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Therapy: Immunotherapy
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Total 29833 results found since Jan 2013.
Long non-coding RNAs in non-small cell lung cancer: Implications for preventing therapeutic resistance
Biochim Biophys Acta Rev Cancer. 2023 Sep 19:188982. doi: 10.1016/j.bbcan.2023.188982. Online ahead of print.ABSTRACTLung cancer has the highest mortality and morbidity rates among all cancers worldwide. Despite many complex treatment options, including radiotherapy, chemotherapy, targeted drugs, immunotherapy, and combinations of these treatments, efficacy is low in cases of resistance to therapy, metastasis, and advanced disease, contributing to low overall survival. There is a pressing need for the discovery of novel biomarkers and therapeutic targets for the early diagnosis of lung cancer and to determine the efficacy ...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Wenjuan Liu Bingli Zuo Wenting Liu Yanfei Huo Nasha Zhang Ming Yang Source Type: research
Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy
CONCLUSION: ABZ inhibits melanoma growth and metastasis. Moreover, ABZ synergized with PD-L1 blockade mediates tumor regression.PMID:37730912 | DOI:10.1007/s00432-023-05415-5
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Weinan Zhang Zhiqiang He Fucheng Liang Jie Gong Liuchang Tan Juan Yang Siji Song Luoyingzi Xie Yuangang Lu Source Type: research
Cardiovascular Imaging in Contemporary Cardio-Oncology: A Scientific Statement From the American Heart Association
Circulation. 2023 Sep 21. doi: 10.1161/CIR.0000000000001174. Online ahead of print.ABSTRACTAdvances in cancer therapeutics have led to dramatic improvements in survival, now inclusive of nearly 20 million patients and rising. However, cardiovascular toxicities associated with specific cancer therapeutics adversely affect the outcomes of patients with cancer. Advances in cardiovascular imaging have solidified the critical role for robust methods for detecting, monitoring, and prognosticating cardiac risk among patients with cancer. However, decentralized evaluations have led to a lack of consensus on the optimal uses of ima...
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Addison Tomas G Neilan Ana Barac Marielle Scherrer-Crosbie Tochi M Okwuosa Juan C Plana Kerryn W Reding Viviany R Taqueti Eric H Yang Vlad G Zaha American Heart Association Council on Cardiovascular Radiology and Intervention; Cardio-Oncology Commi Source Type: research
Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for NK-cell therapy in acute myeloid leukemia
In conclusion, the modification of the DNAM-1/CD112 axis in NK cells may be an effective novel immunotherapy for AML. Furthermore, these results suggest the potential of the expression levels of these molecules as prognostic markers in AML.PMID:37731380 | DOI:10.3324/haematol.2023.282915
Source: Haematologica - September 21, 2023 Category: Hematology Authors: Yuta Kaito Emi Sugimoto Fumi Nakamura Yutaka Tsukune Makoto Sasaki Shunsuke Yui Hiroki Yamaguchi Susumu Goyama Yasuhito Nannya Kinuko Mitani Hideto Tamura Yoichi Imai Source Type: research
A Novel Scoring Model of Deubiquitination Patterns Predicts Prognosis and Immunotherapeutic Response in Hepatocellular Carcinoma
In conclusion, our study revealed the crucial role of deubiquitination patterns in shaping TME complexity and diversity. A more personalized and effective antitumour immunotherapy strategy can be developed by utilizing the DUBscore model to identify deubiquitination patterns in individual HCC patients. Our findings also highlight that BRCC3 may serve as a potential therapeutic target in HCC and a predictive marker for immunotherapeutic response.PMID:37734237 | DOI:10.1016/j.tranon.2023.101789
Source: Translational Oncology - September 21, 2023 Category: Cancer & Oncology Authors: Jiahao Zhang Gefeng Wu Rui Peng Jun Cao Daoyuan Tu Jie Zhou Bingbing Su Shengjie Jin Guoqing Jiang Chi Zhang Dousheng Bai Source Type: research
Durable complete response to early immunotherapy discontinuation in a kidney transplant recipient with advanced cutaneous squamous cell carcinoma: A case report and review of literature
CONCLUSION: Organ transplant recipients with complete response to immunotherapy for cutaneous squamous cell carcinoma may continue to respond despite early treatment cessation. This may reduce the risks of late immune-related adverse events and acute graft rejection.PMID:37734447 | DOI:10.1016/j.trim.2023.101932
Source: Transplant Immunology - September 21, 2023 Category: Transplant Surgery Authors: Ziyao Lu Mohammed Afzal Keisuke Shirai Source Type: research
Cardiovascular Imaging in Contemporary Cardio-Oncology: A Scientific Statement From the American Heart Association
Circulation. 2023 Sep 21. doi: 10.1161/CIR.0000000000001174. Online ahead of print.ABSTRACTAdvances in cancer therapeutics have led to dramatic improvements in survival, now inclusive of nearly 20 million patients and rising. However, cardiovascular toxicities associated with specific cancer therapeutics adversely affect the outcomes of patients with cancer. Advances in cardiovascular imaging have solidified the critical role for robust methods for detecting, monitoring, and prognosticating cardiac risk among patients with cancer. However, decentralized evaluations have led to a lack of consensus on the optimal uses of ima...
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Daniel Addison Tomas G Neilan Ana Barac Marielle Scherrer-Crosbie Tochi M Okwuosa Juan C Plana Kerryn W Reding Viviany R Taqueti Eric H Yang Vlad G Zaha American Heart Association Council on Cardiovascular Radiology and Intervention; Cardio-Oncology Commi Source Type: research
Modeling the Development of Cellular Exhaustion and Tumor-Immune Stalemate
Bull Math Biol. 2023 Sep 21;85(11):106. doi: 10.1007/s11538-023-01207-7.ABSTRACTCellular exhaustion in various immune cells develops in response to prolonged stimulation and overactivation during chronic infections and in cancer. Marked by an upregulation of inhibitory receptors and diminished effector functions, exhausted immune cells are unable to fully eradicate the antigen responsible for the overexposure. In cancer settings, this results in a relatively small but constant tumor burden known as a localized tumor-immune stalemate. In recent years, studies have elucidated key aspects of the development and progression of...
Source: Bulletin of Mathematical Biology - September 21, 2023 Category: Bioinformatics Authors: Tyler Simmons Doron Levy Source Type: research
Alzheimer's disease: The role of T lymphocytes in neuroinflammation and neurodegeneration
Brain Res. 2023 Sep 19:148589. doi: 10.1016/j.brainres.2023.148589. Online ahead of print.ABSTRACTAlzheimer's disease, the leading cause of progressive cognitive decline globally, has been reported to be enhanced by neuroinflammation. Brain-resident innate immune cells and adaptive immune cells work together to produce neuroinflammation. Studies over the past decade have established the neuroimmune axis present in Alzheimer's disease; the crosstalk between adaptive and innate immune cells within and outside the brain is crucial to the onset and progression of Alzheimer's disease. Although the role of the adaptive immune sy...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Moses O Asamu Oladapo O Oladipo Oluseun A Abayomi Afeez A Adebayo Source Type: research
Research Progress in Immunotherapy of Gliomas
J Integr Neurosci. 2023 Aug 14;22(5):118. doi: 10.31083/j.jin2205118.ABSTRACTAlthough some progress has been made in tumor treatment, gliomas remain one of the tumors that can still seriously threaten human life and health. Due to the particularity of the immune microenvironment of the central nervous system and the strong invasiveness of tumors, the treatment of gliomas remains a major challenge. Currently, researchers have explored a large number of immunotherapy programs to improve the survival and prognosis of glioma patients, including tumor vaccines, immune checkpoint inhibitors, adoptive cell transfer therapy, viral...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Zhi-Hong Duan Zi-Long Wei Source Type: research
Emerging Challenges in Diagnosis and Treatment of Invasive Fungal Infections: Addressing the Impact of COVID-19 and New Pathogens
The objective of this study involved conducting a comprehensive literature search, followed by a rigorous selection process to identify relevant studies. Subsequently, a critical analysis of the literature was undertaken, and the obtained information was carefully synthesized to achieve the research aim.Recent FindingsRecent advances in diagnosis and treatment have greatly improved our ability to detect and manage of IFIs. The non-culture-based techniques have increased the accuracy and speed of fungal detection, while new antifungal drugs and immunotherapies have shown promising results in the treatment of IFIs. The princ...
Source: Current Fungal Infection Reports - September 21, 2023 Category: Infectious Diseases Source Type: research
Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
Ferroptosis and WDFY4 as novel targets for immunotherapy of lung adenocarcinoma
CONCLUSIONS: The results indicate that promoting infiltration and activation of B cell populations could improve the long-term survival of LUAD patients, thereby offering a potential novel immunotherapeutic approach for LUAD. Besides, the promotion of cancer cell ferroptosis and upregulation of WDFY4 expression have been shown to induce the infiltration and activation of B cell populations. Furthermore, the overexpression of WDFY4 can significantly inhibit the growth of lung adenocarcinoma in vitro and in vivo, highlighting its potential as a target for immunotherapy in LUAD.PMID:37728413 | DOI:10.18632/aging.205042
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Ling Huang Lifan Zhong Ruxin Cheng Limei Chang Mingyan Qin Huaping Liang Zhongkai Liao Source Type: research
Characterization of tumor microenvironment and sensitive chemotherapy drugs based on cuproptosis-related signatures in renal cell carcinoma
Aging (Albany NY). 2023 Sep 19;15. doi: 10.18632/aging.205043. Online ahead of print.ABSTRACTCuproptosis is a novel type of copper-induced cell death and is considered as a new therapeutic target for many cancers. Distant metastases occur in about 40% of patients with advanced renal cell carcinoma (RCC), with a poor 5-year prognosis of about 10%. Through a series of comprehensive analyses, four differentially expressed cuproptosis-related lncRNAs (DECRLs) were identified as candidate biomarkers for RCC. The risk model constructed by using these four DECRLs can better predict the prognosis of patients with RCC, which is det...
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Jiefu Tang Fan Yao Zhiyong Yao Xiao-Liang Xing Source Type: research
A Novel pyroptosis-related signature for predicting prognosis and evaluating tumor immune microenvironment in ovarian cancer
J Ovarian Res. 2023 Sep 20;16(1):196. doi: 10.1186/s13048-023-01275-2.ABSTRACTOvarian cancer (OV) is the most fatal gynecological malignant tumor worldwide, with high recurrence rates and great heterogeneity. Pyroptosis is a newly-acknowledged inflammatory form of cell death with an essential role in cancer progression, though studies focusing on prognostic patterns of pyroptosis in OV are still lacking. Our research filtered 106 potential pyroptosis-related genes (PRGs) among the 6406 differentially expressed genes (DEGs) between the 376 TCGA-OV samples and 180 normal controls. Through the LASSO-Cox analysis, the 6-gene p...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Jiani Yang Chao Wang Yue Zhang Shanshan Cheng Yanna Xu Yu Wang Source Type: research
