Knockdown of the co‐chaperone SGTA results in the suppression of androgen and PI3K/AKT signaling and inhibition of prostate cancer cell proliferation

This study provides insight into the biological actions of SGTA, its effect on genome‐wide AR transcriptional activity and other therapeutically targeted intracellular signaling pathways, whilst also providing evidence for PCa‐specific alterations in SGTA expression. © 2013 Wiley Periodicals, Inc.

Source: International Journal of Cancer - June 6, 2013 Category: Cancer & Oncology Authors: Andrew P. Trotta, Eleanor F. Need, Luke A. Selth, Samarth Chopra, Carole B. Pinnock, Damien A. Leach, Gerhard A Coetzee, Lisa M. Butler, Wayne D. Tilley, Grant Buchanan Tags: Cancer Cell Biology Source Type: research