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Condition: Atrial Fibrillation

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Total 40 results found since Jan 2013.

Effect of Small Interference RNA on the Acetylcholine-Sensitive Potassium Channel in H9c2 Cells.
CONCLUSION: siRNA could effectively inhibit the IK(ACh) channel and is a potential therapy for atrial fibrillation. PMID: 25696012 [PubMed - as supplied by publisher]
Source: Annals of Clinical and Laboratory Science - January 1, 2015 Category: Laboratory Medicine Authors: He F, Zhao J, Li L, Guo R Tags: Ann Clin Lab Sci Source Type: research

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
Conclusion In summary, this study is the first to combine metabolomics, transcriptomics, and genome-wide association studies in a porcine model. Our results improve understanding of the genetic regulation of metabolites which link to transcripts and finally biochemical-clinical parameters. Further, high-performance profiling of metabolites as intermediate phenotypes is a potentially powerful approach to uncover how genetic variation affects metabolic and health status. Our results advance knowledge in areas of biomedical and agricultural interest and identify potential correlates of biomarkers, SNPs-metabolites, SNPs-tran...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study
Conclusion Knockdown of caspase 3 by atrial Ad-siRNA-Cas3 gene transfer suppresses or delays the onset of persistent AF by reduction in apoptosis and prevention of intra-atrial conduction delay in a porcine model. These results highlight the significance of apoptosis in the pathophysiology of AF and demonstrate short-term efficacy of gene therapy for suppression of AF.
Source: European Heart Journal - January 6, 2013 Category: Cardiology Authors: Trappe, K., Thomas, D., Bikou, O., Kelemen, K., Lugenbiel, P., Voss, F., Becker, R., Katus, H. A., Bauer, A. Tags: BASIC SCIENCE Source Type: research

Bone Morphogenetic Protein-7 Antagonizes Myocardial Fibrosis Induced by Atrial Fibrillation by Restraining Transforming Growth Factor- β (TGF-β)/Smads Signaling.
CONCLUSIONS BMP-7 can regulate TGF-β1/Smad3 by targeting Smad1/5 to antagonize fibrosis in myocardial fibroblasts resulting from atrial fibrillation. PMID: 27677228 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - October 1, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Crosstalk between the activated Slit2 –Robo1 pathway and TGF‐β1 signalling promotes cardiac fibrosis
ConclusionsThe Slit2 –Robo1 signalling pathway interfered with the TGF‐β1/Smad pathway and promoted cardiac fibrosis. Blockade of Slit2–Robo1 might be a new treatment for cardiac fibrosis.
Source: ESC Heart Failure - November 24, 2020 Category: Cardiology Authors: Yunqi Liu, Ziwei Yin, Xueqin Xu, Chen Liu, Xiaoying Duan, Qinlan Song, Ying Tuo, Cuiping Wang, Jing Yang, Shengli Yin Tags: Original Research Article Source Type: research

Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers
Conclusion: Disruption of cilia formation by siIft88 causes ECM remodeling and conduction abnormalities. Prevention of cilia loss could be a target for prevention of arrhythmias.
Source: Frontiers in Physiology - November 17, 2022 Category: Physiology Source Type: research

Eplerenone Prevents Atrial Fibrosis via the TGF- β Signaling Pathway
Conclusions: EPL inhibited atrial fibrosis in Tx mice. The underlying mechanism may involve increased protein expression of Smad7, which enhances the inhibitory feedback regulation of TGF- β1/Smad signaling.Cardiology 2017;138:55-62
Source: Cardiology - June 1, 2017 Category: Cardiology Source Type: research

An Inhibitor of Activated Blood Coagulation Factor X Shows Anti-Endothelial Senescence and Anti-Atherosclerotic Effects
Conclusion: Rivaroxaban prevents replicative senescence in HUVECs and aortic endothelial cells in dyslipidemic diabetic mice. It restores endothelial function and prevents the progression of atherosclerosis.J Vasc Res
Source: Journal of Vascular Research - July 2, 2019 Category: Research Source Type: research

Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR- γ/PGC-1α Signaling Pathway
Conclusion: Diabetes mellitus induces adverse atrial structural, electrophysiological remodeling, and mitochondrial damage and dysfunction. Pioglitazone prevented these abnormalities through the PPAR-γ/PGC-1α pathway.
Source: Frontiers in Pharmacology - June 14, 2021 Category: Drugs & Pharmacology Source Type: research

Effect of Sox9 on TGF- β1-mediated atrial fibrosis
In conclusion, Sox9 is involved in the regulation of fibrosis in the atria and may be located downstream of TGF-β1. Our findings may provide a new perspective to treat atrial fibrosis during AF.PMID:34596216 | DOI:10.1093/abbs/gmab132
Source: Acta Biochimica et Biophysica Sinica - October 1, 2021 Category: Biochemistry Authors: Hechuan Wang Yiqi Chen Shuting Zhao Xiaowen Wang Kai Lu Hua Xiao Source Type: research

Beneficial Effect of Edoxaban on Preventing Atrial Fibrillation and Coagulation by Reducing Inflammation via HBG1/HBD Biomarkers
Conclusion: Edoxaban could prevent atrial fibrillation and coagulation by reducing inflammation, lipids, and fibrosis via HBG1/HBD biomarkers effectively, and the effect was superior to that of rivaroxaban.
Source: Frontiers in Pharmacology - June 3, 2022 Category: Drugs & Pharmacology Source Type: research

TRIF Promotes Angiotensin II-Induced Cross-talk between Fibroblasts and Macrophages in Atrial Fibrosis.
CONCLUSIONS: Our data demonstrated that TRIF may be a crucial factor promoting the interaction between atrial fibroblasts and macrophages, leading to atrial fibrosis. PMID: 26056004 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - June 5, 2015 Category: Biochemistry Authors: Chen XQ, Zhang DL, Zhang MJ, Guo M, Zhan YY, Liu F, Jiang WF, Zhou L, Zhao L, Wang QX, Liu X Tags: Biochem Biophys Res Commun Source Type: research

PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression Original Articles
Conclusions— PANCR and PITX2c are coordinately expressed early during cardiomyocyte differentiation from stem cells. PANCR knockdown decreased PITX2c expression in differentiated cardiomyocytes, altering the transcriptome in a manner similar to PITX2c knockdown.
Source: Circulation: Arrhythmia and Electrophysiology - January 18, 2016 Category: Cardiology Authors: Gore-Panter, S. R., Hsu, J., Barnard, J., Moravec, C. S., Van Wagoner, D. R., Chung, M. K., Smith, J. D. Tags: Arrhythmias, Atrial Fibrillation, Gene Expression & Regulation, Functional Genomics Original Articles Source Type: research