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Cancer: Glioma
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Total 16 results found since Jan 2013.
FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy
ConclusionOur findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 11, 2022 Category: Research Source Type: research
The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma
CONCLUSIONS: Our results show for the first time that the expression of the TAC1R gene (NK-1R) is essential for the viability of GAMG and U-87 MG glioma cells. On the contrary, the TAC1R gene is not essential for the viability of normal cells, confirming that NK-1R could be a promising and specific therapeutic target for the treatment of glioma.PMID:35434136 | PMC:PMC9006081 | DOI:10.1155/2022/6291504
Source: Biomed Res - April 18, 2022 Category: Research Authors: Mario F Mu ñoz Sandro Arg üelles Marisa Rosso Rafael Medina Rafael Cove ñas Antonio Ayala Miguel Mu ñoz Source Type: research
Silencing of Long Non-Coding RNA (LncRNA) Non-Coding RNA Activated by DNA Damage (NORAD) Inhibits Proliferation, Invasion, Migration, and Promotes Apoptosis of Glioma Cells via Downregulating the Expression of AKR1B1.
CONCLUSIONS These findings demonstrated that NORAD silencing suppressed proliferation, invasion, and migration and boosted apoptosis of glioma cells via downregulating the AKR1B1 expression, which may provide a potential therapeutic target for glioma treatment.
PMID: 32778640 [PubMed - in process]
Source: Medical Science Monitor - August 13, 2020 Category: Research Tags: Med Sci Monit Source Type: research
Long Noncoding RNASBF2-AS1 Promotes Gastric Cancer Progression via Regulating miR-545/EMS1 Axis.
Conclusion: These findings elucidated a crucial role of SBF2-AS1 as a miR-545 sponge in GC cells, suggesting that SBF2-AS1 might be a potential target for GC.
PMID: 32626753 [PubMed - in process]
Source: Biomed Res - July 8, 2020 Category: Research Authors: He M, Feng L, Qi L, Rao M, Zhu Y Tags: Biomed Res Int Source Type: research
Phytanoyl-CoA 2-Hydroxylase-Interacting Protein-Like Gene Is a Therapeutic Target Gene for Glioblastoma Multiforme.
This study searched for significant genes and the mechanisms involved in GBM. We used the Gene Expression Omnibus (GEO) to test the WHO normal and IV glioma database, used R tool to identify the significant gene, and finally, combined these with The Cancer Genome Atlas (TCGA) to verify the significant genes. Subsequently, we explored the biological mechanisms involved. Phytanoyl-CoA 2-hydroxylase-interacting protein-like gene (PHYHIPL) is downregulated in grade IV glioma (GBM). The downregulation of PHYHIPL in GBM is accompanied by poor overall survival in the TCGA database, which indicates that PHYHIPL is a protection gen...
Source: Medical Science Monitor - April 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research
miR-126 Suppresses Invasion and Migration of Malignant Glioma by Targeting Mature T Cell Proliferation 1 (MTCP1).
CONCLUSIONS miR-126 inhibits the migration of malignant glioma cells by inhibiting MTCP1.
PMID: 30233082 [PubMed - in process]
Source: Medical Science Monitor - September 22, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Silencing of telomere-binding protein adrenocortical dysplasia homolog (ACD) enhances radiosensitivity in glioblastoma cells
This study investigated the expression profile of ACD in human gliomas and its role in radioresistance of glioma cells. The expression of ACD was analyzed in sixty-two different grade of glioma tissues and correlated with prognosis. A radioresistant cell line was generated from U87MG cells. For mechanistic studies, ACD was inhibited by small interfering RNA (siRNA) targeting ACD and the effect on cell radioresistance, telomerase activity, cyclinD1, caspase-3, hTERT, and BIRC1 was evaluated.
Source: Translational Research - July 19, 2018 Category: Research Authors: Francesca Polito, Maria Cucinotta, Rosaria V. Abbritti, Anna Brogna, Stefano Pergolizzi, Chiara Tomasello, Flavio F. Angileri, Rosa Maria Di Giorgio, Alfredo Conti, Domenico La Torre, Antonino German ò, M'hammed Aguennouz Source Type: research
IL-6 increases SDCBP expression, cell proliferation, and cell invasion by activating JAK2/STAT3 in human glioma cells.
Authors: Cao F, Zhang Q, Chen W, Han C, He Y, Ran Q, Yao S
Abstract
Syndecan-binding protein (SDCBP), which is induced by tumor necrosis factor-α and interferon-γ, controls the proliferation and invasion of several different types of cancer cells. Interleukin-6 (IL-6) is known to play an important role in the glioma cell growth and invasion. The present study aimed to investigate the relationship between IL-6 and SDCBP in glioma cells. SDCBP expression was knocked down in two glioma cell lines (T98G and U87) by small interfering RNA (siRNA) transfection. Cell proliferation and invasion were significantly represse...
Source: American Journal of Translational Research - November 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research
Expression of G Protein-coupled Receptor 56 Is an Unfavorable Prognostic Factor in Osteosarcoma Patients.
This study aimed at figuring out whether expression of the GPR56 was associated with clinicopathological features of osteosarcoma. Eighty-nine patients who received osteosarcoma operation between March 2004 and February 2011 in Linyi People's Hospital were recruited. Immunohistochemical staining (IHC) was carried out to identify the expression of GPR56 in those osteosarcoma tissues, and our cohort was divided into higher-expression group and lower-expression group according to the cut-off of IHC score. Expression of GPR56 in osteosarcoma tissues was correlated with the TNM stage and overall survival. Univariate and multiva...
Source: The Tohoku Journal of Experimental Medicine - July 13, 2016 Category: Research Authors: Chen Z, Gao P, Li Z Tags: Tohoku J Exp Med Source Type: research
Expression of Tim4 in Glioma and its Regulatory Role in LN-18 Glioma Cells.
CONCLUSIONS The expression level of Tim-4 is closely associated with glioma. Decreased expression of Tim4 inhibited the growth and colony-forming ability of LN-18 cells and induced their apoptosis, whereas increased expression of Tim4 stimulated the growth and clonogenic potential of LN-18 cells and suppressed their apoptosis.
PMID: 26741116 [PubMed - in process]
Source: Medical Science Monitor - January 13, 2016 Category: Research Tags: Med Sci Monit Source Type: research
MiRNA-323-5p Promotes U373 Cell Apoptosis by Reducing IGF-1R.
CONCLUSIONS MiRNA-323-5p inhibited human cerebral glioma U373 cell proliferation and promoted its apoptosis by reducing IGF-1R.
PMID: 26656446 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - December 18, 2015 Category: Research Tags: Med Sci Monit Source Type: research
Silencing of bmi-1 gene enhances chemotherapy sensitivity in human glioblastoma cells.
CONCLUSIONS There is a notable relationship between the over-expression of BMI1 and the carcinogenesis of gliomas. The silence of BMI1 inhibited cell proliferation and enhanced the apoptosis of the U251 cells, and increased the chemotherapy sensitivity of U251 cells to DDP.
PMID: 25858624 [PubMed - in process]
Source: Medical Science Monitor - April 12, 2015 Category: Research Tags: Med Sci Monit Source Type: research
Drosophila oncogene Gas41 is RNAi modulator that intersects heterochromatin and siRNA pathway
Abstract
Glioma amplified sequence41 (Gas41) is a highly conserved putative transcription factor that is frequently abundant in human gliomas. Gas41 shows oncogenic activity by promoting cell growth and viability. Here we show Gas41 is required for proper functioning of RNAi machinery in the nuclei, though three basic structural domains of RNAi components PAZ, PIWI and dsRNA binding are absent in the structural sequences. Variations of structural domains are highly conversed among prokaryotes and eukaryotes. Gas41 interacts with cytological RNase III enzyme Dicer1 both biochemically and genetically. However, Drosophila Gas...
Source: FEBS Journal - October 16, 2014 Category: Research Authors: Sumit G. Gandhi, Indira Bag, Saswati Sengupta, Manika Pal‐Bhadra, Utpal Bhadra Tags: Original Article Source Type: research
Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy
Conclusions:
These results suggest that anti-VEGF treatment promotes glioma cell invasion via activation of Pyk2 . Inhibition of Pyk2 phosphorylation might be a potential target to ameliorate the therapeutic efficiency of anti-VEGF treatment.
Source: Journal of Translational Medicine - May 27, 2014 Category: Research Authors: Cheng-Shi XuZe-Fen WangLi-Ming DaiSheng-Hua ChuLing-Ling GongMing-Huan YangZhi-Qiang Li Source Type: research
