Filtered By:
Condition: Benign Prostatic Hyperplasia

This page shows you your search results in order of date. This is page number 8.

Order by Relevance | Date

Total 117 results found since Jan 2013.

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
This study supports an oncogenic role for CYP1A1 in prostate cancer via promoter hypomethylation that is influenced by tobacco smoking, indicating CYP1A1 to be a promising target for prostate cancer treatment. PMID: 27203547 [PubMed - as supplied by publisher]
Source: Oncotarget - May 21, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

SATB1 promotes prostate cancer metastasis by the regulation of epithelial-mesenchymal transition.
In this study SATB1 expression vector or siRNA was employed to modulate the expression level of SATB1 in prostate cancer cells and xenograft tumor in nude mouse model. Immunohistochemical analysis was performed on clinical prostate cancer samples. Silencing SATB1 inhibited the growth of DU-145 cells subcutaneous tumor in nude mice, while SATB1 overexpression promoted the growth of LNCaP cells subcutaneous tumor in nude mice. Immunohistochemical and Western blot analysis of the xenografts showed that silencing SATB1 led to decreased expression of vimentin and MMP2 and increased expression of E-cadherin, while SATB1 overexpr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2016 Category: Drugs & Pharmacology Authors: Mao LJ, Yang CH, Fan L, Gao P, Yang DR, Xue BX, Zheng JN, Shan YX Tags: Biomed Pharmacother Source Type: research

SATB1 promotes prostate cancer metastasis by the regulation of epithelial–mesenchymal transition
In this study SATB1 expression vector or siRNA was employed to modulate the expression level of SATB1 in prostate cancer cells and xenograft tumor in nude mouse model. Immunohistochemical analysis was performed on clinical prostate cancer samples. Silencing SATB1 inhibited the growth of DU-145 cells subcutaneous tumor in nude mice, while SATB1 overexpression promoted the growth of LNCaP cells subcutaneous tumor in nude mice. Immunohistochemical and Western blot analysis of the xenografts showed that silencing SATB1 led to decreased expression of vimentin and MMP2 and increased expression of E-cadherin, while SATB1 overexpr...
Source: Biomedicine and Pharmacotherapy - February 11, 2016 Category: Drugs & Pharmacology Source Type: research

Abstract A16: Different epigenetic mechanisms involved in the regulation of SFRP1 gene in prostate cancer
Among men, prostate cancer (PCa)[1] is the second most common cancer and the fifth cause of death worldwide [2]. Androgens play an important role in the development of the disease. For advanced PCa the standard therapy is androgen depletion. However, after 2 or 3 years a high percentage of patients become resistant to this therapy and castration resistant prostate cancer (CRPC) is developed. There is no successful treatment for CRPC, leading into death [3, 4]. Wingless pathway (WNT) is aberrantly activated in several cancer types and in PCa it is involved in AR activity modulation, promoting cancer development [5]. Secrete...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Garcia–Tobilla, P., Uribe, O., Rodriguez–Dorantes, M. Tags: Epigenetic Control of Transcription/ Elongation Source Type: research

27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells
In this study, we determined the effect of 27-OHC in human prostate epithelial cells RWPE-1. We found that 27-OHC stimulates proliferation and increases androgen receptor (AR) transcriptional activity. 27-OHC also increased prostate-specific antigen expression and enhanced AR binding to the androgen response element compared to controls. Silencing AR expression with siRNA markedly reduced the 27-OHC-induced proliferation. Furthermore, 27-OHC blocked docetaxel-induced apoptosis. Altogether, our results suggest that 27-OHC may play an important role in PCa and BPH progression by promoting proliferation and suppressing apoptosis.
Source: Medical Oncology - January 5, 2016 Category: Cancer & Oncology Source Type: research

Inhibition of LDHA suppresses tumor progression in prostate cancer
Abstract A key hallmark of cancer cells is their altered metabolism, known as Warburg effect. Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tumor progression. However, the function of LDHA in prostate cancer has not been studied. In current study, we observed overexpression of LDHA in the clinical prostate cancer samples compared with benign prostate hyperplasia tissues as demonstrated by immunohistochemistry and real-time qPCR. Attenuated expression of LDHA by siRNA or inhibition of LDHA activities by FX11 inhibited cell proliferation, mig...
Source: Tumor Biology - May 16, 2015 Category: Cancer & Oncology Source Type: research

Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation
Conclusions: We demonstrate a cross-talk between alpha1D-AR and TRPV1, that is involved in the control of PC3 cell proliferation. These data strongly support for a putative novel pharmacological approach in the treatment of PCa by targeting both alpha1D-AR and TRPV1 channels.
Source: BMC Cancer - December 7, 2014 Category: Cancer & Oncology Authors: Maria MorelliConsuelo AmantiniMassimo NabissiSonia LiberatiClaudio CardinaliValerio FarfarielloDaniele TomassoniWilma QuagliaAlessandro PiergentiliAlessandro BonifaziFabio Del BelloMatteo SantoniGabriele MammanaLucilla ServiAlessandra FilosaAngela Gismond Source Type: research

Potential role of the OPG/RANK/RANKL axis in prostate cancer invasion and bone metastasis.
Authors: Li X, Liu Y, Wu B, Dong Z, Wang Y, Lu J, Shi P, Bai W, Wang Z Abstract Receptor activator of NF-κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) are key regulators of bone metabolism under both normal and pathological conditions, including prostate cancer (PCa) bone metastases. However, little is known concerning the expression and function of these regulators in prostate tumor samples and PCa cells and their correlation with invasion and bone metastasis. In the present study, we determined the expression of RANK, RANKL and OPG in 3 human PCa cell lines and 40 PCa patient samples by immunohistoche...
Source: Oncology Reports - November 16, 2014 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion.
Abstract SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer (PCa) tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis in vitro. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) were used to detect the expression of SETDB1 in PCa tissues, adjacent normal tissues, benign prostatic hyperplasia (BPH) tissues, PCa cell lines and normal prostate epithelial cells. The results suggested that SETDB1 was upregulated in human PC...
Source: Asian Journal of Andrology - February 18, 2014 Category: Urology & Nephrology Authors: Sun Y, Wei M, Ren SC, Chen R, Xu WD, Wang FB, Lu J, Shen J, Yu YW, Hou JG, Xu CL, Huang JT, Sun YH Tags: Asian J Androl Source Type: research

The over‐expression of Pim‐2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B
CONCLUSIONPim‐2 was over‐expressed in PCA cell lines and tissues. It may inhibit the apoptosis of PCA cells through phosphorylating eIF4B, thus promote the tumorigenesis of PCA. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 27, 2013 Category: Urology & Nephrology Authors: Ke Ren, Xin Gou, Mingzhao Xiao, Ming Wang, Chaodong Liu, Zhaobing Tang, Weiyang He Tags: Original Article Source Type: research

Knockdown of the co‐chaperone SGTA results in the suppression of androgen and PI3K/AKT signaling and inhibition of prostate cancer cell proliferation
This study provides insight into the biological actions of SGTA, its effect on genome‐wide AR transcriptional activity and other therapeutically targeted intracellular signaling pathways, whilst also providing evidence for PCa‐specific alterations in SGTA expression. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - June 6, 2013 Category: Cancer & Oncology Authors: Andrew P. Trotta, Eleanor F. Need, Luke A. Selth, Samarth Chopra, Carole B. Pinnock, Damien A. Leach, Gerhard A Coetzee, Lisa M. Butler, Wayne D. Tilley, Grant Buchanan Tags: Cancer Cell Biology Source Type: research

The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor
Conclusions: Our study suggests reciprocal regulation of PlncRNA-1 and androgen receptor contribute to CaP pathogenesis and that PlncRNA-1 is a potential therapy target.
Source: Urologic Oncology: Seminars and Original Investigations - January 24, 2012 Category: Urology & Nephrology Authors: Zilian Cui, Shancheng Ren, Ji Lu, Fubo Wang, Weidong Xu, Yi Sun, Min Wei, Junyi Chen, Xu Gao, Chuanliang Xu, Jian-Hua Mao, Yinghao Sun Tags: Laboratory - Prostate Source Type: research