Silencing of telomere-binding protein adrenocortical dysplasia homolog (ACD) enhances radiosensitivity in glioblastoma cells

This study investigated the expression profile of ACD in human gliomas and its role in radioresistance of glioma cells. The expression of ACD was analyzed in sixty-two different grade of glioma tissues and correlated with prognosis. A radioresistant cell line was generated from U87MG cells. For mechanistic studies, ACD was inhibited by small interfering RNA (siRNA) targeting ACD and the effect on cell radioresistance, telomerase activity, cyclinD1, caspase-3, hTERT, and BIRC1 was evaluated.

Source: Translational Research - July 19, 2018 Category: Research Authors: Francesca Polito, Maria Cucinotta, Rosaria V. Abbritti, Anna Brogna, Stefano Pergolizzi, Chiara Tomasello, Flavio F. Angileri, Rosa Maria Di Giorgio, Alfredo Conti, Domenico La Torre, Antonino German ò, M'hammed Aguennouz Source Type: research