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Cancer: Non-Small Cell Lung Cancer

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Total 1077 results found since Jan 2013.

Targeting HER3-dependent activation of nuclear AKT improves radiotherapy of non-small celllung cancer
CONCLUSION: IR-induced activation of nuclear AKT occurs inside the nucleus that is mainly dependent on HER3 expression in NSCLC. These findings suggest that targeting HER3 in combination with radiotherapy may provide a logical treatment option for investigation in selected NSCLC patients.PMID:35839938 | DOI:10.1016/j.radonc.2022.07.008
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 15, 2022 Category: Radiology Authors: Mahmoud Toulany Mari Iida Konstanze Lettau John P Coan Simone Rebholz Shayan Khozooei Paul M Harari Deric L Wheeler Source Type: research

Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration
In conclusion, this is the first to report the potential function of FAT4 in NSCLC. Hence, FAT4 could be used as a promising prognostic and immunological biomarker for NSCLC.
Source: Cancer Medicine - June 30, 2022 Category: Cancer & Oncology Authors: Yue Ning, Yang Yang, Hongmei Zheng, Yuting Zhan, Hongjing Zang, Qiuyuan Wen, Jinwu Peng, Songqing Fan Tags: RESEARCH ARTICLE Source Type: research

The role of the LINC01234/miR-433-3p/GRB2 ceRNA network in NSCLC cell malignant proliferation
CONCLUSION: LINC01234 competitively bound to miR-433-3p and promoted GRB2 transcription to augment NSCLC cell malignant proliferation.PMID:35747966 | DOI:10.2174/1386207325666220624093957
Source: Combinatorial Chemistry and High Throughput Screening - June 24, 2022 Category: Chemistry Authors: Wei Wei Changyong Wang Jianfeng Zhang Lele Wang Lei Wei Hairong Huang Source Type: research

Circular RNA hsa_circ_0068252 functions in cisplatin resistance and immune response via miR-1304-5p/PD-L1 axis in non-small cell lung cancer
Conclusion: The circ_0068252/miR-1304-5p/PD-L1 signal axis participates in the regulation of DDP resistance and immune escape of NSCLC cells. Our results suggest that circ_0068252 may be a potential diagnostic marker and therapeutic target for DDP-resistant NSCLC.
Source: Chemotherapy - June 1, 2022 Category: Cancer & Oncology Source Type: research

Autophagy regulates transforming growth factor β signaling and receptor trafficking
Biochim Biophys Acta Mol Cell Res. 2022 May 20:119284. doi: 10.1016/j.bbamcr.2022.119284. Online ahead of print.ABSTRACTTransforming growth factor beta (TGFβ) stimulates tumorigenesis by inducing epithelial to mesenchymal transition (EMT) and cell migration. TGFβ signaling is regulated by the endocytosis of cell surface receptors and their subcellular trafficking into the endo-lysosomal system. Here we investigated how autophagy, a cellular quality control network that delivers material to lysosomes, regulates TGFβ signaling pathways that induce EMT and cell migration. We impaired autophagy in non-small cell lung cancer...
Source: Cancer Control - May 23, 2022 Category: Cancer & Oncology Authors: Charles B Trelford Gianni M Di Guglielmo Source Type: research

Cancers, Vol. 14, Pages 2517: NEDD9 Restrains dsDNA Damage Response during Non-Small Cell Lung Cancer (NSCLC) Progression
ander Y. Deneka DNA damaging modalities are the backbone of treatments for non-small cell lung cancer (NSCLC). Alterations in DNA damage response (DDR) in tumor cells commonly contribute to emerging resistance to platinating agents, other targeted therapies, and radiation. The goal of this study is to identify the previously unreported role of NEDD9 scaffolding protein in controlling DDR processes and sensitivity to DNA damaging therapies. Using a siRNA-mediated approach to deplete NEDD9 in a group of human and murine KRAS/TP53-mutant NSCLC cell lines, coupled with a set of cell viability and clonogenic assays, flow cy...
Source: Cancers - May 20, 2022 Category: Cancer & Oncology Authors: Mariya Tikhomirova Iuliia Topchu Aleksandra Mazitova Vitaly Barmin Ekaterina Ratner Alexey Sabirov Zinaida Abramova Alexander Y. Deneka Tags: Article Source Type: research

TROY Modulates Cancer Stem-Like Cell Properties and Gefitinib Resistance Through EMT Signaling in Non –Small Cell Lung Cancer
Targeted therapy has made breakthrough progress in the treatment of advanced non–small cell lung cancer (NSCLC) in the last 20 years. Despite that, acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is an urgent clinical problem. Our study established an acquired gefitinib-resistant cell line, which exhibited epithelial–mesenchymal transition (EMT) and stem cell–like properties. Transcriptional sequencing and bioinformatics analysis revealed that TROY was significantly increased in gefitinib-resistant cells. Gene set enrichment analysis (GSEA) showed EMT was the core enriche...
Source: Frontiers in Genetics - May 13, 2022 Category: Genetics & Stem Cells Source Type: research

Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway
Exp Cell Res. 2022 Apr 26:113179. doi: 10.1016/j.yexcr.2022.113179. Online ahead of print.ABSTRACTRab22a, a member of the proto-oncogene RAS family, belongs to the Rab5 subfamily. It participates in early endosome formation and regulates vesicle trafficking. The relationship between Rab22a and tumorigenesis remains elusive. In non-small cell lung cancer specimens, immunohistochemical staining showed consistently high expression of Rab22a in lung adenocarcinoma, but not in squamous cell carcinoma. In lung adenocarcinoma cell lines, A549 and H1299, transfection with Rab22a significantly promoted cell proliferation, migration...
Source: Experimental Cell Research - April 29, 2022 Category: Cytology Authors: Jinping Wang Xue Luo Jinxi Lu Xi Wang Yuan Miao Qingchang Li Liang Wang Source Type: research

Capmatinib suppresses LPS-induced interaction between HUVECs and THP-1 monocytes through suppression of inflammatory responses
CONCLUSION: These findings imply that CAP improves inflamed endothelial-monocyte adhesion via a PPAR/IL-10-dependent pathway. The current study provides in vitro evidence for a therapeutic approach for treating atherosclerosis.PMID:35483573 | DOI:10.1016/j.bj.2022.04.005
Source: Atherosclerosis - April 28, 2022 Category: Cardiology Authors: Hyung Sub Park A M Abd El-Aty Ji Hoon Jeong Taeseung Lee Tae Woo Jung Source Type: research

LINC00152 knockdown suppresses tumorigenesis in non-small cell lung cancer via sponging miR-16-5p
CONCLUSIONS: The findings of the present study demonstrated that LINC00152-silencing suppressed NSCLC tumorigenesis via regulating the miR-16-5p/BCL2L2 axis. Therefore, linc00152 has the potential as a molecular marker and may be a potential target for the treatment of non-small cell lung cancer.PMID:35399229 | PMC:PMC8987817 | DOI:10.21037/jtd-22-59
Source: Journal of Thoracic Disease - April 11, 2022 Category: Respiratory Medicine Authors: Hang Hu Chen Chen Fugang Chen Naitong Sun Source Type: research