Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy

Conclusions:
These results suggest that anti-VEGF treatment promotes glioma cell invasion via activation of Pyk2 . Inhibition of Pyk2 phosphorylation might be a potential target to ameliorate the therapeutic efficiency of anti-VEGF treatment.

Source: Journal of Translational Medicine - May 27, 2014 Category: Research Authors: Cheng-Shi XuZe-Fen WangLi-Ming DaiSheng-Hua ChuLing-Ling GongMing-Huan YangZhi-Qiang Li Source Type: research