Enhancing personalized immune checkpoint therapy by immune archetyping and pharmacological targeting

We describe the potential of strategies that score the mutual spatiotemporal modulation between T-cells and other cellular components of the TME. Additionally, we will provide an overview of a range of synthetic and naturally occurring or derived small molecules. We will compare compounds that were recently identified by in silico prediction to wet lab-validated drug candidates with the potential to function as ICIs and/or modulators of the cellular components of the TME.PMID:37714393 | DOI:10.1016/j.phrs.2023.106914
Source: Cell Research - Category: Cytology Authors: Source Type: research