Filtered By:
Cancer: Liver Cancer

This page shows you your search results in order of relevance. This is page number 16.

Order by Relevance | Date

Total 1432 results found since Jan 2013.

Abstract 5400: A novel combinatorial therapy for hepatocellular carcinoma (HCC)
The incidence of hepatocellular carcinoma (HCC) is rising in the US with parallel increase in mortality rate. Lack of effective therapy for advanced HCC mandates development of novel targeted therapies to counteract this fatal malady. Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and LYRIC, plays a pivotal role in hepatocarcinogenesis and serves as an ideal target for anti-HCC therapy. AEG-1 interacts with retinoid X receptor (RXR) and inhibits retinoic acid-induced gene expression and cell death. Retinoic acid has been evaluated for HCC treatment without promising result. Overexpression of AEG-1 might...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Srivastava, J., Rajasekaran, D., Siddiq, A., Gredler, R., Robertson, C. L., Akiel, M. A., Shen, X.-N., Ebeid, K. A. N., Salem, A. K., Fisher, P. B., Sarkar, D. Tags: Experimental and Molecular Therapeutics Source Type: research

CCL18/PITPNM3 enhances migration, invasion, and EMT through the NF-κB signaling pathway in hepatocellular carcinoma
Abstract Chemokine ligand 18 (CCL18) has been associated with hepatocellular carcinoma (HCC) metastasis. Here, we demonstrated a novel mechanism through which CCL18 enhances cell migration, invasion, and epithelial–mesenchymal transition (EMT) in HCC. (1) Using immunohistochemistry, we analyzed the expression of PITPNM3, a molecule that correlated with CCL18 signaling, in 149 HCC tissue specimens. The results showed that PITPNM3 expression is highly associated with tumor metastasis and differentiation; (2) in vitro experiments showed that CCL18 enhances cell migration, invasion, and EMT in PITPNM3(+) HCC cells b...
Source: Tumor Biology - October 8, 2015 Category: Cancer & Oncology Source Type: research

Blocking autophagy enhances meloxicam lethality to hepatocellular carcinoma by promotion of endoplasmic reticulum stress
ConclusionsOur results revealed that both ER stress and autophagy were involved in cell death evoked by meloxicam in HCC cells. This inhibition of autophagy to enhance meloxicam lethality, suggests a novel therapeutic strategy against HCC.
Source: Cell Proliferation - October 1, 2015 Category: Cytology Authors: Jingtao Zhong, Xiaofeng Dong, Peng Xiu, Fuhai Wang, Ju Liu, Honglong Wei, Zongzhen Xu, Feng Liu, Tao Li, Jie Li Tags: Original Article Source Type: research

Molecular subclasses of hepatocellular carcinoma predict sensitivity to fibroblast growth factor receptor inhibition
In conclusion, the S2 molecular subclass of HCC is sensitive to FGFR inhibition. FGFR4‐MAPK signaling plays an important role in driving proliferation of a molecular subclass of HCC. This classification system may help identify those patients who are most likely to benefit from inhibition of this pathway. This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - October 21, 2015 Category: Cancer & Oncology Authors: Benjamin Schmidt, Lan Wei, Danielle K. DePeralta, Yujin Hoshida, Poh Seng Tan, Xiaochen Sun, Janelle P. Sventek, Michael Lanuti, Kenneth K. Tanabe, Bryan C. Fuchs Tags: Cancer Therapy Source Type: research

Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor type, ranking as the third leading cause of all cancer-related deaths in the world. The post-surgical 5-year survival rate is low, largely due to the high recurrence rate. Therefore, the identification of target molecules that control the biological characteristics of HCC is of great importance. Ubiquitin-specific protease 22 (USP22) is a newly discovered deubiquitinating enzyme and is a cancer stem cell marker that plays a role in tumorigenesis, therapy resistance and cell cycle progression. Survivin is a member of the inhibi...
Source: International Journal of Oncology - October 20, 2015 Category: Cancer & Oncology Authors: Tang B, Liang X, Tang F, Zhang J, Zeng S, Jin S, Zhou L, Kudo Y, Qi G Tags: Int J Oncol Source Type: research

Overexpression of OCT4 contributes to progression of hepatocellular carcinoma
Abstract The abnormal change of octamer transcription factor 4 (OCT4) is associated with tumor progression; however, its effect on hepatocellular carcinoma (HCC) behavior remains unclear. The purpose of this study was to determine the correlation between HCC and OCT4. In the present study, IHC, western blot analysis, and QRT-PCR were performed to identify differentially expressed OCT4 in a series of HCC tissues and adjacent non-cancerous tissues. In addition, the functions of OCT4 on HCC progression were studied in vitro. Silencing of OCT4 with siRNA was performed in HCC cell lines, and the impact on proliferation...
Source: Tumor Biology - October 28, 2015 Category: Cancer & Oncology Source Type: research

TSG101 Silencing Suppresses Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death.
CONCLUSIONS TSG101 plays an important role in the development of HCC and may be a target for molecular therapy. PMID: 26537625 [PubMed - in process]
Source: Medical Science Monitor - November 8, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression.
In this study, we investigated whether BRD4 could be a target for treatment of human hepatocellular carcinoma (HCC). We show that BRD4 is over-expressed in HCC tissues. Suppression of BRD4, either by siRNA or using JQ1, a pharmaceutical BRD4 inhibitor, reduced cell growth and induced apoptosis in HCC cell lines while also slowing HCC xenograft tumor growth in mice. JQ1 treatment induced G1 cell cycle arrest by repressing MYC expression, which led to the up-regulation of CDKN1B (P27). JQ1 also de-repressed expression of the pro-apoptotic BCL2L11 (BIM). Moreover, siRNA knockdown of BIM attenuated JQ1-triggered apoptosis in H...
Source: Oncotarget - November 19, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells.
Abstract Evidences suggest that ERp57 and PGK-1 signaling lead to cancer cell proliferation and migration. We hypothesized that ERp57 and PGK-1 down-regulation may inactivate matrix metalloproteinase (MMP)-2, -9 expressions and inhibit hepatocellular carcinoma (HCC) migration. Antrodia cinnamomea is widely prescribed as an adjuvant to treat HCC in Taiwan. We aimed to investigate if ethanol extract of fruiting bodies of Antrodia cinnamomea (EEAC) and its active ingredients (i.e., zhankuic acid A, cordycepin, and adenosine) can modulate HCC cancer cells migration through ERp57 and PGK-1 and other molecular pathways ...
Source: The American Journal of Chinese Medicine - November 30, 2015 Category: Complementary Medicine Authors: Chen YY, Liu FC, Wu TS, Sheu MJ Tags: Am J Chin Med Source Type: research

TR4 nuclear receptor enhances the cisplatin chemo-sensitivity via altering the ATF3 expression to better suppress HCC cell growth.
Authors: Jiliang S, Hui L, Gonghui L, Renan J, Liang S, Mingming C, Chawnshang C, Xiujun C Abstract Early studies indicated that TR4 nuclear receptor (TR4) may play a key role to modulate the prostate cancer progression, its potential linkage to liver cancer progression, however, remains unclear. Here we found that higher TR4 expression in hepatocellular carcinoma (HCC) cells might enhance the efficacy of cisplatin chemotherapy to better suppress the HCC progression. Knocking down TR4 with TR4-siRNA in HCC Huh7 and Hep3B cells increased cisplatin chemotherapy resistance and overexpression of TR4 with TR4-cDNA in HC...
Source: Oncotarget - April 8, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The prognostic role and reduced expression of FOXJ2 in human hepatocellular carcinoma.
Authors: Zhang Z, Meng G, Wang L, Ma Y, Guan Z Abstract The current study aimed to investigate the potential role of the FOXJ2 (forkhead box J2) protein in the pathology of hepatocellular carcinoma (HCC). Western blotting was performed to determine the expression levels of FOXJ2 in HCC tissues and HCC cells. Specimens from 110 patients with HCC undergoing hepatic resection were evaluated for FOXJ2 expression using an immunohistochemical assay. The correlation between FOXJ2 expression and clinicopathological factors of the patients was determined by statistical analysis to determine the prognostic merit of FOXJ2 e...
Source: Molecular Medicine Reports - May 15, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Nuclear EpICD expression and its role in hepatocellular carcinoma.
This study was conducted to examine the nuclear expression of EpICD in hepatocellular carcinoma (HCC) and to assess the role of EpICD in HCC. EpICD immunoexpression was examined in 100 cases of HCC using tissue microarrays and correlated with clinicopathological parameters. We also examined the role of EpICD in HCC using EpICD cDNA transfected HCC cell line and EpCAM silenced HCC cell line by small interfering RNA (siRNA). Nuclear expression of EpICD was observed in 19 of 100 (19%) cases. Nuclear expression of EpICD significantly correlated with nuclear expression of β-catenin, and Ki-67 labeling index. In addition, nucl...
Source: Oncology Reports - May 15, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Bi-directional roles of IRF-1 on autophagy diminish its prognostic value as compared with Ki67 in liver transplantation for hepatocellular carcinoma.
Authors: Zhang HM, Li SP, Yu Y, Wang Z, He JD, Xu YJ, Zhang RX, Zhang JJ, Zhu ZJ, Shen ZY Abstract The prognostic values of IRF-1 and Ki-67 for liver transplantation (LT) of hepatocellular carcinoma (HCC) were investigated, as well as the mechanisms of IRF-1 in tumor suppression. Adult orthotropic liver transplantation cases (N = 127) were involved in the analysis. A significant decreased recurrence free survival (RFS) was found in the Ki-67 positive groups. Ki-67, tumor microemboli, the Milan and UCSF criteria were found to be independent risk factors for RFS. In LT for HCC beyond the Milan criteria, a significant...
Source: Oncotarget - May 20, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The role of monocarboxylate transpoter 1 to uptake acetate in low glycolytic hepatocellular carcinoma cell line HepG2 cells
Conclusions Our data demonstrate that acetate was supported to HCC cells through MCT1 specifically in the low glycolytic cancer cells, and high MCT1 expression is related with low glycolytic phenotype cancer that would be the therapeutic target or diagnosis probe for low glycolytic cancers.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Jeon, J., Lee, M., kim, j., Yun, M. Tags: MTA I: Basic Science Posters Source Type: research

Hepatoma‐derived growth factor promotes growth and metastasis of hepatocellular carcinoma cells
In conclusion, HDGF was overexpressed in HCC patients and cells, and HDGF might be closely correlated with HCC metastasis via regulating ERK signalling pathway. Copyright © 2016 John Wiley & Sons, Ltd.
Source: Cell Biochemistry and Function - June 6, 2016 Category: Biochemistry Authors: Guang‐yun Yang, Ai‐qun Zhang, Jing Wang, Chong‐hui Li, Xian‐qiang Wang, Ke Pan, Cheng Zhou, Jia‐hong Dong Tags: Research Article Source Type: research