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Cancer: Squamous Cell Carcinoma

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Total 783 results found since Jan 2013.

Identification and function of circular RNA hsa_circ_0071106: A novel biomarker for differentiation degree of esophageal squamous cell carcinoma
CONCLUSION: Hsa_circ_0071106 was a downregulated circRNA related to ESCC and promoted ESCC progression by regulating cell migration and invasion. These findings suggest that hsa_circ_0071106 could be a promising diagnostic biomarker and potential therapeutic target and might predict ESCC's histological differentiation degree.PMID:35390631 | DOI:10.1016/j.prp.2022.153875
Source: Pathology, Research and Practice - April 7, 2022 Category: Pathology Authors: Ying Tang Zhikui Gao Ran Liu Source Type: research

MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma
This study aimed to elucidate its expression pattern and functional roles as well as clinical significance in HNSCC. The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and immunohistochemistry (IHC) were utilized to determine the MMP1 expression pattern and the associations between its expression and patients' outcome in HNSCC. Mice tongue squamous cell carcinoma model induced by 4-nitroquinoline 1-oxide (4NQO) and siRNA-mediated cellular assay in vitro were utilized to evaluate the oncogenic role of MMP1. The biological functions and cancer-related pathways involved in MMP1-related genes were found through bio...
Source: Computational and Mathematical Methods in Medicine - September 15, 2022 Category: Statistics Authors: Wei Zhang Xinghong Huang Rong Huang Hong Zhu Pu Ye Xuyang Lin Shuangyue Zhang Meng Wu Feng Jiang Source Type: research

LIF Inhibits Proliferation of Esophageal Squamous Carcinoma Cells by Radiation Mediated Through JAK-STAT Signaling Pathway
Conclusion: The findings of this study reveal that Carbon ion knockdown was shown to downregulate LIF in ESCC cells. LIF is involved in ESCC proliferation and inhibited the ESCC cell proliferation by activating the STAT3 signaling pathways.PMID:37057285 | PMC:PMC10088534 | DOI:10.7150/jca.81222
Source: Cancer Control - April 14, 2023 Category: Cancer & Oncology Authors: Hongtao Luo Zhen Yang Qiuning Zhang Tingdong Li Ruifeng Liu Shuangwu Feng Zhiqiang Liu Shilong Sun Junru Chen Xiaohu Wang Xiaoling Xie Source Type: research

EPHB4 Biomarker in Esophageal Cancers
Esophageal cancer incidence is increasing and has few treatment options. In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines and primary tumor tissues. In total, 94 squamous cell carcinoma, 82 adenocarcinoma, 25 dysplasia, 13 Barrett esophagus, and 25 adjacent or unrelated normal esophageal tissues were evaluated by immunohistochemistry. EPHB4 expression was significantly higher in all the different histologic categories than in adjacent normal tissues. In 13 esophageal cancer cell lines, 3 of the 9 SCC cell lines and 2 of the 4 adeno...
Source: Cancer Research - January 2, 2013 Category: Cancer & Oncology Authors: Hasina, R., Mollberg, N., Kawada, I., Mutreja, K., Kanade, G., Yala, S., Surati, M., Liu, R., Li, X., Zhou, Y., Ferguson, B. D., Nallasura, V., Cohen, K. S., Hyjek, E., Mueller, J., Kanteti, R., El Hashani, E., Kane, D., Shimada, Y., Lingen, M. W., Husain Tags: Molecular and Cellular Pathobiology Source Type: research

Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation.
CONCLUSIONS: Collectively, these data suggest that aberrant differentiation in HNSCC may be attributed to epigenetic dysregulation and suggests that inhibition of PRC2-mediated gene repression may represent a potential therapeutic target. PMID: 23186778 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - November 27, 2012 Category: Cancer & Oncology Authors: Gannon O, Endo-Munoz LB, Merida de Long L, Hazar-Rethinam M, Saunders NA Tags: Clin Cancer Res Source Type: research

Decreased expression of kallikrein‐related peptidase 13: Possible contribution to metastasis of human oral cancer
Abstract The human kallikrein‐related peptidase family is comprised of 15 serine protease genes on chromosome 19q13.4 [1]. Our previous microarray analyses showed that the gene kallikrein‐related peptidase 13 (KLK13) was down‐regulated in oral squamous cell carcinoma (OSCC) cell lines. We evaluated the expression status of KLK13 in primary OSCCs and performed functional molecular experiments in OSCC cell lines. In 102 primary tumors studied, KLK13 expression significantly (P < 0.05) decreased compared with matched normal counterparts. Interestingly, KLK13‐negative cases correlated significantly (P < 0...
Source: Molecular Carcinogenesis - February 1, 2013 Category: Molecular Biology Authors: Shunsaku Ishige, Atsushi Kasamatsu, Kenji Ogoshi, Yasuhiro Saito, Katsuya Usukura, Hidetaka Yokoe, Yukinao Kouzu, Hirofumi Koike, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa Tags: Research Article Source Type: research

Expression profile of drosomycin-like defensin in oral epithelium and oral carcinoma cell lines
Conclusion: DLD may be partially involved in the defence against filamentous fungal infection in the oral mucosa, and may also serve other functions, such as contribution to cell growth.
Source: Archives of Oral Biology - February 11, 2013 Category: Dentistry Authors: Jun Sato, Michiko Nishimura, Mami Yamazaki, Kouki Yoshida, Yoshihito Kurashige, Masato Saitoh, Yoshihiro Abiko Tags: Mucosal Biology Source Type: research

βKlotho regulates the differentiation and tumorgenesis of epidermal keratinocytes
klotho gene is a putative aging suppressor gene. Klotho protein exists in two forms: membrane Klotho and secreted Klotho. The secreted Klotho has been suggested to have anti-oxidative stress/anti-cancer properties partially by inhibiting type I insulin-like growth factor receptor (IGF-IR)/extracellular signal-regulated kinase (ERK) 1/2 activity in some human organs. βKlotho is a member of the Klotho protein family. Immunohistological analysis revealed that the expression of βKlotho protein was reduced in the lesion of human squamous cell carcinoma (SCC) and diminished in the lesion of basal cell carcinoma (BCC) compared ...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Kozo Nakai, Shigeaki Inoue, Reiji Haba, Yoshio Kushida, Nahomi Katsuki, Yoichiro Hosokawa, Tetsuya Moriue, Kozo Yoneda, Yasuo Kubota Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrest.
Abstract Human papilloma virus (HPV) infection represents an emerging risk factor in head and neck squamous cell carcinoma (HNSCC). In contrast to HPV-negative HNSCC, most cases of HPV-positive HNSCC encode wild-type p53, although the p53 protein in these cells is rapidly degraded via HPV E6-mediated ubiquitination and subsequent proteasomal degradation. This unique feature of HPV-positive HNSCC has raised hope that liberation of wild-type p53 from the E6 protein may have therapeutic benefit in this disease. Indeed, suppression of E6 expression promotes apoptosis in HPV-positive HNSCC cell lines. However, the role...
Source: Cell Cycle - February 19, 2013 Category: Cytology Authors: Li C, Johnson DE Tags: Cell Cycle Source Type: research

Strong expression of survivin is associated with positive response to radiotherapy and improved overall survival in Head and Neck squamous cell carcinoma patients
In conclusion, our results suggest that survivin plays an important role in the response to radiotherapy and may be a useful marker for predicting radiotherapy response in patients with HNSCC. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - April 6, 2013 Category: Cancer & Oncology Authors: Lovisa Farnebo, Katharina Tiefenböck, Anna Ansell, Lena K. Thunell, Stina Garvin, Karin Roberg Tags: Cancer Therapy Source Type: research

The role of globular heads of the C1q receptor in HPV 16 E2-induced human cervical squamous carcinoma cell apoptosis is associated with p38 MAPK/JNK activation
Conclusion: These data support a mechanism whereby HPV 16 E2 induces apoptosis by silencing the gC1qR gene or inhibiting p38 MAPK/JNK signalling in cervical squamous cell carcinoma.
Source: Journal of Translational Medicine - May 8, 2013 Category: Research Authors: Ling-juan GaoPing-qing GuWei ZhaoWen-yan DingXue-qing ZhaoShu-yu GuoTian-ying Zhong Source Type: research

HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9.
CONCLUSIONS: These results suggest that the inhibitory effect of TSA on cancer invasion is mediated through the suppression of HDAC2 expression, and that the reduction of MMP-2 and MMP-9 expression induced by HDAC2 may be involved in the anti-invasive effect of TSA. PMID: 23544610 [PubMed - in process]
Source: Clinical and Investigative Medicine - May 22, 2013 Category: Biomedical Science Authors: Wang F, Qi Y, Li X, He W, Fan QX, Zong H Tags: Clin Invest Med Source Type: research

Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition
Abstract: Despite nearly universal expression of the wild-type epidermal growth factor receptor (EGFR) and reproducible activity of EGFR inhibitors in patients with squamous cell carcinoma of the head and neck (SCCHN), the majority of patients will not have objective responses. The mechanisms of this intrinsic resistance are not well established. We hypothesized that sensitivity to EGFR inhibitors can be predicted based on the inhibitors' effects on downstream signaling. Cell viability assays were used to assess sensitivity to the EGFR inhibitor gefitinib (ZD1839) in 8 SCCHN cell lines. Fluorescence in-situ hybridization s...
Source: Molecular Oncology - November 19, 2012 Category: Cancer & Oncology Authors: Natalie R. Young, Jing Liu, Carolyn Pierce, Tai-Fen Wei, Tatyana Grushko, Olufunmilayo I. Olopade, Wanqing Liu, Christine Shen, Tanguy Y. Seiwert, Ezra E.W. Cohen Tags: Papers Source Type: research

Terbinafine Inhibits KSR1 and Suppresses Raf-MEK-ERK signaling in Oral Squamous Cell Carcinoma Cells.
Abstract Terbinafine inhibits the proliferation of many types of cancer cells, but the underlying mechanism remains to be determined. By computer simulation, we found that kinase suppressor of Ras 1 (KSR1) is a possible target of terbinafine. Treatment of human oral squamous cell carcinoma (OSCC) KB cells with either terbinafine or siRNA to knockdown KSR1 reduced proliferation and induced apoptosis, which was accompanied by suppression of the Raf-MEK-ERK pathway. In vivo, KSR1 expression was significantly associated with the clinical staging of OSCC and the smoking habit of patients. Kaplan Meyer survival analys...
Source: Neoplasma - May 24, 2013 Category: Cancer & Oncology Authors: Li B, Lu L, Zhong M, Tan XX, Liu CY, Guo Y, Yi X Tags: Neoplasma Source Type: research