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Focal Scn1a knockdown induces cognitive impairment without seizures.
Abstract Cognitive impairment is a common comorbidity in pediatric epilepsy that can severely affect quality of life. In many cases, antiepileptic treatments fail to improve cognition. Therefore, a fundamental question is whether underlying brain abnormalities may contribute to cognitive impairment through mechanisms independent of seizures. Here, we examined the possible effects on cognition of Na(v)1.1 down-regulation, a sodium channel principally involved in Dravet syndrome but also implicated in other cognitive disorders, including autism and Alzheimer's disease. Using an siRNA approach to knockdown Na(v)1.1 s...
Source: Neurobiology of Disease - January 11, 2013 Category: Neurology Authors: Bender AC, Natola H, Holmes GL, Scott RC, Lenck-Santini PP Tags: Neurobiol Dis Source Type: research

Reconsideration of in silico siRNA design from a perspective of heterogeneous data integration: problems and solutions.
Abstract The success of RNA interference (RNAi) depends on the interaction between short interference RNAs (siRNAs) and mRNAs. Design of highly efficient and specific siRNAs has become a challenging issue in applications of RNAi. Here, we present a detailed survey on the state-of-the-art siRNAs design, focusing on several key issues with the current in silico RNAi studies, including: (i) inconsistencies among the proposed guidelines for siRNAs design and the incomplete list of siRNAs features, (ii) improper integration of the heterogeneous cross-platform siRNAs data, (iii) inadequate consideration of the binding s...
Source: Briefings in Bioinformatics - December 29, 2012 Category: Bioinformatics Authors: Liu Q, Zhou H, Zhu R, Xu Y, Cao Z Tags: Brief Bioinform Source Type: research

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