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Vaccination: Varicella-Zoster Virus Vaccine

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Total 265 results found since Jan 2013.

The Case of the Painful Blisters
BY ​JOHN DAVIS, MD; & ​RYAN THOMPSON, MD​​An 89-year-old woman presented to the emergency department with three days of painful swallowing and oral blisters. She first noticed intraoral blisters two days before presentation, with blisters on the upper lip occurring the following day. She was only able to swallow small amounts of liquids.​ Intraoral lesions on left half of the hard and soft palates without extension across the midline.Her exam revealed multiple vesicular lesions on the left upper lip and nares and multiple vesicular lesions extending from the midline of the hard and soft palates late...
Source: The Case Files - June 28, 2016 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Fight Aging! Newsletter, May 16th 2016
In this study the authors demonstrate that, as in many other cases, the methodology of delivery matters just as much as the details of the cells used: Retinal and macular degenerative diseases affect millions of people worldwide. Similar to other neurodegenerative diseases, there are no effective treatments that can stop retinal degeneration or restore degenerative retina. Recent advances in stem cell technology led to development of novel cell-based therapies, some are already in phase I/II clinical trials. Studies from our group and others suggest that human bone marrow-derived mesenchymal stem cells (hBM-MSC) m...
Source: Fight Aging! - May 15, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Better effectiveness of herpes zoster vaccine in preventing herpes zoster ophthalmicus with ocular involvement
Herpes zoster ophthalmicus (HZO) occurs when the varicella-zoster virus is reactivated in the ophthalmic division of the trigeminal nerve, either with or without ocular involvement. Serious sequelae, including chronic ocular inflammation, vision loss, and disabling pain can occur in patients with ocular involvement. Our previous study reported that herpes zoster (HZ) vaccine was effective in protecting against HZO with ocular involvement. The aim was to confirm this observation by taking advantage of a novel natural language processing (NLP) algorithm to identify HZO patients with ocular involvement avoiding time-consuming chart review
Source: Value in Health - April 30, 2016 Category: Global & Universal Authors: H.F. Tseng, C. Zheng, Y. Luo, L.S. Sy, C. Mercado, S.J. Jacobsen Source Type: research

Herpes Zoster
Herpes zoster causes significant suffering owing to acute and chronic pain or postherpetic neuralgia (PHN). Varicella-zoster virus –induced neuronal destruction and inflammation causes the principal problems of pain, interference with activities of daily living, and reduced quality of life in older adults. The optimal treatment of herpes zoster requires early antiviral therapy and careful pain management. For patients who hav e PHN, evidence-based pharmacotherapy using topical lidocaine patch, gabapentin, pregabalin, tricyclic antidepressants, or opiates can reduce pain burden. The live attenuated zoster vaccine is effec...
Source: Clinics in Geriatric Medicine - April 8, 2016 Category: Geriatrics Authors: Kenneth Schmader Source Type: research

Featured Review: Vaccines for preventing herpes zoster in older adults
Vaccine helps prevent shingles in older adults for up to three years The varicella zoster virus causes chickenpox and can remain dormant inside nerve cells. After many years, it can reactivate and travel through the nerve to the skin, causing itching, numbness, tingling or local pain, and then blisters along the nerve path. These blisters are often accompanied with inflammation of the nerves and severe pain, which can affect quality of life. This is called herpes zoster or shingles. It affects people with low immunity such as older people. There are about 5.22 episodes of shingles for every 1000 older people. This is ...
Source: Cochrane News and Events - March 21, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news

Herpes zoster ophthalmicus: declining age at presentation
Conclusions Ever since the introduction of varicella vaccination in children, there has been debate regarding its effect on zoster epidemiology, particularly regarding the potential to reduce population exposure and limit repeated immunological boosts against varicella zoster virus in adults. Patients presenting to MEEI with HZO were younger on average in 2013 than in 2007. Although a population-based study is necessary to test the hypothesis, our study suggests that varicella vaccination of children remains a possible explanation for the increased number of cases and reduction in mean age of newly diagnosed patients.
Source: British Journal of Ophthalmology - February 23, 2016 Category: Opthalmology Authors: Davies, E. C., Pavan-Langston, D., Chodosh, J. Tags: Eye (globe), Neurology, Epidemiology Original articles - Clinical science Source Type: research

Don’t shrug off shingles
If you had chickenpox as a kid, there is a good chance you may develop shingles later in life. “In fact, one in three is predicted to get shingles during their lifetime,” says Dr. Anne Louise Oaklander, director of the Nerve Unit at Harvard-affiliated Massachusetts General Hospital. The same varicella-zoster virus that causes chickenpox also causes shingles. After the telltale spots of chickenpox vanish, the virus lies dormant in your nerve cells near the spinal cord and brain. When your immunity weakens from normal aging or from illnesses or medications, the virus can re-emerge. It then travels along a nerve to trigge...
Source: New Harvard Health Information - February 18, 2016 Category: Consumer Health News Authors: Matthew Solan Tags: Healthy Aging Infectious diseases Vaccines Source Type: news

Herpes Zoster and Post-herpetic Neuralgia
Abstract Herpes zoster (HZ), which is commonly referred to as shingles, is a syndrome of pain and skin rash that is caused by reactivation of varicella zoster virus (VZV). After primary varicella infection (chicken pox), the virus goes into latency in the spinal cord ganglia. The virus is reactivated when immunity to VZV declines as happens with aging or immunosuppression. The risk of zoster increases steeply after the age of 50 years. Post-herpetic neuralgia (PHN), defined as pain persisting more than 3 months after the skin rash has healed, is a serious consequence of HZ that is difficult to treat and signific...
Source: Current Geriatrics Reports - January 28, 2016 Category: Geriatrics Source Type: research

Developments in Varicella Zoster Virus Vasculopathy
Abstract Varicella zoster virus (VZV) is a highly neurotropic human herpesvirus. Primary infection usually causes varicella (chicken pox), after which virus becomes latent in ganglionic neurons along the entire neuraxis. VZV reactivation results in zoster (shingles) which is frequently complicated by chronic pain (postherpetic neuralgia). VZV reactivation also causes meningoencephalitis, myelitis, ocular disorders, and vasculopathy, all of which can occur in the absence of rash. This review focuses on the association of VZV and stroke, and on the widening spectrum of disorders produced by VZV vasculopathy in immu...
Source: Current Neurology and Neuroscience Reports - January 11, 2016 Category: Neuroscience Source Type: research

Herpes Zoster and Postherpetic Neuralgia: Practical Consideration for Prevention and Treatment.
Authors: Jeon YH Abstract Herpes zoster (HZ) is a transient disease caused by the reactivation of latent varicella zoster virus (VZV) in spinal or cranial sensory ganglia. It is characterized by a painful rash in the affected dermatome. Postherpetic neuralgia (PHN) is the most troublesome side effect associated with HZ. However, PHN is often resistant to current analgesic treatments such as antidepressants, anticonvulsants, opioids, and topical agents including lidocaine patches and capsaicin cream and can persist for several years. The risk factors for reactivation of HZ include advanced age and compromised cell-m...
Source: Korean Journal of Pain - December 1, 2015 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Cost-Effectiveness Analysis of Herpes Zoster Vaccination In Hong Kong
Herpes zoster (HZ), caused by reactivation of varicella zoster virus, is characterized by dermatome-based rash and severe pain. Post-herpetic neuralgia may occur following HZ. The risk of HZ increases with older age and reduced immunity. HZ vaccine has been first approved for adults aged 60 years and above, and recently approved for 50 years and above. The aim of present study was to evaluate the cost-effectiveness of implementing HZ vaccination program for adults at age 50 years versus 60 years in Hong Kong from the perspective of society.
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: C Lee, J You Source Type: research

Functional decline and herpes zoster in older people: an interplay of multiple factors.
Abstract Herpes zoster is a frequent painful infectious disease whose incidence and severity increase with age. In older people, there is a strong bidirectional link between herpes zoster and functional decline, which refers to a decrement in ability to perform activities of daily living due to ageing and disabilities. However, the exact nature of such link remains poorly established. Based on the opinion from a multidisciplinary group of experts, we here propose a new model to account for the interplay between infection, somatic/psychiatric comorbidity, coping skills, polypharmacy, and age, which may account for ...
Source: Aging Clinical and Experimental Research - October 6, 2015 Category: Geriatrics Authors: Herpes Zoster and Functional Decline Consortium Tags: Aging Clin Exp Res Source Type: research

Zoster Vaccine and the Risk of Postherpetic Neuralgia in Patients Who Developed Herpes Zoster Despite Having Received the Zoster Vaccine
Conclusions. Among persons experiencing HZ, prior HZ vaccination is associated with a lower risk of PHN in women but not in men. This sex-related difference may reflect differences in healthcare-seeking patterns and deserve further investigation.
Source: The Journal of Infectious Diseases - September 21, 2015 Category: Infectious Diseases Authors: Tseng, H. F., Lewin, B., Hales, C. M., Sy, L. S., Harpaz, R., Bialek, S., Luo, Y., Jacobsen, S. J., Reddy, K., Huang, P.-y., Zhang, J., Anand, S., Bauer, E. M., Chang, J., Tartof, S. Y. Tags: VIRUSES Source Type: research