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Cancer: Non-Small Cell Lung Cancer
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Total 1077 results found since Jan 2013.
LINC00152 knockdown suppresses tumorigenesis in non-small cell lung cancer via sponging miR-16-5p
CONCLUSIONS: The findings of the present study demonstrated that LINC00152-silencing suppressed NSCLC tumorigenesis via regulating the miR-16-5p/BCL2L2 axis. Therefore, linc00152 has the potential as a molecular marker and may be a potential target for the treatment of non-small cell lung cancer.PMID:35399229 | PMC:PMC8987817 | DOI:10.21037/jtd-22-59
Source: Journal of Thoracic Disease - April 11, 2022 Category: Respiratory Medicine Authors: Hang Hu Chen Chen Fugang Chen Naitong Sun Source Type: research
Nanog suppression enhanced the chemosensitivity of human non-small-cell lung cancer cells to Cisplatin and inhibited cell migration
In conclusion, the findings of the current study demonstrated that silencing Nanog combined with Cisplatin could be a potent treatment approach for lung cancer patients.PMID:35398618 | DOI:10.1016/j.prp.2022.153869
Source: Pathology, Research and Practice - April 10, 2022 Category: Pathology Authors: Basira Najafzadeh Rouhollah Motafakkerazad Souzan Najafi Mohammad Amini Hajar Alemohammad Parisa Vasefifar Behzad Baradaran Source Type: research
Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study
Oncol Lett. 2022 May;23(5):144. doi: 10.3892/ol.2022.13264. Epub 2022 Mar 11.ABSTRACTNon-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality. Lung adenocarcinoma (LAC) is the most prevalent pathological subtype of NSCLC and accounts for ~40% of all lung cancer mortalities. There remains an urgent demand for the identification of novel biomarkers for the diagnosis and development of therapeutic strategies for LAC. In the present study, the profiles of the differentially-expressed circular RNAs (circRNAs) in LAC tissues compared with those in their corresponding non-cancerous tissues we...
Source: Oncology Letters - March 28, 2022 Category: Cancer & Oncology Authors: Yonggang Zhu Feng Cao Fei Liu Sihua Liu Lingjiao Meng Lina Gu Hanjun Zhao Meixiang Sang Baoen Shan Source Type: research
Hyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy
Drug Deliv. 2022 Dec;29(1):574-587. doi: 10.1080/10717544.2022.2032874.ABSTRACTA novel hyaluronic acid (HA)-modified hybrid nanocomplex HA-SeSe-COOH/siR-93C@PAMAM, which could efficiently deliver siRNA into tumor cells via a redox-mediated intracellular disassembly, was constructed for enhanced antitumor efficacy. Thereinto, siR-93C (siRNA) and positive PAMAM were firstly mixed into the electrostatic nano-intermediate, and then diselenide bond (-SeSe-)-modified HA was coved to shield excessive positive charges. This hybrid nanocomplex displayed uniform dynamic sizes, high stability, controlled zeta potential and narrow PDI...
Source: Drug Delivery - February 14, 2022 Category: Drugs & Pharmacology Authors: Daoyuan Chen Peng Zhang Minghui Li Congcong Li Xiaoyan Lu Yiying Sun Kaoxiang Sun Source Type: research
