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Therapy: Immunotherapy
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Total 29833 results found since Jan 2013.
Imaging immune checkpoint networks in cancer tissues with supermultiplexed SERS nanoprobes
Biomaterials. 2023 Sep 12;302:122327. doi: 10.1016/j.biomaterials.2023.122327. Online ahead of print.ABSTRACTCombined immune checkpoint (ICP) inhibitors maximize immune response rates of patients compared to the single-drug treatment strategy in cancer immunotherapy, and prediction of such optimal combinations requires high-throughput imaging techniques and suitable data analysis. In this work, we report a rational strategy for predicting combined drugs of ICP inhibitors based on supermultiplexed surface-enhanced Raman scattering (SERS) imaging and correlation network analysis. To this end, we first built an ultrasensitive...
Source: Biomaterials - September 16, 2023 Category: Materials Science Authors: Jin Li Fugang Liu Xinyuan Bi Jian Ye Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
CONCLUSIONS: We have developed a GPCR-TME classifier that could predict the OS and immunotherapy response of patients with melanoma highly effectively based on multi-omics analysis.PMID:37716991 | PMC:PMC10504724 | DOI:10.1186/s40001-023-01346-6
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Kangjie Shen Qiangcheng Wang Lu Wang Yang Yang Min Ren Yanlin Li Zixu Gao Shaoluan Zheng Yiteng Ding Jiani Ji Chenlu Wei Tianyi Zhang Yu Zhu Jia Feng Feng Qin Yanwen Yang Chuanyuan Wei Jianying Gu Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
Selecting Triple Negative Breast Cancer Patients for Immunotherapy
Surg Oncol Clin N Am. 2023 Oct;32(4):733-745. doi: 10.1016/j.soc.2023.05.005. Epub 2023 Jun 5.ABSTRACTThe approval of preoperative immunotherapy combined with chemotherapy is a practice-changing advance for patients with early-stage triple-negative breast cancer. The optimal patient selection requires careful attention to staging and balancing potential risks with expected benefits, particularly as it relates to immune-related adverse events.PMID:37714640 | DOI:10.1016/j.soc.2023.05.005
Source: Clinical Breast Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Stephanie Downs-Canner Elizabeth A Mittendorf Source Type: research
Machine learning- and WGCNA-mediated double analysis based on genes associated with disulfidptosis, cuproptosis and ferroptosis for the construction and validation of the prognostic model for breast cancer
CONCLUSION: Multiplex analysis based on DRGs, CRGs and FRGs correlated strongly with BC, providing new insights for developing clinical prognostic tools and designing immunotherapy regimens for BC patients.PMID:37712959 | DOI:10.1007/s00432-023-05378-7
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Lijun Xu Shanshan Wang Dan Zhang Yunxi Wu Jiali Shan Huixia Zhu Chongyu Wang Qingqing Wang Source Type: research
Stereotactic Radiosurgery Results in Non-Small-Cell Lung Cancer Patients with Brain Metastases in the Era of Modern Systemic Treatment Agents
CONCLUSION: Using current systemic agents with radiotherapy for brain metastasis significantly affected post-radiotherapy intracranial progression-free survival.PMID:37712866 | DOI:10.5152/ThoracResPract.2023.23025
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Feyza Ya şar Daşgın Tar ı Kargıoğlu Aliye Arslan Ali Kerim Aksakal Binnur Dadak Fatma Bet ül Ayrak Ezgi G ökçe İpek Pinar Aral Gonca Alt ınışık İnan Y ılmaz Tezcan Source Type: research
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
Machine learning- and WGCNA-mediated double analysis based on genes associated with disulfidptosis, cuproptosis and ferroptosis for the construction and validation of the prognostic model for breast cancer
CONCLUSION: Multiplex analysis based on DRGs, CRGs and FRGs correlated strongly with BC, providing new insights for developing clinical prognostic tools and designing immunotherapy regimens for BC patients.PMID:37712959 | DOI:10.1007/s00432-023-05378-7
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lijun Xu Shanshan Wang Dan Zhang Yunxi Wu Jiali Shan Huixia Zhu Chongyu Wang Qingqing Wang Source Type: research
Immunotherapy for the elderly. Maybe the best option for lung cancer?
Cancer Treat Res Commun. 2023 Sep 12:100762. doi: 10.1016/j.ctarc.2023.100762. Online ahead of print.ABSTRACTLung cancer is usually diagnosed at advanced stage and systematic therapy is administered. New current diagnostic techniques such as the convex-endobronchial ultrasound, radial endobronchial ultrasound, cone beam ct, electromagnetic navigation and robotic bronchoscopy provide us with a high diagnostic yield. These techniques are minimal invasive and patients with comorbidities such as chronic obstructive pulmonary disease and heart failure can be diagnosed with minimal adverse effects. All these techniques provide s...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Paul Zarogoulidis Dimitris Matthaios Panagoula Oikonomou Christina Nikolaou Charalampos Charalampidis Chrysanthi Sardeli Source Type: research
Enhancing personalized immune checkpoint therapy by immune archetyping and pharmacological targeting
We describe the potential of strategies that score the mutual spatiotemporal modulation between T-cells and other cellular components of the TME. Additionally, we will provide an overview of a range of synthetic and naturally occurring or derived small molecules. We will compare compounds that were recently identified by in silico prediction to wet lab-validated drug candidates with the potential to function as ICIs and/or modulators of the cellular components of the TME.PMID:37714393 | DOI:10.1016/j.phrs.2023.106914
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Claudia Cerella Mario Dicato Marc Diederich Source Type: research
Molecular subtypes and prognostic models for predicting prognosis of lung adenocarcinoma based on miRNA-related genes
CONCLUSION: Such miRNA-associated target gene characterization could be useful for prognostic prediction and contribute to therapeutic decision-making in LUAD.PMID:37711127 | DOI:10.2174/0929867331666230914151943
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Yuxi Wei Wei Zhong Yalan Bi Xiaoyan Liu Qing Zhou Jia Liu Mengzhao Wang Hong Zhang Minjiang Chen Source Type: research
