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Cancer: Liver Cancer

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Total 1432 results found since Jan 2013.

Angiotensin II Enhances Proliferation and Inflammation through AT1/PKC/NF-κB Signaling Pathway in Hepatocellular Carcinoma Cells
Conclusions: The results propose that Ang II/AT1/PKC/NF-#x03BA;B signaling pathway is necessary for proliferation and inflammation of HCC cells, which increases our understanding of the pathogenesis and provides clues for developing new strategies against Ang II-related progress of HCC.Cell Physiol Biochem 2016;39:13-32
Source: Cellular Physiology and Biochemistry - June 20, 2016 Category: Cytology Source Type: research

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.
In conclusion, Yap1 post-translational modifications favoring its ubiquitination and apoptosis characterize HCC with better prognosis, whereas conditions favoring the formation of YAP1-TEAD complexes are associated with aggressiveness and acquisition of stemness features by HCC cells. PMID: 27359056 [PubMed - as supplied by publisher]
Source: Oncotarget - July 2, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

HBX Protein-Induced Downregulation of microRNA-18a is Responsible for Upregulation of Connective Tissue Growth Factor in HBV Infection-Associated Hepatocarcinoma.
CONCLUSIONS Our study shows the role of the CTGF gene as a target of miR-18a, and identifies the function of HBV/HBX/miR-18a/CTGF as a key signaling pathway mediating HBV infection-induced HCC. PMID: 27421245 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - July 17, 2016 Category: Research Tags: Med Sci Monit Source Type: research

The anti ‑dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression.
The anti‑dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression. Mol Med Rep. 2016 Jul 13; Authors: Bryan-Marrugo OL, Arellanos-Soto D, Rojas-Martinez A, Barrera-Saldaña H, Ramos-Jimenez J, Vidaltamayo R, Rivas-Estilla AM Abstract Dengue virus (DENV) susceptibility to cholesterol depleting treatments has been previously reported. There are numerous questions regarding how DENV seizes cellular machinery and cholesterol to improve viral production and the effect of cholesterol sequestering agents on the cellular antiviral response. The aim of...
Source: Molecular Medicine Reports - July 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Mcl-1 as a potential therapeutic target for human hepatocelluar carcinoma
Summary Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality in part due to its high resistance to chemotherapeutic drugs. The anti-apoptotic Mcl-1 expression has been reported as a resistance factor in various types of tumors. Here, we investigated the expression of Mcl-1 in hepatoma cells and HCC tissues and its relationship with p53, and analyzed the possibility of the gene as a molecular target for HCC therapy. HCC specimens of 30 patients were examined by immunohistochemistry for Mcl-1 and p53 expression. Mcl-1 expression in hepatoma cell lines was measured by RT-PCR and Western blotting. The s...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 27, 2016 Category: Research Source Type: research

IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells
In this study,IQGAP1 expression was partially silenced in human hepatocellular carcinoma (HepG2) cells. We investigated the impact ofIQGAP1 silencing on the interactions of IQGAP and RAS with several apoptotic proteins, including caspase-3 (CASP3), BCL2-associated X protein (BAX), and B-cell leukemia/lymphoma 2 (BCL2). Additionally, we investigated the effects of the interactions of these genes on cell viability, proliferation, apoptosis, and invasive capacity. IQGAP1 siRNA-treated HepG2 cells showed lower invasive capacity than the control cells, and this reduction was time- and vector concentration-dependent. In addition...
Source: Tumor Biology - August 2, 2016 Category: Cancer & Oncology Source Type: research

Suppression of StarD7 promotes endoplasmic reticulum stress and induces ROS production.
Abstract StarD7 is an intracellular lipid transport protein identified as up-regulated in the choriocarcinoma JEG-3 cell line. StarD7 facilitates the delivery of phosphatidylcholine (PC) to the mitochondria, and StarD7 knockdown causes a reduction in phospholipid synthesis. Since inhibition of PC synthesis may lead to endoplasmic reticulum (ER) stress we hypothesized that StarD7 may be involved in maintaining cell homeostasis. Here, we examined the effect of StarD7 silencing on ER stress response and on the levels of reactive oxygen species (ROS) in the human hepatoma cell line HepG2. StarD7 knockdown induced alte...
Source: Free Radical Biology and Medicine - August 19, 2016 Category: Biology Authors: Flores-Martín J, Reyna L, Ridano ME, Panzetta-Dutari GM, Genti-Raimondi S Tags: Free Radic Biol Med Source Type: research

MicroRNA-126 inhibits tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression.
In conclusion, miR-126 could inhibit tumor proliferation and angiogenesis of HCC by down-regulating EGFL7 expression. PMID: 27611944 [PubMed - as supplied by publisher]
Source: Oncotarget - September 11, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Overexpression of Protein Phosphatase 1 γ (PP1γ) Is Associated with Enhanced Cell Proliferation and Poor Prognosis in Hepatocellular Carcinoma
ConclusionsPP1 γ is upregulated in HCC cell lines and HCC specimens, promotes cancer cell proliferation through regulation of p53, and may be a potential target for treatment of HCC.
Source: Digestive Diseases and Sciences - December 4, 2016 Category: Gastroenterology Source Type: research

Synergisic effect of APRIL knockdown and Jiedu Xiaozheng Yin, a Chinese medicinal recipe, on the inhibition of hepatocellular carcinoma cell proliferation.
In conclusion, these results indicate that APRIL is a target gene for HCC and combination of siRNA-APRIL and JXY application holds great promise as a novel approach for the treatment of APRIL-positive HCC. PMID: 28035399 [PubMed - as supplied by publisher]
Source: Oncology Reports - January 1, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Liposome-mediated RNA interference delivery against Erk1 and Erk2 does not equally promote chemosensitivity in human hepatocellular carcinoma cell line HepG2.
CONCLUSION: Our data show that liposomal siRNA-mediated down-regulation of Erk1/2 can lead to potent chemosensitizing effects in HepG2 cells. Moreover, a higher chemosensitivity following Erk2 down-regulation than Erk1 down-regulation may be associated with the higher expression of Erk2 in human HCC. PMID: 28058860 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - January 7, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Silencing of GP73 inhibits invasion and metastasis via suppression of epithelial-mesenchymal transition in hepatocellular carcinoma.
Authors: Yang Y, Liu Q, Zhang H, Zhao H, Mao R, Li Z, Ya S, Jia C, Bao Y Abstract Epithelial-mesenchymal transition (EMT) is associated with invasion and metastasis of cancer cells. Golgi protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC) and our previous study demonstrated that the expression of GP73 correlated with aggressive behavior and EMT molecules in HCC. However, its role in metastatic mechanism of HCC is not clear. The aim of this study was to investigate the effect of GP73 on invasion and migration, and underlying mechanism of GP73 involved in EMT of HCC. The expression of GP73 was ...
Source: Oncology Reports - January 12, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Effects of LncRNA-HOST2 on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma cell line SMMC-7721.
This study explored the effect of LncRNA-HOST2 on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma (HCC) cell line SMMC-7721. HCC tissues and adjacent normal tissues from 162 HCC patients were collected. The HCC cell lines were assigned into the control group (regular culture), negative control group (NC, transfected with siRNA) and experimental group (transfected with Lnc-HOST2 siRNA). qRT-PCR was used to detect the expression of LncRNA-HOST2. Cell proliferation was detected by CCK-8 and colony-forming assays, cell apoptosis by flow cytometry and cell migration by scratch test. Trans...
Source: Bioscience Reports - January 30, 2017 Category: Biomedical Science Authors: Liu RT, Cao JL, Yan CQ, Wang Y, An CJ, Lv HT Tags: Biosci Rep Source Type: research

Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation
Conclusions: In this study, we found that radiation up-regulated the expression of ATF4. We used ATF4 knockdown and over-expression systems to show that ATF4 may play a role in radiation-induced cellular apoptosis.Cell Physiol Biochem 2017;41:784 –794
Source: Cellular Physiology and Biochemistry - February 10, 2017 Category: Cytology Source Type: research

Corrigendum Loss of Runt ‑related transcription factor 3 induces resistance to 5‑fluorouracil and cisplatin in hepatocellular carcinoma.
[Corrigendum] Loss of Runt‑related transcription factor 3 induces resistance to 5‑fluorouracil and cisplatin in hepatocellular carcinoma. Oncol Rep. 2017 Mar;37(3):1921 Authors: Kataoka J, Shiraha H, Horiguchi S, Sawahara H, Uchida D, Nagahara T, Iwamuro M, Morimoto H, Takeuchi Y, Kuwaki K, Onishi H, Nakamura S, Takaki A, Nouso K, Yagi T, Yamamoto K, Okada H Abstract Following the publication of this article, we realize that there were some errors in the manuscript. Details of the experiments describing the gene silencing of RUNX3 with small interfering RNA (siRNA) were erroneously included in thi...
Source: Oncology Reports - February 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research