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Cancer: Non-Small Cell Lung Cancer
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Total 1077 results found since Jan 2013.
The Biological Role of Lncrna SNHG6 in Non-Small Cell Lung Cancer Cells Via Targeting P21
CONCLUSION: Silencing lncRNA SNHG6 represses the proliferation and facilitates the apoptosis of NSCLC cells through regulating p21.PMID:36933244
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Yongjie Li Dunzhi Fu Wei Sun Qixing Yan Xiaopeng Bu Zhongkai Liao Fu Li Source Type: research
Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway
This study investigated the function and associated mechanism of MMP10 during radiotherapy of NSCLC. MMP10 expression in patients and their overall survival rate were assessed through GEPIA. Protein expression was tested by western blotting. Radioresistance was detected in vitro by apoptosis and clonogenic assay. The extent of DNA damage and repair was revealed by the comet test and γH2AX foci test. High MMP10 levels in specimens of lung adenocarcinoma were related to poor patient outcomes. Clonogenic and apoptosis assays revealed that MMP10 knockdown in A549 cells initiated radiosensitization. Furthermore, MMP10 siRNA in...
Source: Journal of Oncology - March 13, 2023 Category: Cancer & Oncology Authors: Yawei Bi Kun Cao Yuan Wang Wei Yang Na Ma Xiao Lei Yuanyuan Chen Source Type: research
FOXA2 and STAT5A regulate oncogenic activity of KIF5B-RET fusion
Am J Cancer Res. 2023 Feb 15;13(2):638-653. eCollection 2023.ABSTRACTKIF5B-RET gene rearrangement occurs in ~1% of lung adenocarcinomas. Recently, targeted agents that inhibit RET phosphorylation have been evaluated in several clinical studies; however, little is known about the role of this gene fusion in driving lung cancer. Immunohistochemistry was used to evaluate the expression of the FOXA2 protein in tumor tissues of patients with lung adenocarcinoma. KIF5B-RET fusion cells proliferated in a cohesive form and grew tightly packed with variable-sized colonies. The expression of RET and its downstream signaling molecule...
Source: Cell Research - March 10, 2023 Category: Cytology Authors: Mi-Ran Lee Jung-Young Shin Min-Young Kim Jeong-Oh Kim Chan Kwon Jung Jinhyoung Kang Source Type: research
RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy
CONCLUSION: Taken together, RPL11 has a tumor-promoting role in NSCLC. It promotes the cell proliferation of NSCLC cells by regulating ERS and autophagy.PMID:36869281 | DOI:10.1186/s12860-023-00469-2
Source: Cancer Control - March 3, 2023 Category: Cancer & Oncology Authors: Jie Chen Changda Lei Huahua Zhang Xiaoyong Huang Yang Yang Junli Liu Yuna Jia Haiyan Shi Yunqing Zhang Jing Zhang Juan Du Source Type: research
Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly- γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC
Drug Dev Ind Pharm. 2023 Feb 20:1-18. doi: 10.1080/03639045.2023.2182125. Online ahead of print.ABSTRACTDue to the complexity of pathophysiology of non-small cell lung cancer (NSCLC) and susceptibility of single chemotherapy to drug resistance, the combination of drugs and small interfering RNA (siRNA) may produce desired therapeutic effect on NSCLC through action of multiple pathways. We designed to develop poly-γ-glutamic acid-modified cationic liposomes (γ-PGA-CL) to co-deliver pemetrexed disodium (PMX) and siRNA to treat NSCLC. Firstly, γ-PGA was modified on surface of PMX and siRNA co-loaded cationic liposomes by e...
Source: Drug Development and Industrial Pharmacy - February 21, 2023 Category: Drugs & Pharmacology Authors: Huang Xiaoyu Song Ruonan Wang Xiao Kongfang He Rumeng Shan Xie Fei Guihua Huang Source Type: research
Lipopolysaccharide and lipoteichoic acid regulate the PI3K/AKT pathway through osteopontin/integrin β3 to promote malignant progression of non-small cell lung cancer
CONCLUSIONS: This study provides a theoretical basis for further exploration of the influence of lung microbiota on NSCLC and the optimization of LC treatment in the future.PMID:36794132 | PMC:PMC9922606 | DOI:10.21037/jtd-22-1825
Source: Journal of Thoracic Disease - February 16, 2023 Category: Respiratory Medicine Authors: Miao Zhang Yi Sun Yan Zhang Zhen Wang Zhao-Yi Wang Xi-Yue Ming Zhen-Dong Guo Source Type: research
