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Cancer: Non-Small Cell Lung Cancer

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Total 1077 results found since Jan 2013.

Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1
CONCLUSION: Down-regulation of HBXIP reduced Lin28B-mediated NRP-1 to suppress NSCLC cell growth and enhance anti-tumor immunity.PMID:34452886
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Lulu Wang Mao Sun Xing Lin Yongyang Lei Zhe Yin Wei Zhou Source Type: research

Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5
In this study, we identities the epigenetic regulation function of circular RNA circRHOT1 in promoting NSCLC cell proliferation. We found that circRHOT1 were elevated in the clinical tumor tissues relative to that in the peritumor tissues from NSCLC patients. circRHOT1 was up-regulated in human lung cancer cell lines compared with normal human lung epithelial cell line. MTT assays revealed that the silencing of circRHOT1 by siRNA suppressed cell viabilities of NSCLC cells. Colony formation and Edu assays confirmed that circRHOT1 knockdown attenuated NSCLC cell proliferation in vitro. Meanwhile, the depletion of circRHOT1 i...
Source: Aging - August 18, 2021 Category: Biomedical Science Authors: Xiaoyan Ren Jiangang Yu Lili Guo Hong Ma Source Type: research

Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer
Dose Response. 2021 Aug 2;19(3):15593258211033114. doi: 10.1177/15593258211033114. eCollection 2021 Jul-Sep.ABSTRACTNon-small-cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths. Radiotherapy remains the primary treatment method for NSCLC. Despite great advances in radiotherapy techniques and modalities, recurrence and resistance still limit therapeutic success, even low-dose ionizing radiation (IR) can induce the migration and invasion. Diallyl disulfide (DADS), a bioactive component extracted from garlic, exhibits a wide spectrum of biological activities including antitumor effects. However, the eff...
Source: Dose Response - August 16, 2021 Category: Drugs & Pharmacology Authors: Shuai Xu Hefa Huang Deping Tang Mengjie Xing Qiuyue Zhao Jianping Li Jing Si Lu Gan Aihong Mao Hong Zhang Source Type: research

KRAS inhibitor-resistance in MET -amplified KRAS G12C non-small cell lung cancer induced by RAS- and non-RAS-mediated cell signaling mechanisms
CONCLUSIONS: MET amplification leads to the development of resistance to KRAS G12C inhibitors in NSCLC. Dual blockade of MET and KRAS G12C could be a treatment option for MET amplified, KRAS G12C-mutated NSCLC.PMID:34365406 | DOI:10.1158/1078-0432.CCR-21-0856
Source: Clinical Cancer Research - August 8, 2021 Category: Cancer & Oncology Authors: Shinichiro Suzuki Kimio Yonesaka Takeshi Teramura Toshiyuki Takehara Ryoji Kato Hitomi Sakai Koji Haratani Junko Tanizaki Hisato Kawakami Hidetoshi Hayashi Kazuko Sakai Kazuto Nishio Kazuhiko Nakagawa Source Type: research

KRAS inhibitor-resistance in MET-amplified KRAS (G12C) non-small cell lung cancer induced by RAS- and non-RAS-mediated cell signaling mechanisms
CONCLUSIONS: MET amplification leads to the development of resistance to KRAS G12C inhibitors in NSCLC. Dual blockade of MET and KRAS G12C could be a treatment option for MET amplified, KRAS G12C-mutated NSCLC.PMID:34365406 | DOI:10.1158/1078-0432.CCR-21-0856
Source: Clinical Lung Cancer - August 8, 2021 Category: Cancer & Oncology Authors: Shinichiro Suzuki Kimio Yonesaka Takeshi Teramura Toshiyuki Takehara Ryoji Kato Hitomi Sakai Koji Haratani Junko Tanizaki Hisato Kawakami Hidetoshi Hayashi Kazuko Sakai Kazuto Nishio Kazuhiko Nakagawa Source Type: research

KRAS inhibitor-resistance in MET-amplified KRAS (G12C) non-small cell lung cancer induced by RAS- and non-RAS-mediated cell signaling mechanisms
CONCLUSIONS: MET amplification leads to the development of resistance to KRAS G12C inhibitors in NSCLC. Dual blockade of MET and KRAS G12C could be a treatment option for MET amplified, KRAS G12C-mutated NSCLC.PMID:34365406 | DOI:10.1158/1078-0432.CCR-21-0856
Source: Cell Research - August 8, 2021 Category: Cytology Authors: Shinichiro Suzuki Kimio Yonesaka Takeshi Teramura Toshiyuki Takehara Ryoji Kato Hitomi Sakai Koji Haratani Junko Tanizaki Hisato Kawakami Hidetoshi Hayashi Kazuko Sakai Kazuto Nishio Kazuhiko Nakagawa Source Type: research

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