By:
Education: Learning
This page shows you your search results in order of date. This is page number 3.
Order by Relevance | Date
Total 122 results found since Jan 2013.
HMGB1-NLRP3-P2X7R pathway participates in PM < sub > 2.5 < /sub > -induced hippocampal neuron impairment by regulating microglia activation
In this study, we focused on the role of HMGB1-NLRP3-P2X7R pathway which mediated the microglia activation in hippocampal neurons impairment induced by PM2.5 using a co-culture model of microglia and hippocampal neurons. We found that PM2.5 resulted in activated microglia and HMGB1-NLRP3 inflammatory pathway, and elevated proinflammatory cytokines of IL-18 and IL-1β in a dose-dependent manner. Notably, we next utilized previously reported pharmacological inhibitors or siRNA for HMGB1 and found that they significantly inhibited the activation of downstream NLRP3 and MAPK pathways derived from PM2.5 exposure, and down-regul...
Source: Ecotoxicology and Environmental Safety - May 23, 2022 Category: Environmental Health Authors: Chong Liu Yingjie She Jia Huang Yongping Liu Wanwei Li Can Zhang Tianliang Zhang Li Yu Source Type: research
Revealing Potential Diagnostic Gene Biomarkers Associated with Immune Infiltration in Patients with Renal Fibrosis Based on Machine Learning Analysis
In this study, we identified 24 DEGs. The result of LASSO and SVM-RFE identified nine critical genes. ROC assays confirmed the diagnostic value of the above nine genes for renal fibrosis. Immune cell infiltration analysis revealed that ISG20 and SERPINA3 were both found to be correlated with T cell follicular helper, neutrophils, T cell CD4 memory activated, eosinophils, T cell CD8, dendritic cell activated, B cell memory, monocytes, macrophage M2, plasma cells, T cell CD4 naïve, mast cell resting, B cell naïve, T cell regulatory, and NK cell activated. Finally, we observed that the expression of ISG20 and SERPINA3 was d...
Source: Journal of Immunology Research - May 2, 2022 Category: Allergy & Immunology Authors: Yu-Chao Sun Zhen-Zhen Qiu Fu-Li Wen Jin-Quan Yin Hao Zhou Source Type: research
Electroacupuncture at Zusanli ameliorates the autistic-like behaviors of rats through activating the Nrf2-mediated antioxidant responses
CONCLUSION: These data suggested that electroacupuncture at ST36 protected nerve function in ASD rats through Nrf2 activation and the antioxidant response.PMID:35339642 | DOI:10.1016/j.gene.2022.146440
Source: Gene - March 27, 2022 Category: Genetics & Stem Cells Authors: Yong-Hong Zhao Hong-Guang Fu Hui Cheng Rui-Juan Zheng Guo Wang Sheng Li En-Yao Li Li-Guo Li Source Type: research
CFIm-mediated alternative polyadenylation remodels cellular signaling and miRNA biogenesis
We describe the elicited signaling pathways downstream of CFIm, which improve our understanding of the key role of CFIm in integrating RNA processing with other cellular activities.PMID:35234914 | DOI:10.1093/nar/gkac114
Source: Cell Research - March 2, 2022 Category: Cytology Authors: Souvik Ghosh Meric Ataman Maciej Bak Anastasiya B örsch Alexander Schmidt Katarzyna Buczak Georges Martin Beatrice Dimitriades Christina J Herrmann Alexander Kanitz Mihaela Zavolan Source Type: research
Genes, Vol. 13, Pages 319: The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects
In this study, we investigated the most responsible region for the off-target effect by conducting a comprehensive analysis of the thermodynamic properties of all possible siRNA subregions that involved a machine learning technique using a random sampling procedure. As a result, the thermodynamic stability of nucleotides 2&ndash;5 showed the highest positive correlation with the off-target effect, and nucleotides 8&ndash;14 showed the most negative correlation. Thus, it is revealed that the siRNA off-target effect is determined by the base-pairing stabilities of two different subregions with opposite effects.
Source: Genes - February 9, 2022 Category: Genetics & Stem Cells Authors: Yoshiaki Kobayashi Shen Tian Kumiko Ui-Tei Tags: Article Source Type: research
Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells
ConclusionsWe show that time-dependent changes induced by suppression of oncogenicEWSR1/FLI1 expression induces dormancy, with different subpopulation dynamics. Cells re-entering the proliferative cycle show enhanced stem-like characteristics, whereas those remaining dormant for prolonged periods appear to survive through autophagy. Cells with these characteristics identified in exponentially growing cell populations and in tumor xenografts may confer drug resistance and could potentially contribute to metastasis.
Source: Cellular Oncology - January 7, 2022 Category: Cancer & Oncology Source Type: research
GSE180248 Transcriptomic analysis of HDAC6-selective and broad HDAC inhibitors in human WT iPSC cardiomyocytes
Contributors : Jin Yang ; Francis Grafton ; Ana Budan ; Sara Ranjbarvaziri ; Farshad Farshidfar ; Marie Cho ; Emma Xu ; Jaclyn Ho ; Mahnaz Maddah ; Kevin E Loewke ; Julio Medina ; David Sperandio ; Snahel Patel ; Tim Hoey ; Mohammad A MandegarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying molecular mechanisms associated with genetic forms...
Source: GEO: Gene Expression Omnibus - December 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE179656 Phenotypic Screening with Deep Learning Identifies HDAC6 Inhibitors as Cardioprotective Agents in Mouse Models of Dilated Cardiomyopathy
Contributors : Jin Yang ; Francis Grafton ; Ana Budan ; Sara Ranjbarvaziri ; Farshad Farshidfar ; Marie Cho ; Emma Xu ; Jaclyn Ho ; Mahnaz Maddah ; Kevin E Loewke ; Julio Medina ; David Sperandio ; Snahel Patel ; Tim Hoey ; Mohammad A MandegarSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDilated cardiomyopathy (DCM) is characterized by reduced cardiac output, as well as thinning and enlargement of left ventricular chambers. These characteristics eventually lead to heart failure. Current standards of care do not target the underlying molecular mechanisms associated with genetic forms...
Source: GEO: Gene Expression Omnibus - December 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
APP palmitoylation is involved in the increase in A β < sub > 1-42 < /sub > induced by aluminum
In this study, APP palmitoylation was studied in the setting of aluminum-induced increases in Aβ1-42 from two perspectives: whole animal experiments and in vitro cell experiments. First, the learning and memory of rats were impaired and the number of rat cortical neurons was decreased after staining with aluminum. Second, the expression of palmitoyl APP, APP in lipid rafts and palmitoyl acyltransferase zDHHC7 both in rat cerebral cortex and PC12 cells increased with the production of Aβ1-42 induced by aluminum in a dose-dependent manner. Finally, the intervention with the palmitoylation inhibitors 2-BP and siRNA zDHHC7 i...
Source: Cell Research - November 10, 2021 Category: Cytology Authors: Jing Song Chunman Yuan Wenjing Li Ting Gao Xiaoting Lu Linping Wang Source Type: research
