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Vaccination: Varicella-Zoster Virus Vaccine

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How Long Does Shingles Last In The Elderly?
View Original Article Here: How Long Does Shingles Last In The Elderly? Shingles is a viral infection that follows a varicella-zoster infection, although it can take decades for symptoms of the secondary disease to emerge. The condition presents as a painful and blistering rash, but it is not life-threatening. According to the Center for Disease Control, there are nearly one million cases in the United States each year, and almost half of those cases are in older adults over age 60. Some people only see one instance of the illness, while others have recurring symptoms, but 30 percent of Americans will develop shingles at s...
Source: Shield My Senior - December 8, 2017 Category: Geriatrics Authors: Vin Tags: Senior Safety Source Type: blogs

Herpes Zoster in the Older Adult
Publication date: December 2017 Source:Infectious Disease Clinics of North America, Volume 31, Issue 4 Author(s): Amrita R. John, David H. CanadayTeaser Herpes zoster (HZ) is the result of reactivation of latent varicella zoster virus (VZV) and occurs most frequently in older adults. Classically, HZ presents as a unilateral, selflimited, dermatomal rash. Postherpetic neuralgia (PHN) is a common sequela, presenting as severe pain that persists after the rash has resolved. In the elderly, PHN can be debilitating and requires a prompt diagnosis, treatment with antivirals, and adequate pain control. A longer-term pain managem...
Source: Infectious Disease Clinics of North America - November 20, 2017 Category: Infectious Diseases Source Type: research

Family history of zoster and risk of developing herpes zoster
Herpes zoster (HZ), or shingles, is a painful vesicular rash, usually unilateral, caused by the varicella zoster virus (VZV). The pain and potential long-term effects associated with HZ, including post-herpetic neuralgia (PHN) and cranial nerve damage, can be debilitating, with a serious impact on quality of life. In 2006, the zoster vaccine received Food and Drug Administration (FDA) approval for use in healthy adults aged 60 and older. Zoster vaccine can increase cell-mediated immunity to VZV and reduce the risk of HZ (Tseng et al., 2011; Oxman et al., 2005).
Source: International Journal of Infectious Diseases - November 13, 2017 Category: Infectious Diseases Authors: Hung Fu Tseng, Margaret Chi, Peggy Hung, Rafael Harpaz, D. Scott Schmid, Philip LaRussa, Lina S. Sy, Yi Luo, Kimberly Holmquist, Harpreet Takhar, Steven J. Jacobsen Source Type: research

FDA Approves New Shingles Vaccine That Is More Than 90% Effective
BOSTON (CBS) – There’s a new shingles vaccine in town. Shingrix was approved by the FDA last week, and a CDC advisory panel just voted to recommend it for patients 50 and older. It is given as two injections two to six months apart, and in studies the vaccine was found to be more than 90% effective. Shingrix is not the only shingles vaccine available. Zostavax has been around for more than a decade, but it may not be as effective as this new vaccine, especially in older patients. Vaccine experts are not only recommending the new vaccine for people who have never been vaccinated but say that people who got the old ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 26, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Syndicated Local Dr. Mallika Marshall Shingles Source Type: news

An Infection that Vaccine Doesn't Prevent over Time
​BY NATALIE CAZEAU, ​MSC; ERICA ROMAN HERNANDEZ; KINZA IJAZ; AMY SCHEUERMANN; AHMED RAZIUDDIN, MDA 43-year-old man presented to the ED with a rash in a C7 dermatomal pattern that was burning and painful. The patient said the rash began three weeks before the ED visit as a group of little blisters on his right upper back and extending down his right arm. The patient was worried and in mild distress as the rash continued to burn, and he reported numbness to the area. He mentioned he had received the shingles vaccine in the past.​The patient's rash was yellow, crusty, and tender upon palpation. The area was hyperke...
Source: The Case Files - October 25, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Herpes Zoster in the Older Adult
Herpes zoster (HZ) is the result of reactivation of latent varicella zoster virus (VZV) and occurs most frequently in older adults. Classically, HZ presents as a unilateral, selflimited, dermatomal rash. Postherpetic neuralgia (PHN) is a common sequela, presenting as severe pain that persists after the rash has resolved. In the elderly, PHN can be debilitating and requires a prompt diagnosis, treatment with antivirals, and adequate pain control. A longer-term pain management strategy is required if PHN occurs. A modestly effective vaccine exists and is recommended for older individuals.
Source: Infectious Diseases Clinics of North America - October 25, 2017 Category: Infectious Diseases Authors: Amrita R. John, David H. Canaday Source Type: research

Post-herpetic neuralgia - a review of current management and future directions.
Authors: Schutzer-Weissmann J, Farquhar-Smith P Abstract INTRODUCTION: Post-herpetic neuralgia (PHN) is common and treatment is often suboptimal with less than half of patients achieving adequate 50% pain relief. As an area of unmet clinical need and as an archetype of neuropathic pain, it deserves the attention of clinicians and researchers. Areas covered: This review summarises the epidemiology, pathophysiology, risk factors and clinical features of varicella infection. It describes the current and possible future management strategies for preventing varicella infection and reactivation and for treating PHN. Expe...
Source: Expert Opinion on Pharmacotherapy - October 15, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Baby Foreskin Is Being Used To Make Vaccines
Conclusion Vaccine companies have regularly used blood and body parts from killed cows, dogs, worms, mice, chickens, human babies, monkeys, guinea pigs, rabbits, hamsters, rats, etc., to make these vaccines, so using foreskin from newborn babies may not surprise some. For many, it is appalling. [28] Circumcisions fuel multi-billion dollar industries. If you see neonatal foreskin for sale, which is very easy to find on the internet, remember that these newborn children didn’t consent to being circumcised and they didn’t consent for their foreskin to be sold, used for research purposes, or to be injected into the people ...
Source: vactruth.com - September 28, 2017 Category: Allergy & Immunology Authors: Augustina Ursino Tags: Augustina Ursino Top Stories circumcision truth about vaccines Source Type: blogs

I Got Shingles As A Healthy 34-Year-Old, And It Was The Worst Pain I've Ever Felt
By Amanda MacMillan A few weeks after my 34th birthday, my husband and I went for a Saturday hike — a weekly ritual we’d started after moving to New York State’s Catskill Mountains region a few months earlier. I’d been feeling a bit under the weather, and I hoped the fresh autumn air would do me good. It didn’t. Later that night, I had chills and my skin felt strangely sensitive, like when you’re coming down with the flu. On top of that, it felt like I had pulled a muscle in my back or chest; when I breathed or stretched certain ways, I’d get shooting pains across my body. I blamed...
Source: Healthy Living - The Huffington Post - May 4, 2017 Category: Consumer Health News Source Type: news

Immunogenicity and safety of an adjuvanted herpes zoster subunit candidate vaccine in adults ≥50 years of age with a prior history of herpes zoster: a phase III, non-randomized, open-label clinical trial.
Abstract This phase III, non-randomized, open-label, multi-center study (NCT01827839) evaluated the immunogenicity and safety of an adjuvanted recombinant subunit herpes zoster (HZ) vaccine (HZ/su) in adults aged ≥50 years with prior physician-documented history of HZ. Participants (stratified by age: 50-59, 60-69 and ≥70 years) received 2 doses of HZ/su 2 months apart and were followed-up for another 12 months. Anti-glycoprotein E (gE) antibodies were measured by enzyme-linked immunosorbent assay before vaccination and 1 month after the second dose (Month 3). Solicited local and general adverse events (A...
Source: Pain Physician - January 8, 2017 Category: Anesthesiology Authors: Godeaux O, Kovac M, Shu D, Grupping K, Campora L, Douha M, Heineman TC, Lal H Tags: Hum Vaccin Immunother Source Type: research

The Dangerous Expansion of Adult Vaccinations
Conclusion The vaccination comprises a misguided and unsafe national health care program which claims to prevent disease. Many significant health injuries are associated with vaccinating adults. Government resources are being spent researching and developing new and different vaccinations. Subjecting adults to more vaccinations is likely to cause more health injury and illness. References: http://www.vaccinationcouncil.org/2012/07/05/herd-immunity… http://www.cdc.gov/chronicdisease/overview/ http://www.vaccinationcouncil.org/2011/02/18/60-lab-studies… http://www.cdc.gov/vaccines/schedules/hcp/adult.html http:...
Source: vactruth.com - September 10, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Recent Articles Top Stories adult vaccination adult vaccines new vaccines shingles vaccine truth about vaccines Source Type: blogs

Quantification of risk factors for postherpetic neuralgia in herpes zoster patients: A cohort study
Conclusions: Postherpetic neuralgia risk was increased for a number of patient characteristics and comorbidities, notably with age and among those with severe immunosuppression. As zoster vaccination is contraindicated for patients with severe immunosuppression, strategies to prevent zoster in these patients, which could include the new subunit zoster vaccine, are an increasing priority.
Source: Neurology - July 3, 2016 Category: Neurology Authors: Forbes, H. J., Bhaskaran, K., Thomas, S. L., Smeeth, L., Clayton, T., Mansfield, K., Minassian, C., Langan, S. M. Tags: Viral infections, Neuropathic pain, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research